Polycyclic N-Heterocyclic Compounds. Part 65: Ring Cleavage Reactions of Fused Furo[2,3-c]isoquinolines and Related Compounds with Various Nucleophiles

Polycyclic N‐Heterocyclic Compounds, Part 69: Synthesis of 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐d]furo[2,3‐b]pyridines and their transformations to related compounds

“…Reaction of 12 with 2‐aminoethanol in 1,4‐dioxane under reflux afforded the 5‐(2‐hydroxyethylamino) derivative ( 13a ) in 9% yield (Scheme 6). A similar reaction of 12 with 2‐sulfanylethanol afforded 5‐(2‐hydroxyethylsulfanyl) derivative ( 13b ) in 34% along with a 7% yield of the dihydrofuran ring‐cleaved product ( 14 ) [15]. Finally, morpholine was allowed to react with compound 12 and the substitution product 15 was obtained in 46% yield.…”

Polycyclic N‐heterocyclic compounds. Part 66: Synthesis of N‐[2‐([1,2,4]oxadiazol‐5‐yl)cyclopenten‐1‐yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

“…We have previously reported that N- [2-(3- (1) and/or their amide oximes with hydroxylamine hydrochloride followed by pyrimidine ring cleavage and 1,2,4-oxadiazole ring closure (Fig. 1).…”