Polycystic ovaries after precocious pubarche: relation to prenatal growth

Ibáñez, Lourdes; Jaramillo, Adriana; Enríquez, Goya; Miró, Elisabet; López‐Bermejo, Abel; Dunger, David B.; Zegher, Francis de

doi:10.1093/humrep/del395

Cited by 74 publications

(32 citation statements)

References 43 publications

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“…However, the number of cases was very small (cases/ controls: 12/12). In contrast, Ibáñez et al [40] showed that women with a history of PA (mean age 28 ± 2 years) have an elevated CIMT compared to age-matched controls. Similarly, we showed that CIMT levels were significantly different in children with PA at diagnosis.…”

Section: Discussionmentioning

confidence: 85%

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Çelik

Alp²,

Çamtosun³

et al. 2016

Horm Res Paediatr

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Aim: The aim of this study was to investigate the cardiovascular risk of children with premature adrenarche (PA). Methods: A total of 75 children (44 with PA and 31 control subjects) aged 6-10 years were included in the study. Their metabolic, anthropometric, and echocardiographic parameters were recorded and compared. Results: Triglyceride, DHEA-SO₄, and 17-hydroxyprogesterone levels were significantly higher in the PA group (p = 0.04, p = 0.002, and p = 0.01, respectively). The echocardiographic assessments revealed that the left ventricular end-diastolic diameter (LVEDD) (p < 0.001), left ventricle (LV) and right ventricle (RV) ejection times (p = 0.031 and p = 0.035, respectively), and LV and RV Tei index measurements (p = 0.033 and p = 0.006, respectively) were significantly higher in the PA group than in the control group, whereas the E/e' ratio of the mitral lateral annulus was significantly lower in the PA group (p = 0.006). Additionally, carotid intima-media thickness and epicardial adipose tissue measurements were significantly increased in the PA group compared to the control group (p < 0.001). Conclusion: Early atherosclerotic changes and subclinical impairment of cardiac function were observed in children with PA. It is possible that these children are on a course for early cardiovascular disease.

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Section: Discussionmentioning

confidence: 85%

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Çelik

Alp²,

Çamtosun³

et al. 2016

Horm Res Paediatr

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“…However, the association was with high birthweight, which was associated with hirsute women with polycystic ovaries who had higher than normal ovarian secretion of androgens (31). Another group in Spain has studied adolescent girls, primarily with premature pubarche, and has consistently found that low birthweight is associated with more severe reproductive and metabolic abnormalities (11,12,(32)(33)(34). Furthermore, these investigators have shown an inverse association between birthweight and ovarian volume, which persists even after excluding those with polycystic ovary morphology (35,36).…”

Section: Discussionmentioning

confidence: 99%

“…First, prenatal exposure to androgens can produce a phenocopy of PCOS in rhesus macaques, sheep and rodents (6 -8), and humans (9,10). Second, several studies in humans have suggested that there is an association between low birthweight and features of PCOS (11)(12)(13). The human studies, however, have been limited by small sample size, incomplete reproductive or metabolic phenotyping, and the lack of family-based comparison groups.…”

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confidence: 99%

Associations of Birthweight and Gestational Age with Reproductive and Metabolic Phenotypes in Women with Polycystic Ovarian Syndrome and Their First-Degree Relatives

