Polycystic ovarian syndrome: rs1799752 polymorphism of ACE gene

Abstract

SUMMARY PURPOSE: To investigate the contribution of the deletion polymorphism and insertion (rs1799752) of the angiotensin converting enzyme (ACE) gene in the aetiology of Polycystic Ovarian Syndrome (PCOS). METHODOLOGY: 97 women diagnosed with PCOS who received care at the Gynaecology and Obstetrics clinic of the Hospital das Clínicas of UFTM, participated in this study. The control group consisted of 94 women. All participants were submitted to the collection of 10 mL of whole blood and the genomic DNA was obtained by the saline extraction method. The genotyping of the samples was performed by means of the Polymerase Chain Reaction (PCR). The statistics analyses were performed by descriptive analysis, univariate analysis and logistic regression model. The results were presented in odds ratio (OR) and confidence interval of 95% (CI-95%), with a significance level of 5% (p≤0.05). RESULTS: There were no statistical differences between patients and controls for the genotypic (χ2 = 1.52, p = 0.47) and allelic frequencies (χ2 = 0.21, p = 0.76). The distribution of the genotypic frequency is not in HWE for patients (χ2 = 18.80, p <0.05) and for controls (χ2 = 6.85, p <0.05). In relation to the risk factors for the syndrome, the history of familial PCOS is more frequent between women with the syndrome. CONCLUSION: In the study population, there was no association between I/D polymorphism of the ACE gene and PCOS.

Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population

“… 11 , 12 , 13 , 14 , 15 , 16 RAS includes Angiotensin‐Converting Enzyme ( ACE ), the key effector peptide of RAS, converts angiotensin‐I to angiotensin‐II and splits bradykinin into inactive fragments. 11 The alteration of ACE enzyme activity was associated with the development of many diseases such as COVID, 17 , 18 hypertension, and cardiovascular diseases (CVDs), 19 , 20 renal pathology, 21 Alzheimer disease, 22 , 23 polycystic ovarian syndrome, 24 and cancers. 25…”

Angiotensin Converting Enzyme (ACE) Gene I/D Polymorphism Is Significantly Associated with Insulin Resistance and Polycystic Ovary Syndrome: A Meta-Analysis

“…After reviewing all of the publications, duplicated papers, reviews, abstracts, and studies about other SNPs were removed. Then 13 eligible studies with 3,212 PCOS cases and 2,314 controls were included in the following analysis [11,12,[15][16][17][18][19][20][21][22][23][24][25]. The flow of retrieval is shown in Figure 1.…”

“…All of the PCOS cases were diagnosed according to the Rotterdam criteria, and the controls were the healthy females without any manifestation or diagnosis of PCOS. The participants in six studies were Asians from India, China, and Pakistan [11,18,[22][23][24][25], while the other seven were Caucasians from Poland, Brazil, and Turkey [12,[15][16][17][19][20][21]. Only 6 studies had data for T, insulin, HOMA-IR, or LH/FSH.…”