Polycystic Ovary Syndrome and Migraine Headache, Is There Any Correlation?

Pourabolghasem, Shabnam; Najmi, Safa; Arami, Mohammad Ali

doi:10.1159/000165349

Cited by 10 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, women with PCOS ex pe ri enced head ache more fre quently than con trol women: 68.4% vs. 50.0%, p=0.010. We found only one study re lated to head ache in women with PCOS that showed lower rates of head ache in PCOS and con trols com pared with our re sults, re spectively 44.9% in women with PCOS and 33.8% in con trols [10]. Pourabolghasem et al also found no sig nif i cant differ ence of head ache fre quency be tween women with PCOS and con trols (OR=0.78, CI: 0.6-1.03, p=0.81) [10].…”

Section: Discussionsupporting

confidence: 81%

“…We found only one study re lated to head ache in women with PCOS that showed lower rates of head ache in PCOS and con trols com pared with our re sults, re spectively 44.9% in women with PCOS and 33.8% in con trols [10]. Pourabolghasem et al also found no sig nif i cant differ ence of head ache fre quency be tween women with PCOS and con trols (OR=0.78, CI: 0.6-1.03, p=0.81) [10]. Our re sults showed the op po site: PCOS in creased the odds ra tio for head ache by 2.17 (CI: 1.20-3.91, p=0.010).…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Impact of headache in women with polycystic ovary syndrome

Zabulienė¹,

Hendrixson²,

Urbonas³

et al. 2021

View full text Add to dashboard Cite

Įvadas. Policistinių kiaušidžių sindromas (PKS) yra viena dažniausių vaisingo amžiaus moterų endokrininių, metabolinių ir androgenų perteklių sukeliančių ligų. Pasaulyje 46 % suaugusiųjų vargina galvos skausmas. PKS ir migrenos patogenezė glaudžiai susijusi su atsparumu insulinui. Tyrimų, nagrinėjančių moterų, sergančių PKS, galvos skausmų sąsajas, nėra daug. Šio tyrimo tikslas buvo įvertinti pacienčių, sergančių PKS, galvos skausmo dažnį, jo sąsajas su medžiagų apykaitos rodikliais ir poveikį kasdienei veiklai. Tyrimo metodai. 114 moterų, sergančių PKS (pagal Roterdamo kriterijus), ir 80 sveikų moterų, kurios neturėjo klinikinių ar biocheminių hiperandrogenizmo požymių, policistinių kiaušidžių ir kurių mėnesinės buvo reguliarios, buvo įtrauktos į tyrimą. Tiriamosioms buvo išmatuotas ūgis, svoris, kraujospūdis, apskaičiuotas kūno masės indeksas (KMI), atliktas bendras kraujo tyrimas, gliukozės, insulino koncentracijos nevalgius tyrimas, lipidograma, išsamūs hormonų tyrimai. Dalyvės užpildė klausimyną apie galvos skausmą. Rezultatai. 60,8 % tirtų moterų skundėsi galvos skausmu. Moterys, sergančios PKS, galvos skausmą patyrė dažniau nei kontrolinės grupės pacientės (atitinkamai 68,4 ir 50,0 %, p = 0,010). Sirgimas PKS galvos skausmo šansų santykį padidino 2,17 karto (95 % PI: 1,20-3,91, p = 0,010), o sergančioms PKS moterims antsvoris ar nutukimas galvos skausmo šansų santykį padidino 2,5 karto (95 % PI: 1,11-5,61, p = 0,026). 24,6 % moterų, serganči0 PKS, ir 11,2 % sveikų moterų teigė, kad galvos skausmas riboja jų kasdienę veiklą (p = 0,020). 31,6 % PKS sergančių moterų ir 18,8 % sveikų moterų nurodė, kad galvos skausmas neigiamai veikia jų profesinį gyvenimą (p = 0,046). Išvados. Policistinių kiaušidžių sindromu sergančias moteris, ypač turinčias antsvorį ar nutukusias, dažnai vargina galvos skausmas, kuris neigiamai veikia jų profesinį gyvenimą ir kasdienę veiklą.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 81%

Impact of headache in women with polycystic ovary syndrome

Zabulienė¹,

Hendrixson²,

Urbonas³

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Only patients with normal MRI findings (established by a neuroradiologist with 10+ years of experience) and no diagnosis of a disease associated with affliction of the endocrine axis were included. 14,15 According to these criteria, we could include a total of 144 patients. The most common indication for the MRI examination was headache.…”

