Polycystic ovary syndrome and endometrial carcinoma

Hardiman, Paul; Pillay, Ouma S; Atiomo, William

doi:10.1016/s0140-6736(03)13409-5

Cited by 358 publications

(210 citation statements)

References 13 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…Several of these findings are common in PCOS, it was therefore speculated that PCOS patients carry an increased risk of endometrial cancer, but data from epidemiological studies were conflicting (121). In some study populations the risk of endometrial cancer in PCOS was three to four times increased, whereas this could not be confirmed in other studies (120,122,123).…”

Section: Cancer Diseasementioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

show abstract

Section: Cancer Diseasementioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Inter-individual variation is commonly observed with respect to clinical features changing throughout the life span, starting from adolescence to postmenopausal age. Thus, predisposing the individual to serious long term consequences such as type 2 diabetes, endometrial hyperplasia, thyroid dysfunction and cardiovascular diseases [4][5][6][7][8]. Wild et al (2000) reported that women with previous history of PCOS have a higher prevalence of hypertension and other cardiovascular diseases later in life than the controls [9].…”

Section: Introductionmentioning

confidence: 99%

Do ACE I/D gene polymorphism serve as a predictive marker for age at onset in PCOS?

Deepika

Reddy

Rani³

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Background Polycystic ovary syndrome (PCOS) is an endocrine disorder exhibiting variable age at onset of clinical features allied with complex diseases in the later life. ACE is a pleiotropic molecule associated with various pathophysiological functions. The present study was aimed to establish the frequency of ACE I/D gene polymorphism in patients and controls and to assess the influence of this polymorphism on anthropometric and various clinical features of the condition. Methods ACE I/D genotyping was carried out in 259 PCOS patients and 315 healthy ultrasound scanned women of South Indian origin.Results The distribution of DD, ID and II genotypes in patients was 39, 37 and 24 %, whereas in the controls it was 31, 51 and 18 % respectively. Significant difference was observed in the genotypic frequency distributions between the patients and controls, however the allelic frequencies did not vary between the groups (p>0.05). Quartile analysis revealed preponderance of DD genotype in the first two quartiles and a linear increase of II genotype from first to the last quartiles. Further, Multiple Logistic regression analysis revealed significant association of ACE I/D gene polymorphism with acanthosis and age at onset (AAO) of the syndrome (p<0.05). Conclusion The present study is the first report to highlight the predisposing role of DD and protective role of ID genotype towards PCOS. Patients with single or double dose of D allele may develop PCOS symptoms at an early age and also significantly associated with acanthosis, a marker of insulin resistance.

show abstract

“…In vitro studies have shown an abnormal steroidogenic phenotype in isolated theca cell culture (17). According to the third hypothesis, insulin resistance and hyperinsulinemia are important factors in steroidogenic dysfunction in PCOS (18,19 (14,26) and increased cardiovascular risk (27)(28)(29). An atherogenic lipid profile is observed as a result of increased LDL cholesterol, increased triglyceride levels and decreased HDL cholesterol levels in these patients (30)(31)(32).…”

Section: Review 168mentioning

confidence: 99%