Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences

Anagnostis, Panagiotis; Tarlatzis, Basil C.; Kauffman, Robert P.

doi:10.1016/j.metabol.2017.09.016

Cited by 282 publications

(217 citation statements)

References 110 publications

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“…PCOS groups showed a statistically significant decreased level of Omentin-1 in obese women when compared to the non-obese women. These results are in agreeing with Anagnostis et al Özgen et al 17,18 . Our results show negative correlation between Omentin-1 and HOMA-IR in PCOS groups.…”

Section: As Shown Insupporting

confidence: 93%

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Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Elhafez¹,

Mohamed²,

Elmouttaleb³

et al. 2020

Int Res J Pharm

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Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in women of reproductive age. Most PCOS patients have a tendency to become obese and insulin resistant. Omentin-1 is an anti-inflammatory adipokine and plays a role in regulating insulin sensitivity. Apelin is a new adipokine which may be a key regulator in glucose and lipid metabolism and may be associated with insulin resistance. This study aimed to evaluate serum levels of Omentin-1 and Apelin to determine their association with obesity and IR in PCOS. A total of eighty subjects divided into four groups: Group I: 20 non-obese control (BMI< 30), Group II: 20 non-obese patient with PCOS (BMI< 30), Group III: 20 obese Control (BMI ≥ 30) and Group IV: 20 obese patient with PCOS (BMI ≥ 30). Serum levels of Insulin, Omentin-1 and Apelin were estimated by ELISA. Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) was calculated. Results showed a significant decrease in serum levels of Omentin-1 and increase in serum levels of Apelinin (non-obese and obese) PCOS groups when compared to their controls. Within PCOS groups there were significant negative correlations between Omentin-1 and both of HOMA-IR and BMI, while there were significant positive correlations between Apelin and both of BMI and HOMA-IR. In summary serum Omentin-1 and Apelin are directly correlated with IR and obesity in women with PCOS.

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Section: As Shown Insupporting

confidence: 93%

“…Many mechanisms have been proposed for the development of IR in PCOS16 . The main one is a post-binding defect in insulin signaling due to increased serine phosphorylation and decreased tyrosine phosphorylation of insulin receptor17 . Approximately 90% of obese women with PCOS and 45% of lean women with PCOS have IR 18 .…”

mentioning

confidence: 99%

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Elhafez¹,

Mohamed²,

Elmouttaleb³

et al. 2020

Int Res J Pharm

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“…In 19 For women with no history of sexual life, abdominal B-ultrasound (frequency of [2][3][4][5] was performed to assess the ovarian morphology; for those with sexual life history, transvaginal ultrasound (frequency of 5-9 MHz) was performed. PCOS was diagnosed if there were >12 follicles and if the diameter of each follicle were 2-9 mm, and/or the ovarian volume was >10 cm 3 .…”

Section: Participantsmentioning

confidence: 99%

“…1,2 The prevalence of PCOS varies between 5% and 15% with ethnicity. PCOS is characterized by hyperandrogenism and anovulatory infertility, and has substantial short-and long-term reproductive, psychological and metabolic implications.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic‐hyperinsulinemic clamps

Chen

Xie

et al. 2018

Clinical Endocrinology

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Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

Krentowska

Kowalska

2021

Diabetes Metabolism Res

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-age women. Important factors in its pathogenesis are hyperinsulinaemia and insulin resistance, which lead to higher risk of metabolic syndrome (MetS) and its complications. With the implementation of the Rotterdam diagnostic criteria in 2003, the group of PCOS patients became highly heterogeneous, with varying metabolic risk reported for different phenotypes of the syndrome. The aim of the present review is to assess the prevalence and severity of MetS and its components in patients with the four phenotypes of PCOS. A comprehensive search of Pubmed database was performed to identify studies comparing metabolic characteristics between PCOS patients with different phenotypes of the syndrome. The results of 60 studies published between 2004 and 2020 were retrieved and analysed. More adverse metabolic profile was observed in PCOS patients with hyperandrogenic phenotypes in comparison to normoandrogenic patients, as well as in classic phenotypes, defined by National Institutes of Health criteria, in comparison to newer phenotypes introduced by the Rotterdam criteria. In the majority of observations, normoandrogenic PCOS patients did not differ significantly from controls in terms of metabolic characteristics, although some East Asian studies reported more adverse metabolic profile in normoandrogenic phenotype in comparison to healthy women. In conclusion, metabolic abnormalities in PCOS seem to be associated with joint effects of hyperandrogenism, insulin resistance and visceral obesity. The differences observed between the four phenotypes of PCOS underline the need for individualised diagnostic and therapeutic approach.

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Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences

Cited by 282 publications

References 110 publications

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Evaluation of Serum Omentin-1 and Apelin Levels and Their Association With Insulin Resistance and Obesity in Egyptian Women With Polycystic Ovary Syndrome

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic‐hyperinsulinemic clamps

Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

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