Polycystic ovary syndrome and risk of uterine leiomyomata

Abstract

The present study suggests a positive association between PCOS and UL in African-American women.

Testosterone dependent androgen receptor stabilization and activation of cell proliferation in primary human myometrial microvascular endothelial cells

“…Myomatous tissue is known to expand faster than normal myometrium, requiring enhanced vascular proliferation (29). A positive association between uterine leiomyomata and polycystic ovary syndrome as a disease with elevated androgen levels has been published previously (30). It has been demonstrated in rats that supraphysiologic administration of androgens also significantly increases uterine weight and myometrial thickness (31).…”

Sarcoidosis in Black Women in the United States

“…70 peer-reviewed manuscripts, including etiologic analyses of breast cancer, [18][19][20][21][22][23][24] hypertension, 25,26 type 2 diabetes, [27][28][29][30][31] and uterine fi broids. [32][33][34][35] …”

Fibroid growth and medical options for treatment

“…Risk factors for developing fibroids, apart from ethnic origin and heredity, include situations causing prolonged high exposure to estrogens and/or progesterone, such as early age of menarche (5,6), polycystic ovary syndrome (7), obesity (8), and late pregnancy (9). Consistent with these epidemiologic data, the best known stimulator of tumor growth is the combined action of estrogens and progesterone.…”

“…In women of African origin, fibroids occur early in their reproductive life, they are more often numerous and larger in size, recurrence occurs more often, and they do not regress after menopause (47). Other risk factors identified in this population (7,(48)(49)(50)(51)(52) include age, early menarche, overweight, and polycystic ovary syndrome. Tumoral molecular biology studies suggest that E 2 metabolism may be altered in women of African origin, because polymorphism in the catecholamine-O-methyl transferase (COMT) gene leading to reduced enzyme activity has been correlated with increased tumor size (53).…”