Legro

Roller

Dodson

et al. 2010

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context: Low birthweight has been associated with metabolic and reproductive abnormalities in adults.Objective: The aim of the study was to examine the relationship between birthweight and gestational age and its association with reproductive and metabolic phenotypes in women with PCOS and their first-degree relatives. Design and Setting:We conducted a family-based study of PCOS at an academic health center. Patients or Other Participants:A total of 1038 individuals (845 females and 193 males) from the cohort and 168 controls participated in the study. Main Outcome Measures:The association between birthweight and familial phenotype was measured.Results: Self-reported and actual birthweight were highly correlated ͓Spearman correlation coefficient (r) ϭ 0.81; 95% CI, 0.66, 0.89; P ϭ 0.001) and concordant (concordance correlation coefficient ϭ 0.86; 95% lower limit ϭ 0.78). We noted that birthweight for both genders in PCOS families and controls fell within the 10th and 90th percentiles for gestational age based on U.S. population norms. The 50th percentiles for a gestational age of 40 wk were very similar (3409 g in PCOS, 3455 g for controls, and 3495 g for the United States). There were no significant associations between phenotype and birthweight in PCOS probands. Furthermore, there were not any significant relationships between phenotype and birthweight in female or male family members of the PCOS probands.Conclusions: Birthweight in PCOS families mirrors control and U.S. population data, even corrected for gestational age, and has no substantive association with reproductive and metabolic abnormalities in women with PCOS, their female relatives, or their male relatives. (J Clin Endocrinol Metab 95: 789 -799, 2010) P olycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic anovulation, hyperandrogenism, and polycystic ovaries (1). It is associated with metabolic abnormalities including insulin resistance, dyslipidemia, and increased risk for type 2 diabetes (2). The etiology is unknown, although like other complex disorders, there are both genetic and environmental influences (1). Obesity is frequently associated

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“…IUGR followed by catch up growth during childhood increases the risk of precocious pubarche (Ibanez et al 1998a), anovulation PCOS (Ibanez et al 2002b(Ibanez et al , 2007, and characteristics of the metabolic syndrome in adolescence (Ibanez et al 2006a). Insulin resistance has been suggested to be a central driver in these associations and treatment with insulin sensitizers in girls with precocious pubarche has been shown to significantly delay the onset of early menarche in this population (Ibanez et al 2006b(Ibanez et al , 2008a.…”

Section: Establishment Of Female Reproductive Function: a Brief Overviewmentioning

confidence: 99%

“…Although it is clear that intrauterine factors play a significant role in the development of the female reproductive system and the risk of dysfunction later in life (de Zegher & Ibanez 2006, Ibanez et al 2007, Melo et al 2010, Franks & Berga 2011, the causal factors are not still clearly defined (Cresswell et al 1997). In a small population of girls, SGA was associated with an increased risk of developing PCOS (Ibanez et al 1998a(Ibanez et al ,b, 2001(Ibanez et al , 2008b.…”

Section: Establishment Of Female Reproductive Function: a Brief Overviewmentioning

confidence: 99%

Early-life nutritional effects on the female reproductive system

Chan

Tsoulis

Sloboda³

2014

Journal of Endocrinology

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There is now considerable epidemiological and experimental evidence indicating that early-life environmental conditions, including nutrition, affect subsequent development in later life. These conditions induce highly integrated responses in endocrine-related homeostasis, resulting in persistent changes in the developmental trajectory producing an altered adult phenotype. Early-life events trigger processes that prepare the individual for particular circumstances that are anticipated in the postnatal environment. However, where the intrauterine and postnatal environments differ markedly, such modifications to the developmental trajectory may prove maladaptive in later life. Reproductive maturation and function are similarly influenced by early-life events. This should not be surprising, because the primordial follicle pool is established early in life and is thus vulnerable to early-life events. Results of clinical and experimental studies have indicated that early-life adversity is associated with a decline in ovarian follicular reserve, changes in ovulation rates, and altered age at onset of puberty. However, the underlying mechanisms regulating the relationship between the early-life developmental environment and postnatal reproductive development and function are unclear. This review examines the evidence linking early-life nutrition and effects on the female reproductive system, bringing together clinical observations in humans and experimental data from targeted animal models.

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Polycystic ovaries after precocious pubarche: relation to prenatal growth

Abstract: The presence of a PCO morphology in women with a PP history was found to relate to prenatal growth. It would be of interest to verify whether a similar relationship exists in anovulatory and/or hyperandrogenic women without PP history.

Cited by 74 publications

References 43 publications

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Associations of Birthweight and Gestational Age with Reproductive and Metabolic Phenotypes in Women with Polycystic Ovarian Syndrome and Their First-Degree Relatives

Early-life nutritional effects on the female reproductive system

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