Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Yau, Tiffany Tl; Ng, Noel Yh; Cheung, Liana; Ma, Rong

doi:10.12809/hkmj176308

Cited by 27 publications

(28 citation statements)

References 90 publications

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“…Hirsutism is found in 70% of women with PCOS 18. Approximately 80% to 85% of women with hyperandrogenism clinically have PCOS 19. We used hirsutism score as a diagnostic criteria of clinical hyperandrogenism and 85% (60 out of 70) patients in our study had hirsutism.…”

Section: Discussionmentioning

confidence: 99%

Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters

Khan

Karim²,

Ainuddin³

et al. 2019

Pak J Med Sci

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Objective: To evaluate the correlation between clinical hyperandrogenism-hirsutism assessed by modified Ferriman-Gallwey (F-G) score, anthropometric, metabolic and endocrine parameters among PCOS infertile women. Methods: This observational study after approval of FRC & ERC of BUMDC was conducted from September 2018-March 2019. It included seventy women aged 20-40 years who presented in infertility clinic of a local Hospital in Karachi. After written informed consent participants were enrolled as per the inclusion criteria of the study and evaluated for cyclical pattern (oligomenorrhoea, amenorrhoea, polymenorrhea), physical (weight, height, BMI), anthropometric, (waist circumference, hip circumference, waist to hip ratio, hirsutism), metabolic (carbohydrate, lipid & protein) and endocrine parameters (serum FSH, LH, LH/FSH ratio, serum testosterone, prolactin and progesterone level). Hirsutism was assessed by visual method through modified F-G score and Pearson correlation was determined between hirsutism and other study parameters. Results: A positive Pearson correlation is found between hirsutism and body weight, BMI, waist and hip circumference, waist to hip ratio (WHR), very low density lipoprotein, cholesterol, triglycerides and testosterone levels. Conclusion: Hirsutism has correlation with anthropometric, metabolic and hyperandrgenic disorders in PCOS infertile women as assessed by modified F-G score. doi: https://doi.org/10.12669/pjms.35.5.742 How to cite this:Khan A, Karim N, Ainuddin JA, Fahim MF. Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.742 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters

Khan

Karim²,

Ainuddin³

et al. 2019

Pak J Med Sci

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“…Glucose homeostatic disorders (impaired and frank diabetes) seem to cluster among patients with PCOS. 3,15 Several rates of these glucose disorders have been documented by different authors using different criteria in the literature, but the rates ranged from 30%-40%. 16 In this present study, we had evaluated these disorders of glucose metabolism using fasting plasma glucose and observed a 49.1% rate of these glucose homeostatic abnormalities among the present study population which is higher than the rates reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Relationship between glucose homeostatic disorders and testosterone in adult Nigerian women with polycystic ovary syndrome

Amadi

Green

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovary syndrome (PCOS) is associated with hyperandrogenemia which is hypothesized to induce glucose homeostastic disorders among women with the syndrome. This study was thereby set to investigate the status of glucose homeostatic disorders and their relationship with testosterone among women with PCOS in Port Harcourt, Nigeria.Methods: This was a retrospective study of 224 women with PCOS who had visited a tertiary hospital in Nigeria over a 10-year period. The laboratory characteristics of these patients were evaluated. Records on age, fasting plasma glucose (FPG) and serum total testosterone (TT) were collected and analyzed using Shapiro-Wilk, descriptive, chi-square, Fisher’s exact, two-way analysis of variance, and Pearson’s tests. A p-value <0.05 was considered significant.Results: Glucose homeostatic disorders were documented in 49.1% of the study population. Impaired fasting glucose (IFG) and diabetes mellitus (DM) was observed among 37.5% and 11.6% of the study population respectively. There was difference in the mean TT levels among those with normal FPG, IFG, and DM (P<0.001). Those with DM had higher TT levels (2.47 ± 0.83 nmol/l) than those with IFG (2.12 ± 0.63 nmol/l) and normal glucose homeostatic status (1.63 ± 0.47 nmol/l). TT correlated positively with FPG among the overall study population (r=0.465; p-value = < 0.001), among those with IFG (r = 0.591; p-value=0.004), and among those with DM (r=0.404; p-value =0.012).Conclusions: Glucose homeostatic disorders are common among PCOS patients in our environment, especially among those with higher testosterone levels. This warrants screening of all PCOS patients for glucose disorders as part of their management strategies.

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“…The Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, 2 with an estimated prevalence of 6 to 10% in this population. 3 According to the Rotterdam criteria, PCOS is diagnosed in the presence of at least two of the three criteria: menstrual disorders or amenorrhea with chronic lack of ovulation, clinical and/or biochemical characteristics of hyperandrogenism and the presence of polycystic ovaries on ultrasonography after exclusion of other endocrine disorders.…”

mentioning

confidence: 99%

“…4 Overall, SOP has been considered a reproductive disorder; however, it also represents a significantly increased risk for cardiometabolic disorders. 2 The impact on reproduction is predominant during the reproductive years, while cardiometabolic alterations become more important in the later stages of a woman's life. 2…”

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confidence: 99%

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Polycystic Ovary Syndrome and Cardiovascular Diseases: Still na Open Door

Malachias

2019

Arquivos Brasileiros De Cardiologia

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Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Cited by 27 publications

References 90 publications

Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters

Polycystic Ovarian Syndrome: Correlation between clinical hyperandrogenism, anthropometric, metabolic and endocrine parameters

Relationship between glucose homeostatic disorders and testosterone in adult Nigerian women with polycystic ovary syndrome

Polycystic Ovary Syndrome and Cardiovascular Diseases: Still na Open Door

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