Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study

Fearnley, Emily; Marquart, Louise; Spurdle, Amanda B.; Weinstein, Philip; Webb, Penelope M.

doi:10.1007/s10552-010-9658-7

Cited by 141 publications

(85 citation statements)

References 26 publications

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“…Cases were women aged 18-79 years diagnosed with primary epithelial endometrial cancer between May 2005 and December 2007. 19 Approximately 55% of eligible Queensland women participated in the study. A family history questionnaire was provided to women at recruitment to record the age or age at death and any cancer diagnoses (site and age at diagnosis) among their first, second and relevant at-risk third-degree relatives.…”

Section: Study Participants and Methodsmentioning

confidence: 99%

Improving identification of lynch syndrome patients: A comparison of research data with clinical records

Tan

McGaughran

Ferguson

et al. 2013

Intl Journal of Cancer

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Current evidence suggests poor identification and referral of Lynch syndrome patients. This study evaluated the strategies by which patients with endometrial cancer were referred to genetics services. Data from clinic-based patients with endometrial cancer enrolled through the Australian National Endometrial Cancer population-based research study with detailed family history information were analyzed. The Amsterdam II criteria, the revised Bethesda guidelines, and criteria adapted for this study was assessed using personal/family history information. The percentages of patients referred and who could have been referred to genetics services, and the performance of each criterion for identifying possible mismatch-repair (MMR) gene mutation carriers, based on tumor MMR immunohistochemistry (IHC), were determined. Research data indicated that 236/397(59%) of patients with endometrial cancer had family/personal history of cancer, including 14 (4%) who fulfilled Amsterdam II criteria. Family history information was noted in the hospital records for only 61(15%) patients, including 7/14 (50%) of patients meeting Amsterdam criteria, and always less extensively than that recorded in the research setting. Only 13 patients (two meeting Amsterdam criteria) were referred for genetic assessment. Of 58 patients with tumor MMR protein-IHC loss, the Amsterdam criteria and Bethesda guidelines identified only three and 34% of these possible germline mutation carriers, respectively. Greater sensitivity (60%) was obtained using a single criterion proposed by our study, 2 first-degree or second-degree relatives reporting Lynch cancers. Hospital records indicate poor recognition of family history. Application of research methods show improved identification and may facilitate appropriate referrals of endometrial cancer patients with possible Lynch syndrome.

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Section: Study Participants and Methodsmentioning

confidence: 99%

Improving identification of lynch syndrome patients: A comparison of research data with clinical records

Tan

McGaughran

Ferguson

et al. 2013

Intl Journal of Cancer

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“…A pesar de que la obesidad no ha sido considerada un criterio diagnóstico de SOP, esta se presenta en alrededor del 30% de las pacientes en edad reproductiva con SOP, y se ha reportado que un porcentaje importante de mujeres en edad reproductiva con SOP, aunado a las alteraciones hormonales propias del SOP, presentan alteraciones metabolicas 2 . De la misma manera, en pacientes con SOP se ha reportado un incremento del riesgo cardio-metabolico 3 , y el SOP ha sido considerado un factor de riesgo importante de desarrollo de cáncer endometrial 4 .…”

Section: Introductionunclassified

Alteraciones metabólicas sutiles en adolescentes con obesidad y síndrome de ovario poliquístico

Vital-Reyes

López-Alarcón

Inda-Icaza

et al. 2019

GMM

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“…Важно, что СПКЯ показан как независимый фак-тор риска рака эндометрия (РЭ), к тому же высокая частота ожирения и малоподвижный образ жизни у данной категории женщин ещё сильнее увеличивают риск РЭ [10]. Риск развития РЭ у женщин с СПКЯ в 3-5 раз выше и занимает у данной группы пациенток первое место в структуре всех гинекологических злокачественных новообразований [35].…”

Section: Polycystic Ovary Syndrome (Pcos) Is the Most Common Endocrinunclassified

“…Отмечены различия в фенотипе женщин с РЭ при наличии и без СПКЯ. Во-первых, средний возраст постановки диагноза РЭ у женщин без СПКЯ состав-ляет около 70 лет, тогда как у пациенток с СПКЯ РЭ возникает уже в возрасте младше 50 лет [10,13]. Это может быть объяснено присутствием гормональных и метаболических нарушений в данной группе уже с молодого возраста.…”

Section: Polycystic Ovary Syndrome (Pcos) Is the Most Common Endocrinunclassified

Endometrial Markers of Polycystic Ovary Syndrome (A Literature Review)

Sharifulin¹,

Шарифулин²,

Сутурина³

2018

Acta Biomedica Scientifica

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Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women and has a significant impact on various aspects of their health and the quality of life. The epidemiology of PCOS is well understood, while the prevalence of this syndrome depends on diagnostic criteria used, the characteristics of the population sample, and vary from 6-10 % to 15 % and higher. A number of studies suggest that the endometrium in women with PCOS differs from the normal endometrium morphologically and functionally. PCOS is associated with infertility problems, higher incidence of pregnancy complications and with increased risk of endometrial cancer, especially when obesity is present.

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Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case–control study

Abstract: These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.

Cited by 141 publications

References 26 publications

Improving identification of lynch syndrome patients: A comparison of research data with clinical records

Improving identification of lynch syndrome patients: A comparison of research data with clinical records

Alteraciones metabólicas sutiles en adolescentes con obesidad y síndrome de ovario poliquístico

Endometrial Markers of Polycystic Ovary Syndrome (A Literature Review)

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