2010
DOI: 10.1186/1741-7015-8-41
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Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan

Abstract: Polycystic ovary syndrome (PCOS) is of clinical and public health importance as it is very common, affecting up to one in five women of reproductive age. It has significant and diverse clinical implications including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, adverse cardiovascular risk profiles) and psychological features (increased anxiety, depression and worsened quality of life). Polycystic ovary syndrome is … Show more

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Cited by 1,161 publications
(1,007 citation statements)
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References 80 publications
(122 reference statements)
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“…Insulin resistance is associated with obesity, type II diabetes and deranged lipid profile. The symptoms and severity of the syndrome vary greatly by factors such as obesity, genetic, racial predisposition, geographic diversity and lifestyle factors [3]. Therefore, the aim of this study was to evaluate the prevalence of different phenotypes of PCOS and analyze their endocrine and metabolic characteristics including insulin resistance and metabolic syndrome compared to non-PCOS controls in women presenting to a tertiary care center of Delhi.…”
Section: Introductionmentioning
confidence: 99%
“…Insulin resistance is associated with obesity, type II diabetes and deranged lipid profile. The symptoms and severity of the syndrome vary greatly by factors such as obesity, genetic, racial predisposition, geographic diversity and lifestyle factors [3]. Therefore, the aim of this study was to evaluate the prevalence of different phenotypes of PCOS and analyze their endocrine and metabolic characteristics including insulin resistance and metabolic syndrome compared to non-PCOS controls in women presenting to a tertiary care center of Delhi.…”
Section: Introductionmentioning
confidence: 99%
“…Genetic predisposition to PCOS has been established but the relative contribution of genetic and environmental entities underlying this multifactorial disorder remains elusive [8]. Many women with PCOS have insulin resistance (IR), which is now considered a major contributor to the pathogenesis of this disorder [29]. Hyperinsulinemia induces excess ovarian androgen production that affects follicular development leading to chronic anovulation and compromised fertility [2].…”
Section: Introductionmentioning
confidence: 99%
“…PCOS affects approximately 5-10 % of women worldwide, and accounts for the estimated majority of cases of anovulatory infertility in the US [4,6,14]. Though its exact definition remains controversial, consensus remains that the condition is characterized by menstrual irregularities such as oligo-or anovulation, evidence of hyperandrogenism, and polycystic ovaries [4,6,14].…”
Section: Introductionmentioning
confidence: 99%
“…Though its exact definition remains controversial, consensus remains that the condition is characterized by menstrual irregularities such as oligo-or anovulation, evidence of hyperandrogenism, and polycystic ovaries [4,6,14]. Treatment modalities for infertility in this patient population are varied, and historically have included behavioral health modifications including diet and exercise, ovulation induction with clomiphene citrate, metformin, gonadotropins, or aromatase inhibitors, laparoscopic electrosurgery of the ovaries, or IVF/ICSI [4,6,14]. Because of the large range of historical and current treatments for PCOS, consensus on the most appropriate treatments for PCOS as it relates to infertility is somewhat lacking.…”
Section: Introductionmentioning
confidence: 99%