Polycythemia vera terminating in chronic neutrophilic leukemia: Report of a case

Progression of myeloproliferative neoplasms to myelofibrosis and acute leukaemia

“…The presentation resembled CML, but no bcr-abl rearrangement was detectable, whereas 85% of JAK2 V617F alleles were present. Similar cases have been described by others [16][17][18][19]. Besides bcr-abl-negative CML, transitions with Philadelphia chromosome positivity have been reported [20][21][22][23].…”

Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia case report

“…Contrary to our findings, several reports have suggested that the neoplastic origin of CNL appears to be pluripotent progenitors, based on (1)(q21), del(6)(p23), add(7) (q22), add(7)(q32), del(11)(q21), del (12)(p13). observations of CNL in patients with polycythemia vera [14,15] and abnormal platelet functions in patients with CNL [5,16]. However, there have been no reports focusing on the hematopoietic progenitors and providing direct evidence of the neoplastic origin of CNL.…”

Elevated neutrophil function in chronic neutrophilic leukemia

“…These different results for CNL neutrophil functions may be due to differences in the pathophysiology of each case or to technical problems in the assessment of neutrophil functions. The etiology of CNL is not well known, but it appears that CNL is a clonal hemopathy, since a few cases showed chromosomal abnormalities [4,21] and a few other cases [22,23] were accompanied by polycythemia Vera, which is thought to indicate oncogenesis at the stage of multipotential stem cells, as shown by G6PD isozyme analysis [35]. Examination of X-chromosomal RFLPs [36] may clearly document the clonality of the leukemic cells in this patient.…”