Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin

Hooff, M.H.A. van; Voorhorst, Feja J.; Kaptein, M. B. H.; Hirasing, R.A.; Koppenaal, C.; Schoemaker, J.

doi:10.1016/s0015-0282(00)00584-7

Cited by 122 publications

(76 citation statements)

References 53 publications

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“…Moreover, we observed the serum LH concentrations every 10 min for 3 h and found that the 6-week-old PNA rats exhibited increased LH pulse frequency. In previous studies, hyperandrogenemic girls with PCOS exhibited elevated concentrations of serum LH, accompanied by an increase in pulse frequency and amplitude (van Hooff et al 2000).…”

Section: Discussionmentioning

confidence: 76%

Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats

Yan¹,

Yuan²,

Zhao³

et al. 2014

Journal of Endocrinology

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In adolescent girls with polycystic ovary syndrome (PCOS), neuroendocrine derangements manifest after the onset of puberty, characterized by rapid LH pulse frequency. The early mechanism underlying the pubertal regulation of the GNRH/LH pulsatile release in adolescents with PCOS remains uncertain. To determine the effects of prenatal androgen exposure on the activation of GNRH neurons and generation of LH pulse at puberty, we administrated 5a-dihydrotestosterone to pregnant rats and observed serum LH levels and expression of hypothalamic genes in female offspring from postnatal 4 to 8 weeks. The 6-week-old prenatally androgenized (PNA) female rats exhibited an increase in LH pulse frequency. The hypothalamic expression of neurokinin B (Nkb (Tac2)) and Lepr mRNA levels in PNA rats increased remarkably before puberty and remained high during puberty, whereas elevated Kiss1 mRNA levels were detected only after the onset of puberty. Exogenous kisspeptin, NK3R agonist, and leptin triggered tonic stimulation of GNRH neurons and increased LH secretion in 6-week-old PNA rats. Leptin upregulated Kiss1 mRNA levels in the hypothalamus of pubertal PNA rats; however, pretreatment with a kisspeptin antagonist failed to suppress the elevated serum LH stimulated by leptin, indicating that the stimulatory effects of leptin may be conveyed indirectly to GNRH neurons via other neural components within the GNRH neuronal network, rather than through the kisspeptin-GPR54 pathway. These findings validate the hypotheses that NKB and leptin play an essential role in the activation of GNRH neurons and initiation of increased LH pulse frequency in PNA female rats at puberty and that kisspeptin may coordinate their stimulatory effects on LH release.

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Section: Discussionmentioning

confidence: 76%

Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats

Yan¹,

Yuan²,

Zhao³

et al. 2014

Journal of Endocrinology

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“…In a study at BSMMU 50% women had hirsutism 17 . The percentage was more than the present study because asymptomatic women with PCO were included.…”

Section: Discussionmentioning

confidence: 97%

“…In another study, the mean ± SD of age distribution was 21.9 ± 3.06 16 , which is nearer to present study. A recent study showed that the common age of PCO women were 21-25 years 17 . This result is also close to the present study.…”

Section: Discussionmentioning

confidence: 99%

Study of Polycystic Ovaries (PCO) in Mymensingh Medical College Hospital, Bangladesh

Nahar

Yasmin

Pramanik

2015

J. Bangladesh Coll. Phys.

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“…9,10 Conditions associated with polycystic ovaries include gestational diabetes [11][12][13][14] and irregular cycles or oligomenorrhia in girls and young women or in women with gestational diabetes. 12,15,16 The link to alterations in the hypothalamic-pituitary-gonadal axis suggests that ovarian cysts in general, not only in PCOS, may be a marker of hormonal milieu associated with the risk of breast cancer. The literature, however, is limited.…”

mentioning

confidence: 99%

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Knight

John

Milne

et al. 2005

Intl Journal of Cancer

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Ovarian cysts of several types are common in women of reproductive age. Their etiology is not well understood but is likely related to perturbations in the hypothalamic-pituitary-gonadal axis. The relationship of ovarian cysts to breast cancer risk is not known, although a negative association with polycystic ovarian syndrome has been reported. Incident, invasive female breast cancer cases, population-based controls and unaffected sisters of cases were studied from 3 countries participating in the Breast Cancer Family Registry: Melbourne and Sydney, Australia; the San Francisco Bay Area, USA; and Ontario, Canada. Using the same questionnaire, information was collected on self-reported history of ovarian cysts and other risk factors. Analyses were based on 3,049 cases, 2,344 population controls and 1,934 sister controls from all sites combined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using both unconditional and conditional logistic regression using an offset term to account for sampling fractions at 2 of the sites. A significantly reduced risk of breast cancer was observed for women reporting a history of ovarian cysts (OR 5 0.70, 95% CI 0.59-0.82, among all cases and all controls). This risk estimate was similar regardless of control group used, within all 3 sites and in both premenopausal and postmenopausal women (ORs ranging from 0.68-0.75, all 95% CI excluded 1.00). A self-reported history of ovarian cysts was strongly and consistently associated with a reduced risk of breast cancer. Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology. ' 2005 Wiley-Liss, Inc.

show abstract

Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin

Cited by 122 publications

References 53 publications

Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats

Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats

Study of Polycystic Ovaries (PCO) in Mymensingh Medical College Hospital, Bangladesh

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

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