Polycystic ovaries at ultrasound: normal variant or silent polycystic ovary syndrome?

Catteau-Jonard, Sophie; Bancquart, J.; Poncelet, E.; Lefebvre-Maunoury, C.; Robin, Geoffroy; Dewailly, Didier

doi:10.1002/uog.11202

Cited by 74 publications

(43 citation statements)

References 26 publications

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“…A recent study made a comparison and suggested that the presence of polycystic ovaries upon ultrasound is not a condition that can be considered normal even when it is not associated with this syndrome [22]. In this study, both HR and PCOS patients had a larger number of follicles after hormonal stimulation than the control group, which appears to not be a physiological condition.…”

Section: Discussionmentioning

confidence: 81%

Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment

Cordeiro

Cataldi

Costa

et al. 2014

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 81%

Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment

Cordeiro

Cataldi

Costa

et al. 2014

J Assist Reprod Genet

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“…On the other hand, some studies have revealed that women having isolated PCO, unlike those with PCOS, do not have altered endocrine and metabolic profile compared to normal controls [12,15,23]. As limited by the retrospective nature of our current study, however, we did not have the metabolic and endocrine data for comparison among the three groups.…”

Section: Discussionmentioning

confidence: 82%

Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Lee

Lau

et al. 2013

J Assist Reprod Genet

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Purpose This retrospective cohort study evaluated the cumulative live birth rate in women with polycystic ovary syndrome (PCOS) and isolated polycystic ovaries (PCO) undergoing in-vitro fertilisation (IVF) treatment. Methods We studied 104 women with PCOS, 184 with PCO and 576 age-matched controls undergoing the first IVF treatment cycle between 2002 and 2009. The main outcome measure was cumulative live birth in the fresh plus all the frozen embryo transfers combined after the same stimulation cycle. Results Women in both the PCOS (n =104) and isolated PCO groups (n =184) had higher ovarian response parameters compared to age-matched controls (n =576), and higher rates of withholding fresh embryo transfer for risk of ovarian hyperstimulation syndrome (OHSS). The actual incidence of moderate to severe OHSS was significantly higher in the PCOS (11.5 %) but not the isolated PCO group (8.2 %) compared to controls (4.9 %). The live birth rates in the fresh cycle were comparable among the 3 groups, but the PCOS group had a significantly higher miscarriage rate compared to the other 2 groups. Cumulative live birth rate was significantly higher in the isolated PCO group (60.3 %), but not the PCOS group (50.0 %), compared to controls (47.5 %).Conclusions Women in the isolated PCO group, but not the PCOS group, had a significantly higher cumulative live birth rate compared to controls. This could be explained by the quantitative effect of the higher number of transferable embryos obtained per stimulation cycle, which is uncompromised by the unfavourable embryo competence otherwise observed in PCOS.

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“…Some hypothesize that PCO alone constitutes the mildest form of PCOS as these women showed intermediate serum anti-Mullerian hormone levels 35 and responses to a gonadotropin-releasing hormone challenge 36 compared to women with Frank PCOS and controls. We noted that women with PCO alone did not differ from controls in their metabolic profile, consistent with previous reports, 12,35 but in contrast to others showing subtle variations in insulin sensitivity and androgen levels. [36][37][38][39][40] It is difficult to fully appreciate discrepancies between studies since they failed to report actual follicle counts or other sonographic end points for their cohorts.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology: An Assessment of Over 100 Consecutive Women Self-reporting Features of Polycystic Ovary Syndrome

et al. 2014

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The prevalence of polycystic ovary syndrome (PCOS) and its distinct clinical phenotypes were assessed using 3 sets of international diagnostic criteria in women self-reporting concerns over outward features of PCOS. Revised ultrasonographic criteria for polycystic ovaries (PCO) based on modern ultrasound technology were used. Of the participants, 53%, 62%, and 70% were diagnosed with PCOS using National Institutes of Health, Androgen Excess and PCOS Society, and Rotterdam criteria, respectively. Prevalence of Frank, Ovulatory, Normoandrogenic, and Non-PCO PCOS were 66%, 13%, 11%, and 9%, respectively. Frank PCOS was associated with the severest metabolic disturbances whereas metabolic profiles in Normoandrogenic PCOS did not differ from controls, supporting reduced health risks in women without androgen excess. Metabolic disturbances and hyperandrogenism were linked to excess adiposity across all the groups. Using updated criteria for PCO, the prevalence of Non-PCO PCOS and PCO alone in healthy women recruited from the general population was reduced compared to the previous reports.

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Polycystic ovaries at ultrasound: normal variant or silent polycystic ovary syndrome?

Abstract: Objective It is not known whether polycystic ovaries (PCO) levels: 5.25 nmol/L, 4.37 nmol/L and 6.09 nmol/L, respectively). Body mass index, waist circumference and insulin levels had no effect on these differences. Conclusion

Cited by 74 publications

References 26 publications

Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment

Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment

Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology: An Assessment of Over 100 Consecutive Women Self-reporting Features of Polycystic Ovary Syndrome

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