Polycystic ovary syndrome (PCOS) and oxidative stress

Sengupta, Pallav; Dutta, Sulagna; Fallah Hassan, Muhjah

doi:10.62110/sciencein.jist.2024.v12.752

Cited by 11 publications

(2 citation statements)

References 94 publications

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“…In reality, PCOS is linked to reproduction, metabolic, psychological dysfunction, and clinical complications examples include reduced tolerance for glucose and diabetes, hypertension, severe cardiovascular disease, chronic oligo-ovulation, infertility, anovulation, and ovarian cancer. Despite a lengthy history of research on PCOS, the aetiology is yet unclear, but have revealed involvement in an inflammatory state, endothelial injury, oxidative stress [OS], in addition genetic pathways [4,5]. markers are much greater in women with PCOS than in the general population, and they are now recognized as a possible cause of PCOS aetiology.…”

Section: Introductionmentioning

confidence: 99%

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

Rashed,

Al-Abachi,

Hamoo

2025

Egyptian Journal of Veterinary Sciences

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H UMAN and animal anovulation is a result of polysystolic ovary PCOS which involves endocrine, reproductive, and metabolic abnormalities. Finding new medications with least amount of toxicity is a major scientific challenge. The study's goal is to assess biochemical variables in blood serum and heart tissue in female rats as models with androgen-induced PCOS and the impact of oxidative stress in development of cardiovascular characteristics resulting from PCOS. PCOS-induced rats were treated with liquorice root [L.], green tea [GT], and marjoram [M.] extracts at 150, 250 and 100 mg Kg −1 B.W. respectively. Metformin [Met.] 20 mg kg −1 B.W. used as a standard medication. The study employed 36 female rats aged 8-10 weeks. Six [n=6] groups of rats were formed. At zero time and at the end of the trial, blood was obtained from all rats to estimate total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, glucose, total protein, CRP, glutathione, malondialdehyde, glutathione peroxidase, AST, ALT, ALP, testosterone, estradiol, progesterone in blood and CK, LDH, IL-1β and TNF-α in heart tissue. In female rats treated with androgen, there has been a rise in all measured parameters except HDL-C, estradiol, progesterone, GSH, GSH-Px and, which increased again in three extracts-treated groups. M. extract was more active than GT and L. extracts in improvement of cardiovascular [CV] parameters. Since CK, LDH and IL-1β were regained normal values. In conclusion, study demonstrated that M., GT, and L. can decrease the negative effects of PCOS in particular on cardiovascular features, and treating PCOS with these herbs is recommended.

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Section: Introductionmentioning

confidence: 99%

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

Rashed,

Al-Abachi,

Hamoo

2025

Egyptian Journal of Veterinary Sciences

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“…Due to their unstable and highly reactive nature, peroxides and free radicals have the potential to damage various cellular components, with DNA damage having particularly concerning long-term consequences. (Sengupta et al , 2024 ;Darbandi et al , 2018 ;Alahmar and Sengupta , 2021 ) . OS is believed to be a potential triggering factor in the pathophysiology of PCOS.…”

Section: Introductionmentioning

confidence: 99%

A case-control study unravelling the prognostic significance of oxidative markers in polycystic ovary syndrome (PCOS) patients

Mishra,

Samant,

Patil

2024

JANS

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Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders in female. Reproductive organ is a metabolically active organ; hence reactive oxygen species (ROS) are inevitably generated during the physiological process. Studies have suggested that OS may affect female fertility by reproductive impairment, leading to alter ovulation patterns, oocyte maturation and steroidogenesis in women with PCOS. Thus, the present study aimed to assess the oxidative status of diagnosed PCOS women. Based on specific inclusion and exclusion criteria, 100 Subjects (Group – 1 PCOS N=50 , Group-2 Controls N=50) were enrolled with their written informed consent. Blood samples were collected in aseptic conditions for the estimation of hormonal parameters (Testosterone) and oxidative stress markers (MDA, SOD, Catalase, GSH, GSSG). The statistical analysis of data indicated significant elevated level of MDA, SOD, GSSG (5.21 vs 1.52 ; 248.15 vs166.15; 11.38 vs 4.37), while decreased level of catalase and GSH (37.57 vs 78.2; 84.09 vs 121.7) was observed in PCOS cases when compared to controls. The linear regression model showed significant R2 values for MDA, SOD and GSSG . Further ROC curve was plotted for MDA, SOD and GSSG to estimate the sensitivity of these predictive markers. OS damages oocyte and follicle growth in females, damaging the endometrium and affecting endocrine function. Significantly higher levels of MDA, SOD & GSSG were reported in cases, and catalase, GSH levels were decreased. Linear regression and ROC curve analysis indicated that these MDA, SOD, GSSG may act as significant predictive markers of OS playing a pivotal role in the pathophysiology underlying PCOS and as prognostic tools to reduce the severity of the disease.

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Design, Synthesis and Biological Evaluation of Novel 6‐Amino‐3‐phenyl‐2H‐chromen‐2‐one Derivatives for Polycystic Ovary Syndrome Management

Khan,

Suhagia,

Prajapati

et al. 2024

ChemistrySelect

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Polycystic Ovary Syndrome (PCOS) is a widespread and complex hormonal disorder occurs in women of reproductive age, characterized by hormonal imbalances and ovarian dysfunction. Current approaches to treating PCOS often address specific symptoms, highlighting the demand for innovative therapeutic agents that can tackle its multifaceted nature. The present study endeavors to investigate the potential of new chromen‐2‐one derivatives in the management of PCOS. A total of 30 derivatives have been synthesized and evaluated for their in vitro inhibitory effects on 5‐α reductase and antioxidant activities. Based on the promising in vitro activity and acute toxicity profile of 4‐methoxy‐N‐(3‐(4‐methoxyphenyl)‐2‐oxo‐2H‐chromen‐6‐yl) benzamide (29), it was selected for subsequent in vivo investigation in experimental animal models of PCOS. The study also includes molecular interaction analysis through docking and dynamic studies of compound (29).

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Polycystic ovary syndrome (PCOS) and oxidative stress

Cited by 11 publications

References 94 publications

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

The Role of Oxidative Stress on Cardiovascular Properties of the Androgen- Induced PCOS in Female Rats

A case-control study unravelling the prognostic significance of oxidative markers in polycystic ovary syndrome (PCOS) patients

Design, Synthesis and Biological Evaluation of Novel 6‐Amino‐3‐phenyl‐2H‐chromen‐2‐one Derivatives for Polycystic Ovary Syndrome Management

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