Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies

Abstract

The purpose of the study is to examine the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on selected indicators of in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment success. A retrospective cohort study was conducted using existing data on 69 IVF/ICSI treatment cycles undergone by PCOS women and an individually matched sample of 69 IVF/ICSI treatment cycles undergone by non-PCOS women at a major fertility treatment center. BMI (kg/m 2 ) was analyzed as a continuous and categorical (< 25, 25−29.9 ≥ 30) variable. Results indicated that PCOS was directly associated with the number of oocytes retrieved. Irrespective of PCOS status, continuous BMI was inversely associated with total and mature oocytes retrieved. Multiple linear regression analyses indicated no significant effects of PCOS or continuous BMI on the number of mature oocytes fertilized per mature oocyte retrieved or inseminated. Similarly, multiple logistic regression analyses suggested no significant effect of PCOS and continuous BMI on the odds of pregnancy, miscarriage or live birth. Furthermore, categorical BMI did not influence process and outcome measures of IVF/ICSI treatment success. PCOS and continuous BMI appear to have significant and distinct effects on early stages but not on later stages of IVF/ICSI treatment.

Is a premature rise in luteinizing hormone in the absence of increased progesterone levels detrimental to pregnancy outcome in GnRH antagonist in vitro fertilization cycles

“…Furthermore, when the patient diagnosis was added to our logistic regression model predicting pregnancy outcome, it did not influence the adjusted odds ratio for ongoing pregnancy rate. Additionally, recent studies have demonstrated that patients with PCOS undergoing IVF-ICSI have a similar ongoing pregnancy and miscarriage rates compared with patients without PCOS (12,13). Moreover, Sunkara et al (14) demonstrated that the number of oocytes obtained at retrieval is highly correlated to live-birth rates in fresh IVF cycles, and that the optimal number to maximize the live-birth rate is 15.0, similar to the average number of oocytes (15.7) obtained in the patients in this study who experienced a premature LH rise (14).…”

Predictors of Insulin Resistance and Metabolic Complications in Polycystic Ovarian Syndrome in an Eastern Indian Population

“…Insulin resistance and hyperinsulinemia are closely linked to androgenic abnormalities found in this disease [5] that significantly predispose them to several metabolic and cardiovascular complications. Although, numerous studies have linked PCOS to obesity, type 2 diabetes mellitus (DM), dyslipidemia, hypertension, and heart disease [6][7][8], significant differences existed between them. As much as 64 % of PCOS patients were found to have insulin resistance that could not be predicted by weight alone [9].…”

Useeffect of Body Mass Index on in Vitro Fertilization/Intra-Cytoplasmic Sperm Injection Outcome in Egyptian Women with Polycystic Ovary Syndrome

“…Moreover, their results are controversial, as Beydoun and colleagues reported no significant effect of BMI and outcome measures of infertility treatment success 20 . On the contrary, Orievto et al obtained a significantly higher CPR in PCOS patients with BMI ≤ 25kg/m² compared to those with BMI > 25kg/m² 15,21 .…”