Polycyclic Aromatic Hydrocarbons–Associated MicroRNAs and Heart Rate Variability in Coke Oven Workers

Huang, Suli; Deng, Qifei; Feng, Jing; Zhang, Xiaomin; Dai, Xiayun; Li, Lü; Yang, Binyao; Wu, Tangchun; Cheng, Jinquan

doi:10.1097/jom.0000000000000564

Cited by 22 publications

(8 citation statements)

References 43 publications

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“…We propose miR-142-5p, miR-655-5p, and miR-196a-1-5p as miRNAs with a high and stable expression in plasma exosome, stool, and urine respectively, while piR-43137, chr6.tRNA59-IleAAT, and piR-33543 as the candidate references among other sncRNAs in plasma exosomes, stool, and urine respectively. miR-142-5p has been found dysregulated in plasma but not in exosomes [ 47 – 49 ] although it has been demonstrated that in rats the activation of the acute stress response modifies its profile in plasma exosomes [ 50 ]. miR-655-5p and miR-196a-1-5p have never been studied in stool and urine, except for miR-196a reported to be altered in focal segmental glomerulosclerosis [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Small non-coding RNA profiling in human biofluids and surrogate tissues from healthy individuals: description of the diverse and most represented species

et al. 2017

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The role of non-coding RNAs in different biological processes and diseases is continuously expanding. Next-generation sequencing together with the parallel improvement of bioinformatics analyses allows the accurate detection and quantification of an increasing number of RNA species. With the aim of exploring new potential biomarkers for disease classification, a clear overview of the expression levels of common/unique small RNA species among different biospecimens is necessary. However, except for miRNAs in plasma, there are no substantial indications about the pattern of expression of various small RNAs in multiple specimens among healthy humans.By analysing small RNA-sequencing data from 243 samples, we have identified and compared the most abundantly and uniformly expressed miRNAs and non-miRNA species of comparable size with the library preparation in four different specimens (plasma exosomes, stool, urine, and cervical scrapes).Eleven miRNAs were commonly detected among all different specimens while 231 miRNAs were globally unique across them. Classification analysis using these miRNAs provided an accuracy of 99.6% to recognize the sample types. piRNAs and tRNAs were the most represented non-miRNA small RNAs detected in all specimen types that were analysed, particularly in urine samples. With the present data, the most uniformly expressed small RNAs in each sample type were also identified. A signature of small RNAs for each specimen could represent a reference gene set in validation studies by RT-qPCR.Overall, the data reported hereby provide an insight of the constitution of the human miRNome and of other small non-coding RNAs in various specimens of healthy individuals.

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Section: Discussionmentioning

confidence: 99%

Small non-coding RNA profiling in human biofluids and surrogate tissues from healthy individuals: description of the diverse and most represented species

et al. 2017

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“…miR-145is highly expressed in vascular smooth muscle cells (VSMC) and it controls the differentiation of VSMC into a functional phenotype, thus protecting against lesion formation (Rangrez et al, 2011;Wei et al, 2013). To date, few investigations have evaluated miRNAs expression profiles in populations exposed to PAHs (Deng et al, 2014a(Deng et al, , 2014bHuang et al, 2016;Woeller et al, 2016). The data found in this research have demonstrated a significant increase in the plasmatic expression levels of miR-126, and miR-155 in women highly exposed to PAHs (T2 and T3) compared to miRNAs expression levels in women with low exposure to PAHs (T1) (Figs.…”

Section: Plasma Mirnas Expression Levelsmentioning

confidence: 99%

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been considered a risk determinant for the development of cardiovascular diseases (CVD). Therefore, the aim of this study was to assess expression levels of vascular‐related miRNAs, miR‐126, miR‐155, and miR‐145, in plasma from women (aged 19–81 years) exposed (n = 100) and non‐exposed (n = 20) to PAHs via biomass combustion smoke.1‐hydroxypyrene (1‐OHP) was determined in urine as a biomarker of exposure to PAHs using high‐resolution liquid chromatography. Plasma expression levels of proposed miRNAs were determined by quantitative real‐time PCR. Additionally, traditional risk factors (age, blood pressure, serum lipid profile, blood glucose, and among others) associated with CVD were evaluated. Urinary 1‐OHP concentrations and plasma expression levels of miR‐126 and miR‐155 were significantly higher (P < 0.05) in women using wood as a fuel source in their homes (indoor) compared to women from the reference group (non‐exposed to biomass smoke). Besides, multivariate linear regression analyses revealed that miR‐126[β = 0.61; 95% confidence interval (0.32–0.90)] and miR‐155 [β = 0.45; 95% confidence interval (0.13–0.84)] expression levels were significantly associated with urinary 1‐OHP concentrations after being adjusted by traditional risk factors (P < 0.05). In contrast, no significant relationship was found between miR‐145 and urinary 1‐OHP levels. Furthermore, miRNAs assessed in this investigation are associated with CVD events. Consequently, actions to reduce exposure to PAHs in the evaluated population are warranted. Environ. Mol. Mutagen. 60:546–558, 2019. © 2019 Wiley Periodicals, Inc.

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“…The studies included in this review showed evidence that exposure to PAH was associated with the presence of cardiovascular diseases and aggravations, such as increased blood pressure levels (22) , heart rate variation (14,(24)(25)(26) and ischemic heart disease (17,20,27) ; and respiratory diseases such as reduced lung function (23) , chronic obstructive pulmonary disease (COPD) (18)(19)28) , asthma (19) , and symptoms such as wheezing (16) , cough (16,18) , lung wheezing (19), tight chest (19) , shortness of breath on exertion (19) and sore throat (16) .…”

Section: Discussionmentioning

confidence: 99%

“…Polycyclic aromatic hydrocarbons -associated microRNAs and heart rate variability in coke oven workers (26) .…”

Section: China Web Of Sciencementioning

confidence: 99%

Polycyclic aromatic hydrocarbons and development of respiratory and cardiovascular diseases in workers

et al. 2020

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Objectives: to identify the scientific evidence on the development of cardiovascular and respiratory diseases due to workplace contamination by polycyclic aromatic hydrocarbons. Methods: integrative literature review. The search for primary articles was held in October 2017 in the Medical Literature Analysis and Retrieval System Online (through Pubmed), Web of Science and Latin American and Caribbean Literature in Health Sciences (LILACS). Results: the 16 studies analyzed showed that exposure to polycyclic aromatic hydrocarbons was associated with cardiovascular diseases, such as increased blood pressure, heart rate variation, and ischemic heart disease; and respiratory disorders, such as decreased lung function, chronic obstructive pulmonary disease, asthma, wheeze, coughing, pulmonary wheezing, chest tightness, effort dyspnea, and sore throat. Conclusions: polycyclic aromatic hydrocarbons cause deleterious effects on the cardiovascular and respiratory systems through mutations and cellular inflammation, being a risk to exposed individuals.

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Polycyclic Aromatic Hydrocarbons–Associated MicroRNAs and Heart Rate Variability in Coke Oven Workers

Abstract: Plasma miRNAs might act as potential biomarkers for the adverse effect of PAH exposure on the cardiovascular system.

Cited by 22 publications

References 43 publications

Small non-coding RNA profiling in human biofluids and surrogate tissues from healthy individuals: description of the diverse and most represented species

Small non-coding RNA profiling in human biofluids and surrogate tissues from healthy individuals: description of the diverse and most represented species

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Polycyclic aromatic hydrocarbons and development of respiratory and cardiovascular diseases in workers

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