Polycystic Ovary Syndrome: A Changing Perspective

Inappropriate gonadotropin secretion in polycystic ovary syndrome: The relationship with clinical, hormonal and metabolic characteristics

“…그러나, 다낭성난소증후군 환자에서 이러한 부 적절한 성선자극호르몬의 분비 이상은 모든 다낭성난소증후군 환자의 공통된 특성이 아니고 약 50-60% 이하에서 존재하는 것으로 보고되 어 왔다 [6,7].…”

Androgens and human hair growth

“…The mesenchyme derived dermal papilla is believed to play an important role in this system, partly because of the constant proportions of dermal papilla, hair bulb matrix and hair size (Van Scott & Ekel, 1958;Ibrahim & Wright, 1982). Our current understanding of the epithelial-mesenchymal interactions in the hair follicle has been greatly elucidated by an elegant series of experiments by Oliver, Jahoda and colleagues at Dundee University mainly using the large rat vibrissa follicle as a model system (reviewed Oliver & Jahoda, 1988;1989). They have isolated the dermal papilla and by reimplantation experiments shown that it plays a major role in inducing new follicular development and determining the type of follicle and fibre produced; in addition, they have cultured rat dermal papilla cells and demonstrated that they retain inductive capacities when reimplanted in vivo (Jahoda et al, 1984), even promoting hair follicular growth in afollicular rat foot-pad skin (Reynolds & Jahoda, 1992).…”

“…Hirsutism can be idiopathic, that is, with no obvious endocrine abnormality, drug-induced or associated with excess androgen production, virilism and endocrine abnormalities of the ovary or adrenal (Karpas, 1987); polycystic ovarian disease is frequently associated with hirsutism (reviewed Franks, 1989). The aetiology of 'idiopathic' hirsutism is unclear, but must involve increased availability of androgens (when it is not truely idiopathic) and/or an increased sensitivity of the hair follicle to normal levels of androgens.…”

Análisis De Resistencia Insulínica, Tolerancia a La Glucosa Y Testosterona en Mujeres Jóvenes Con Síndrome De Ovario Poliquístico Agrupadas Por Índice De Masa Corporal

“…Algunos estudios han demostrado que al menos 50% del total de pacientes con SOP presenta obesidad (1, 16,17), siendo ésta predominantemente de tipo andrógena o central, manifestándose por un índi-ce cintura/cadera aumentado (>0,85). Este tipo de obesidad se ha asociado con hiperandrogenemia, RI, baja tolerancia a la glucosa (BTG) y dislipidemia (18)(19)(20)(21). Además, se ha observado una fuerte asociación entre SOP y alteraciones metabólicas; ≈40% de las pacientes presenta BTG (15), 50% presentaría RI (2,22), y hasta un 10 a 15% presentará diabetes mellitus tipo II hacia la cuarta década de vida (23,24).…”