Polycystic ovary syndrome

Chen, Zi‐Jiang; Shi, Yuhua

doi:10.1007/s11684-010-0098-2

Cited by 18 publications

(11 citation statements)

References 33 publications

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“…Current thought on the etiologies that lead to development of PCOS is that there are both genetic and environmental causal factors. A genetic predisposition in an individual may combine with an early-life environmental impact such as fetal stress or increased androgens in utero and lead to development of PCOS in adulthood [44], [45], [46]. Fetal or early postnatal exposure to androgens (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the rodent PCO model has many of the same clinical correlations that are seen with PCOS in humans. Sequence variations in several genes have been associated with PCOS [46], [50], [51], although at very low frequency and none are highly predictive. Epigenetic abnormalities such as those associated with non-random X-chromosome inactivation have also been linked to PCOS [51], [52], [53], [54].…”

Section: Introductionmentioning

confidence: 99%

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Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Nilsson¹,

Larsen²,

Manikkam³

et al. 2012

PLoS ONE

228

230

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The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adult onset ovarian disease was assessed. Transgenerational disease phenotypes observed included an increase in cysts resembling human polycystic ovarian disease (PCO) and a decrease in the ovarian primordial follicle pool size resembling primary ovarian insufficiency (POI). The F3 generation granulosa cells were isolated and found to have a transgenerational effect on the transcriptome and epigenome (differential DNA methylation). Epigenetic biomarkers for environmental exposure and associated gene networks were identified. Epigenetic transgenerational inheritance of ovarian disease states was induced by all the different classes of environmental compounds, suggesting a role of environmental epigenetics in ovarian disease etiology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Nilsson¹,

Larsen²,

Manikkam³

et al. 2012

PLoS ONE

228

230

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“…Several lines of evidence have indicated that these insulin-resistant conditions are involved in the pathogenesis of PIH [5][6][7]. In addition, the incidence of abortion is higher in pregnant women with PCOS than in those without complications [8,9].…”

mentioning

confidence: 99%

Improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by insulin-like growth factor-I

et al. 2013

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Insulin-like growth factor-I (IGF-I) has been shown to stimulate extravillous trophoblast (EVT) cell migration and invasion, and to play a crucial role in placental function, thereby, influencing placental development and fetal growth. Insufficient invasion of EVT cells into the uterine endometrium leads to pregnancy-related complications, including spontaneous abortion, fetal growth restriction (FGR), and pregnancy-induced hypertension (PIH). Insulin-resistant conditions such as polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) have also been associated with abortion and PIH. However, the effects of IGF-I on EVT cells under insulin-resistant conditions have not been elucidated yet. The current study was undertaken to analyze the effects of IGF-I under insulin-resistant conditions and to determine whether improvement in insulin sensitivity alters IGF signaling and cell migration in the EVT. Incubation with pioglitazone, an insulin sensitizer, increased peroxisome proliferator-activated receptor-γ (PPARγ) expression after 48 h. A 48-h pre-incubation with insulin reduced the phosphorylation and concentration of the insulin receptors, which were increased by insulin treatment. Long-term exposure to insulin reduced phosphorylation of the IGF-I receptor, insulin receptor substrate-1 (IRS-1), and Akt, and also reduced EVT cell migration. However, when the cells were incubated with pioglitazone in addition to insulin for 48 h, the phosphorylation of these proteins was restored. This combination partially reversed the inhibitory effect of insulin on EVT cell migration. These results suggest that abnormalities in pregnancy that are induced by loss of insulin sensitivity can be treated by improving insulin sensitivity.

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“…It is a heterogeneous disease characterized by oligo-ovulation and/or anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries on ultrasound [2]. Women with PCOS have a high risk suffering from metabolic syndrome [3], type 2 diabetes (T2D) and cardiovascular diseases [4], [5]. Insulin resistance, present in perhaps 70% of women with PCOS [6], [7], may play an important role in the long-term complications of PCOS.…”

Section: Introductionmentioning

confidence: 99%

Association Study of Gene LPP in Women with Polycystic Ovary Syndrome

Zhang

Zhao

et al. 2012

PLoS ONE

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BackgroundPrevious genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS.MethodsThree polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method.ResultsIn rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (Pmeta = 1.89E-05, OR = 1.23), rs4449306 (Pmeta = 3.0E-04, OR = 1.10), rs6782041 (Pmeta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls.ConclusionsOur results suggest that LPP gene might be a novel candidate for PCOS.

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Polycystic ovary syndrome

Cited by 18 publications

References 33 publications

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by insulin-like growth factor-I

Association Study of Gene LPP in Women with Polycystic Ovary Syndrome

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