Polycyclic aromatic hydrocarbons in marine mammals: A review and synthesis

Lourenço, Rafael André; Taniguchi, Satie; Silva, Josilene da; Gallotta, Fabiana D.C.; Bı́cego, Márcia Caruso

doi:10.1016/j.marpolbul.2021.112699

Cited by 20 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The hepatic BPP concentration was significantly higher than those in the blubber and kidney. 37 Its concentration was the lowest among the six compounds, implying that the current BPP exposure was likely within the metabolic capacity of humpback dolphins and thus did not lead to significant accumulation in the blubber. 38…”

Section: Resultsmentioning

confidence: 92%

Alternatives Exert Higher Health Risks than Bisphenol A on Indo-Pacific Humpback Dolphins

Sun,

Guo,

Sun

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

The detrimental effects of bisphenol (BP) exposure are a concern for vulnerable species, Indo-Pacific humpback dolphins (Sousa chinensis). To investigate the characteristics of BP profiles and their adverse impact on humpback dolphins, we assessed the concentrations of six BPs, including bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), bisphenol B (BPB), and bisphenol P (BPP) in blubber (n = 26) and kidney (n = 12) of humpback dolphins stranded in the Pearl River Estuary, China. BPS accounted for the largest proportion of the total bisphenols (∑BPs) in blubber (55%) and kidney (69%). The concentration of ∑BP in blubber was significantly higher than that in the kidney and liver. The EC50 values of five BPA alternatives were lower than those of BPA in humpback dolphin skin fibroblasts (ScSF) and human skin fibroblasts (HSF). ScSF was more sensitive to BPS, BPAF, BPB, and BPP than HSF. The enrichment pathway of BPA was found to be associated with inflammation and immune dysregulation, while BPP and BPS demonstrated a preference for genotoxicity. BPA, BPP, and BPS, which had risk quotients (RQs) > 1, were found to contribute to subhealth and chronic disease in humpback dolphins. According to the EC50-based risk assessment, BPS poses a higher health risk than BPA for humpback dolphins. This study successfully evaluated the risks of bisphenols in rare and endangered cetacean cell lines using a noninvasive method. More in vivo and in field observations are necessary to know whether the BPA alternatives are likely to be regrettable substitutions.

show abstract

Section: Resultsmentioning

confidence: 92%

Alternatives Exert Higher Health Risks than Bisphenol A on Indo-Pacific Humpback Dolphins

Sun,

Guo,

Sun

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Many different PAHs have been detected in marine mammals. 1 Hence it is conceivable that some of the gap between B[ a ]P-EQ chem and B[ a ]P-EQ bio could be closed by additional PAHs, such as alkylated and otherwise substituted PAHs. The accompanying study 3 had not included polychlorinated dibenzodioxins (PCDD) and dibenzofurans (PCDF) as target analytes in the analytical methods.…”

Section: Resultsmentioning

confidence: 99%

“…The beluga whale hunt is not only of tremendous cultural and social value, but also provides an important local source of nutrition. 1…”

Section: Introductionmentioning

confidence: 99%

Mixture effect assessment applying in vitro bioassays to in-tissue silicone extracts of traditional foods prepared from beluga whale blubber

Escher

Binnington

König

et al. 2023

Environ. Sci.: Processes Impacts

View full text Add to dashboard Cite

show abstract

“…PAHs have been widely detected in environmental mediums like water, the atmosphere, sediment, and the biological community [ 6 , 7 ]. Different forms of PAHs pollutants or their metabolites enter into soil, water, the atmosphere and other ecological environment media through evaporation, dissolution, precipitation, photo-oxidation, and biodegradation [ 12 , 13 ], affecting the survival and growth of plants and animals. The absorption and accumulation (biomagnification) of PAHs in the food chain results in potential carcinogenic, teratogenic, and mutagenic risks to humans [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Zhao

Zhou

Zhao

et al. 2022

IJERPH

View full text Add to dashboard Cite

In this study, 16 PAHs were selected as the priority control pollutants to summarize their environmental metabolism and transformation processes, including photolysis, plant degradation, bacterial degradation, fungal degradation, microalgae degradation, and human metabolic transformation. Meanwhile, a total of 473 PAHs by-products generated during their transformation and degradation in different environmental media were considered. Then, a comprehensive system was established for evaluating the PAHs by-products’ neurotoxicity, immunotoxicity, phytotoxicity, developmental toxicity, genotoxicity, carcinogenicity, and endocrine-disrupting effect through molecular docking, molecular dynamics simulation, 3D-QSAR model, TOPKAT method, and VEGA platform. Finally, the potential environmental risk (phytotoxicity) and human health risks (neurotoxicity, immunotoxicity, genotoxicity, carcinogenicity, developmental toxicity, and endocrine-disrupting toxicity) during PAHs metabolism and transformation were comprehensively evaluated. Among the 473 PAH’s metabolized and transformed products, all PAHs by-products excluding ACY, CHR, and DahA had higher neurotoxicity, 152 PAHs by-products had higher immunotoxicity, and 222 PAHs by-products had higher phytotoxicity than their precursors during biological metabolism and environmental transformation. Based on the TOPKAT model, 152 PAH by-products possessed potential developmental toxicity, and 138 PAH by-products had higher genotoxicity than their precursors. VEGA predicted that 247 kinds of PAH derivatives had carcinogenic activity, and only the natural transformation products of ACY did not have carcinogenicity. In addition to ACY, 15 PAHs produced 123 endocrine-disrupting substances during metabolism and transformation. Finally, the potential environmental and human health risks of PAHs metabolism and transformation products were evaluated using metabolic and transformation pathway probability and degree of toxic risk as indicators. Accordingly, the priority control strategy for PAHs was constructed based on the risk entropy method by screening the priority control pathways. This paper assesses the potential human health and environmental risks of PAHs in different environmental media with the help of models and toxicological modules for the toxicity prediction of PAHs by-products, and thus designs a risk priority control evaluation system for PAHs.

show abstract

Polycyclic aromatic hydrocarbons in marine mammals: A review and synthesis

Cited by 20 publications

References 50 publications

Alternatives Exert Higher Health Risks than Bisphenol A on Indo-Pacific Humpback Dolphins

Alternatives Exert Higher Health Risks than Bisphenol A on Indo-Pacific Humpback Dolphins

Mixture effect assessment applying in vitro bioassays to in-tissue silicone extracts of traditional foods prepared from beluga whale blubber

Potential Toxicity Risk Assessment and Priority Control Strategy for PAHs Metabolism and Transformation Behaviors in the Environment

Contact Info

Product

Resources

About