Section: Methodsmentioning

confidence: 99%

Obesity and pituitary gland volume – a correlation study using three-dimensional magnetic resonance imaging

et al. 2020

View full text Add to dashboard Cite

Purpose Obesity has become a major health problem and is associated with endocrine disorders and a disturbed hypothalamic-pituitary axis. The purpose of this study was to correlate pituitary gland volume determined by routine magnetic resonance imaging with patient characteristics, in particular body mass index and obesity. Material and methods A total of 144 ‘healthy’ patients with normal findings in cerebral magnetic resonance imaging were retrospectively included. Pituitary gland volume was measured in postcontrast three-dimensional T1-weighted sequences. A polygonal three-dimensional region of interest covering the whole pituitary gland was assessed manually. Physical characteristics (gender, age, body height and body mass index) were correlated with pituitary gland volume. Multiple subgroup and regression analyses were performed. Results Pituitary gland volumes were significantly larger in females than in males ( p<0.001) and young individuals (<35 years) versus middle-aged patients (35–47 years) ( p=0.042). Obese patients (body mass index ≥30) had significantly larger pituitary gland volumes than overweight (25<body mass index<30; p=0.011) and normal-weight (body mass index <25; p=0.005) patients. In males, pituitary gland volumes of body mass index subgroups showed significant differences ( p=0.038). Obese males had larger pituitary gland volumes than overweight patients ( p=0.066) and significantly larger volumes than normal-weight ( p=0.023) patients. Obese females also had larger pituitary gland volumes but without statistical significance ( p>0.05). Regression analysis showed that increased pituitary gland volume is associated with higher body mass index independent from gender, age and body height. Conclusion Pituitary gland volume is increased in obese individuals and a high body mass index can be seen as an independent predictor of increased pituitary gland volume. Therefore, gland enlargement might be an imaging indicator of dysfunction in the hypothalamus-pituitary axis. Besides gender and age, body mass index should be considered by radiologists when diagnosing abnormal changes in pituitary gland volume.

show abstract

“…Especially in women, oestrogen fluctuations are identified as a risk factor of migraine and migraine attacks [56]. Pourabolghasem et al suggested that there is no evidence that higher levels of male sex hormones (mainly testosterone) in female migraineurs with polycystic ovary syndrome (PCOS) intensify migraine attacks [59]. Glintborg et al reported that migraine was more prevalent in PCOS females [60].…”

Section: Discussionmentioning

confidence: 99%

Prenatal oestrogen-testosterone balance as a risk factor of migraine in adults

et al. 2021

View full text Add to dashboard Cite

Background Migraine is a common neurological disease with extremely debilitating, but fully reversible symptoms. Women suffer from migraine more often than men. It was assumed that fluctuation of oestrogen level during menstrual cycle is one of many factors responsible for more frequent migraine attacks. The second-to-fourth digit ratio (2D:4D) is considered as an indicator of prenatal sex steroids. Balance of prenatal androgens (testosterone) and oestrogen has been studied in numerous diseases that are affected by hormones. However, the relationship between migraine and the sex steroids balance in prenatal development is still unexplained. The aim of this paper is to provide an evidence of relationship between prenatal oestrogen and testosterone exposure following 2D:4D digit ratio, and migraine prevalence in adults. Methods We examined a group of 151 adults (33 males, 118 females) with migraine and a control group of 111 adults (45 males, 66 females). 2D:4D digit ratio of both hands was measured using sliding Vernier calliper. Results Significant differences were found in the right hand. Female migraineurs had lower value of 2D:4D ratio than the control group and the right 2D:4D was lower than left 2D:4D (Δ2D:4D), suggesting prenatal testosterone dominance. The opposite relationship was observed in males. Male migraineurs had higher value of 2D:4D ratio and Δ2D:4D was greater than the control group, suggesting prenatal oestrogen dominance. Conclusions Our results suggest that depending on sex, different proportion of prenatal sex steroids might be a risk factor of migraine in adults. Women with migraine were presumably exposed in prenatal life to higher testosterone levels relative to oestrogen, while men with migraine were probably exposed in prenatal life to higher levels of oestrogen relative to testosterone.

show abstract

Polycystic Ovary Syndrome and Migraine Headache, Is There Any Correlation?

Cited by 10 publications

References 19 publications

Impact of headache in women with polycystic ovary syndrome

Impact of headache in women with polycystic ovary syndrome

Obesity and pituitary gland volume – a correlation study using three-dimensional magnetic resonance imaging

Prenatal oestrogen-testosterone balance as a risk factor of migraine in adults

Contact Info

Product

Resources

About