Polycythemia in dogs with chronic hypoxic pulmonary disease

Abstract

Background: Prolonged tissue hypoxia caused by chronic pulmonary disease is commonly regarded as an important mechanism in the development of secondary polycythemia, but little clinical data are available to support this hypothesis.Objective: To study the prevalence and severity of erythrocytosis accompanying chronic hypoxic pulmonary disease in dogs.Animals: Forty-seven dogs with hypoxic chronic pulmonary disease, 27 dogs with nonhypoxic chronic pulmonary disease, and 60 healthy controls.Methods: Dogs with chronic pulmonary disease and chronic hypoxemia (partial pressure of arterial oxygen [PaO 2 ] < 80 mm Hg on at least 2 arterial blood gas measurements a minimum of 1 month apart) were identified retrospectively from patient records. Association between arterial oxygen and red blood cell parameters was analyzed using Pearson's correlation coefficients and multivariable linear regression analysis.Results: Red blood cell parameters measured at the end of the hypoxemia period were within the laboratory reference range in most dogs. In chronically hypoxemic dogs, hematocrit (Hct) was increased in 4/47 (8.5%; 95% confidence interval [CI], 0-17) dogs, erythrocyte count (Erytr) was increased in 12/47 (26%; 95%CI, dogs and hemoglobin concentration (Hb) was increased in 3/47 (6.4%; 95%CI, 0-14) dogs. No marked polycythemia (Hct ≥65%) was noted in any of the dogs. Red blood cell parameters were not associated with the severity of hypoxemia (correlation to

Relationship between Respiratory Rate, Oxygen Saturation, and Blood Test Results in Dogs with Chronic or Acute Respiratory Disease: A Retrospective Study

“…In dogs, prolonged tissue hypoxia caused by chronic lung disease is generally considered an important mechanism for the development of secondary polycythemia [ 29 ]. Although several studies have investigated the prevalence of polycythemia in dogs with chronic hypoxemia, its occurrence is rare [ 30 , 31 ]. In this study, no apparent increase in erythrocytes was observed in the lung disease group, suggesting that a pathology different from that in humans was involved.…”

A Subchronic Toxicity Test of Dillenia ochreata Leaves Extract on Wistar rats

“…This indicates that the ethanol extract of D. ochreata leaves did not affect polycythaemia in the test animals. 23 All treatment groups showed normal leukocyte values, except for the female group, 800 mg/kg BW, with leukocyte values above the normal range (Table 3). Analysis of leukocyte levels in female rats at a dose of 800 mg/ kg BW significantly differed ( p<0.05) from the control group.…”