Polycystic ovary syndrome and chronic autoimmune thyroiditis

Novais, Jussara de Souza Mayrink; Benetti‐Pinto, Cristina Laguna; Garmes, Heraldo Mendes; Jales, Rodrigo Menezes; Juliato, Cássia Raquel Teatin

doi:10.3109/09513590.2014.958990

Cited by 26 publications

(30 citation statements)

References 21 publications

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“…By comparing the nationwide Danish population of PCOS with a large control group, Glintborg et al [19] recently reported a significantly increased prevalence for diseases such as diabetes, thyroid disease and asthma. In the literature, high prevalence of autoimmune thyroiditis was also observed in PCOS patients [20–24]. We think that our EWAS results based on DNA methylation profiling provide strong molecular evidence for the epidemiological findings based on clinical data.…”

Section: Discussionsupporting

confidence: 73%

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Zhu

Duan

et al. 2016

Oncotarget

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As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes reflecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from interference of the genome with the environment through integrative biological mechanisms including epigenetics. We have performed a genome-wide DNA methylation analysis on polycystic ovarian syndrome and identified a substantial number of genomic sites differentially methylated in the whole blood of PCOS patients and healthy controls (52 sites, false discovery rate < 0.05 and corresponding p value < 5.68e–06), highly consistently replicating biological pathways extensively implicated in immunity and immunity-related inflammatory disorders (false discovery rate < 0.05) that were reportedly regulated in the DNA methylome from ovarian tissue under PCOS condition. Most importantly, our genome-wide profiling focusing on PCOS patients revealed a large number of DNA methylation sites and their enriched functional pathways significantly associated with diverse clinical features (levels of prolactin, estradiol, progesterone and menstrual cycle) that could serve as novel molecular basis of the clinical heterogeneity observed in PCOS women.

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Section: Discussionsupporting

confidence: 73%

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Zhu

Duan

et al. 2016

Oncotarget

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“…Correspondingly, prescriptions of thyroid medicine were three times increased in PCOS. These data are in agreement with clinical studies reporting that thyroid autoantibodies and autoimmune thyroiditis were more prevalent in patients with PCOS compared with controls (16,38). These findings lead to a hypothesis of altered immune function in PCOS, which could be mediated by increased inflammatory status, unbalanced estrogen/progesterone secretion, or still unknown mechanisms (16).…”

Section: European Journal Of Endocrinologysupporting

confidence: 82%

Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome

Glintborg

Rubin

Nybo

et al. 2015

European Journal of Endocrinology

132

168

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Objective: The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS. Design: A National Register-based study. Methods: Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH, nZ1217). PCOS Denmark (nZ19 199) included women with PCOS in the Danish National Patient Register. Three age-matched controls were included per patient (nZ57 483). Main outcome measures: Diagnosis codes and filled prescriptions. Results: The mean (range) age of the PCOS Denmark group and controls was 30.6 (12-60) years. Patients in PCOS Denmark had higher Charlson index, higher prevalence of diabetes, dyslipidemia, and hypertension than controls. PCOS was associated with a two times increased risk of stroke and thrombosis, whereas the risk of other cardiovascular diseases was not increased. Thyroid disease, asthma, migraine, and depression were more prevalent in PCOS Denmark vs controls, whereas fractures were rarer. Infertility was increased in patients compared with controls, but the mean number of births was higher in PCOS. Medicine prescriptions within all diagnosis areas were significantly higher in PCOS patients than in controls. In PCOS OUH, polycystic ovaries (PCO) and irregular menses were associated with a more adverse metabolic risk profile, but individual Rotterdam criteria were not associated with cardiometabolic diagnoses. Conclusion: Cardiometabolic and psychiatric morbidity were significantly increased in a Danish population with PCOS. Medical diseases are frequent also in young patients with PCOS.

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“…In a recent register-based study, the overall presence of thyroid diseases was 3.6 times increased in PCOS versus controls and prescriptions of thyroid medicine were three times increased in patients (7). These data were in agreement with clinical studies reporting that presence of thyroid autoantibodies and autoimmune thyroiditis was more prevalent in patients with PCOS compared with controls (99,100). Similar mechanisms were suggested to affect respiratory health and to increase the risk of asthma in women with irregular menses (101).…”

Section: Autoimmune Inflammatory and Infectious Diseases In Pcossupporting

confidence: 79%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Polycystic ovary syndrome and chronic autoimmune thyroiditis

Abstract: AIT risk was similar in the PCOS and the non-PCOS group. SCH are more common in women with PCOS, highlighting a need for periodic monitoring of thyroid function.

Cited by 26 publications

References 21 publications

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

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