2016
DOI: 10.7861/clinmedicine.16-3-262
|View full text |Cite
|
Sign up to set email alerts
|

Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance

Abstract: Polycystic ovary syndrome (PCOS) is a common condition that typically develops in reproductive-age women. The cardinal clinical and biochemical characteristics of PCOS include reproductive dysfunction and hyperandrogenic features. PCOS is also strongly associated with obesity based on data from epidemiological and genetic studies. Accordingly, PCOS often becomes manifest in those women who carry a genetic predisposition to its development, and who also gain weight. The role of weight gain and obesity in the de… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
41
0
4

Year Published

2017
2017
2023
2023

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 87 publications
(51 citation statements)
references
References 30 publications
1
41
0
4
Order By: Relevance
“…Intralipid administration elevates circulating FFA levels that have deleterious effects in humans, promotes proinflammatory cytokine TNFα secretion, interferes with glucose metabolism, obstructs glucose oxidation and reduces glucose disposal rate . As a consequence, this promotes hepatic and peripheral IR More than 50% of women with PCOS have lower IS and higher IR compared with healthy women. The metabolic pathways responsible for this contrasting IR profile are not completely understood.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Intralipid administration elevates circulating FFA levels that have deleterious effects in humans, promotes proinflammatory cytokine TNFα secretion, interferes with glucose metabolism, obstructs glucose oxidation and reduces glucose disposal rate . As a consequence, this promotes hepatic and peripheral IR More than 50% of women with PCOS have lower IS and higher IR compared with healthy women. The metabolic pathways responsible for this contrasting IR profile are not completely understood.…”
Section: Discussionsupporting
confidence: 92%
“…3 PCOS women have elevated levels of cardiovascular disease risk (CVD) factors including type 2 diabetes (T2DM), carotid intima-media wall thickness and platelet dysfunction. 4 Weight loss improves many clinical features of PCOS, including menses regularity and fertility, 5 and reduces CVD risk factors and IR 6 Cellular mechanisms leading to IR in PCOS are not clearly understood. Adipose tissue dysfunction and dysregulated expression of adipokines have been implicated in the pathophysiology of PCOS.…”
Section: Introductionmentioning
confidence: 99%
“…Se ha reportado que el hiperandrogenismo clínico o bioquí-mico se observa en alrededor del 70% de las pacientes, mientras que el 27% presenta disfunción ovulatoria y en alrededor del 20% de las pacientes con SOP se documenta la presencia de ovarios de aspecto poliquístico por ultrasonografía acorde con los criterios vigentes, y la prevalencia de resistencia a la insulina (RI) es variable 5 . La interacción del exceso de andrógenos, el alto índice de masa corporal (IMC) y la RI en pacientes con SOP forma parte de la fisiopatología de este sín-drome.…”
Section: Introductionunclassified
“…Epidemiological studies support the relationship between obesity and PCOS, further evidenced by observations that modest weight loss can reduce the manifestations of the disease . Insulin resistance appears to be an important contributor to the pathogenesis of PCOS, mediating androgen secretion . Insulin resistant states other than those observed in obese individuals are associated with ovarian dysfunction that bears many of the hallmarks of PCOS .…”
Section: Clinical Features Of Irmentioning
confidence: 99%