Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention

Osibogun, Olatokunbo; Ogunmoroti, Oluseye; Michos, Erin D.

doi:10.1016/j.tcm.2019.08.010

Cited by 271 publications

(186 citation statements)

References 47 publications

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“…The risk of cardiovascular disease in PCOS patients should also not be ignored. As PCOS is closely related to IR, this can lead to a variety of abnormalities, such as hypertension, glucose intolerance, diabetes, metabolic syndrome, and dyslipidemia, which increase the risk of cardiovascular disease in women (51).…”

Section: Discussionmentioning

confidence: 99%

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis

et al. 2021

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Levels of circulating adipokines in nonobese polycystic ovary syndrome (PCOS) patients have been reported in many studies. However, the results are inconsistent. The aim of this meta-analysis is to assess whether the levels of circulating adipokines are changed in nonobese PCOS relative to nonobese healthy controls. To identify eligible studies, a literature research was performed in the PubMed, Embase, and Web of Science databases without restricting by region, journal, or language. A total of 81 studies met the eligibility criteria. The meta-analysis showed that the circulating level of adiponectin (standardized mean difference [SMD]: -0.95; 95% CI: -1.36 to -0.53) was significantly decreased in nonobese PCOS patients. In contrast, the circulating levels of chemerin (SMD: 1.13; 95% CI: 0.08 to 2.18), leptin (SMD: 0.47; 95% CI: 0.13 to 0.81), resistin (SMD: 0.45; 95% CI: 0.03 to 0.88), and visfatin (SMD: 1.38; 95% CI: 0.68 to 2.09) were significantly increased in nonobese PCOS patients. There were no significant changes in the circulating levels of apelin (SMD: 0.32; 95% CI: -1.34 to 1.99), irisin (SMD: 1.01; 95% CI: -0.68 to 2.70), omentin (SMD: -0.37; 95% CI: -1.05 to 0.31), or vaspin (SMD: 0.09; 95% CI: -0.14 to 0.32). Thus, scientific evidence suggests that the circulating adipokine levels are altered in nonobese PCOS patients compared to nonobese healthy controls. Therefore, independent of the degree of obesity, dysregulated circulating adipokine levels might play important roles in the occurrence and development of PCOS.

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Section: Discussionmentioning

confidence: 99%

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis

et al. 2021

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“…There should be an annual monitoring of glucose, lipid profiles, blood pressure, and weight in these women. All providers engaged in the multidimensional care of women with PCOS should be alarmed of these long-term health risks to provide appropriate screening, counseling, and management options (12).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that almost all cardiovascular risk factors including IR, diabetes mellitus (DM), dyslipidemia, obesity, hypertension, and metabolic syndrome are associated with PCOS (4)(5)(6)(7)(8). These risk factors are present even in young patients with PCOS and predispose to the development of endothelial dysfunction, early atherosclerosis and cardiovascular disease (CVD) (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Hypertension Risk in Young Women With Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study

Chiu

Chang

et al. 2020

Front. Med.

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“…Women diagnosed with polycystic ovarian syndrome (PCOS), an endocrine disorder characterized by high AMH levels, hyperinsulinemia, amenorrhea or oligomenorrhea, and hyperandrogenism, also present with unfavorable lipid profiles, hypertension, subfertility, higher fasting insulin levels and arterial stiffness, and have a higher risk for developing CVD ( 21 , 44 ). Studies have shown that carotid intima-media thickness is higher in women with PCOS compared to age and BMI-matched controls, thus it may be a useful measurement for defining subclinical atherosclerotic progression and may serve as an outcome for lifestyle interventions in this population ( 22 ).…”

Section: Subfertility In Reproductive Aged Women and Vascular Structumentioning

confidence: 99%

Importance of Sensitive Vascular Measurements for Evaluating Effects of Lifestyle in Premenopausal Women

Lane‐Cordova

Bouknight

2020

Front. Cardiovasc. Med.

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Premenopausal women generally have a favorable cardiovascular risk profile, owing to young age and the protective effects of estrogen. Rates of hypertension and more advanced cardiovascular disease (CVD) are low in premenopausal women. A large body of epidemiological evidence has shown that lifestyle behaviors in midlife, i.e., cardiorespiratory fitness, physical activity, and healthy diet, are associated with lower risk of overt CVD and adverse cardiovascular outcomes in the future for men and women. Despite differences in future cardiovascular risk, brachial blood pressures might be similar between premenopausal women with favorable vs. unfavorable levels of lifestyle behaviors in early-to-mid-life. Here we make the case for deeper phenotyping by means of vascular function measurements, such as arterial stiffness, augmentation index, and endothelial function, to identify potential mechanistic pathways linking lifestyle behaviors in early-to-mid-adulthood with lifelong CVD risk in women. We describe considerations for vascular function measurement in premenopausal women and opportunities for investigators to fill in knowledge gaps to further our understanding of CVD risk assessment and CVD progression in premenopausal women.

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Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention

Cited by 271 publications

References 47 publications

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis

Hypertension Risk in Young Women With Polycystic Ovary Syndrome: A Nationwide Population-Based Cohort Study

Importance of Sensitive Vascular Measurements for Evaluating Effects of Lifestyle in Premenopausal Women

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