Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants

Koneru, Meghana; Sahu, Bidya Dhar; Gudem, Sagarika; Kuncha, Madhusudana; Ravuri, Halley Gora; Kumar, Jerald Mahesh; Kilari, Eswar Kumar; Sistla, Ramakrishna

doi:10.1016/j.phymed.2017.01.013

Cited by 40 publications

(24 citation statements)

References 26 publications

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“…To date, PD has caught great attention for its remarkable curative effect on both D-galactose- [ 18 ] and CCl 4 - [ 15 ] induced liver injury. Besides, PD has also been found to have a benefit in alleviating ethanol-induced liver damage by refurbishing the matrix metalloproteinases levels and attenuating oxidative stress in mice [ 19 ]. In our experiments, we provide additional evidence that PD pretreatment was able to exert protective effect against ethanol-induced hepatotoxicity by elevating antioxidant capacity, preventing inflammatory response and the relevant signaling pathways, and ameliorating the steatosis of liver cells.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous study, we found that PD attenuates D-galactose-induced liver injury [ 18 ]. Besides, PD has protective effect on CCl 4 -induced liver injury [ 15 ] and ethanol-induced liver injury in mice [ 19 ]. What is more, emerging evidence has demonstrated that resveratrol mitigates ethanol-induced oxidative stress in the liver of rats [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Polydatin Protects Rat Liver against Ethanol‐Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF‐κB p65 Pathway

Huang

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Excessive alcohol consumption leads to serious liver injury, associating with oxidative stress and inflammatory response. Previous study has demonstrated that polydatin (PD) exerted antioxidant and anti-inflammatory effects and attenuated ethanol-induced liver damage, but the research remained insufficient. Hence, this experiment aimed to evaluate the hepatoprotective effect and potential mechanisms of PD on ethanol-induced hepatotoxicity. Our results showed that PD pretreatment dramatically decreased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the serum, suppressed the malonaldehyde (MDA) and triglyceride (TG) content and the production of reactive oxygen species (ROS), and enhanced the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), andalcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH), paralleled by an improvement of histopathology alterations. The protective effect of PD against oxidative stress was probably associated with downregulation of cytochrome P450 2E1 (CYP2E1) and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its target gene haem oxygenase-1 (HO-1). Moreover, PD inhibited the release of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) via downregulating toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) p65. To conclude, PD pretreatment protects against ethanol-induced liver injury via suppressing oxidative stress and inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polydatin Protects Rat Liver against Ethanol‐Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF‐κB p65 Pathway

Huang

Liu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…The homogenized suspension was centrifuged at 3000× g for 20 min at 4 °C, and the supernatant was used to measure the enzyme activity. CAT, SOD, GR, and GST were considered as oxidative stress markers [ 5 ] and measured as follows: SOD activity was analyzed using the McCord & Fridovich method [ 22 ]; and CAT activity was determined using the protocol by Aebi [ 23 ]; GST and GR activity was measured using a protocol by Koneru et al [ 24 ]. The amount of protein was quantified using bicinchoninic acid (BCA) to measure the enzyme activity.…”

Section: Methodsmentioning

confidence: 99%

Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats

Eom

Kim

et al. 2020

Antioxidants

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This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and phenolic compounds in the former. We found that the main phenolic acid was chlorogenic acid and the major flavonoid was rutin. Results from the animal model experiment showed concentration-dependent liver protection with the distilled water extract showing better liver protection than the ethanol extract. Gut microbiota dysbiosis induced by alcohol consumption was significantly shifted by DML extracts through increasing mainly Bacteroides and Allobaculum. Moreover, predicted metabolic activities of biosynthesis of beneficial monounsaturated fatty acids such as oleate and palmitoleate were enhanced. Our results suggest that these hepatoprotective effects are likely due to the increased activities of antioxidant enzymes and partially promoted by intestinal microbiota shifts.

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“…The oral administration of 50 or 100 mg/kg polydatin daily for 8 d alleviates the alcohol-induced hepatic injury by reducing the liver injury markers, ALT and AST, attenuating OS, and restoring the antioxidant balance in the hepatic tissue. Polydatin pre-treatment prevents alcohol-induced mitochondrial damage and refurbishes the MMP levels in the liver [122]. Hence, polydatin may have a potential benefit in preventing alcohol-induced acute hepatic injury.…”

Section: Other Compoundsmentioning

confidence: 99%

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

et al. 2018

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Liver fibrosis is a wound-healing response characterized by the accumulation of extracellular matrix following various liver injuries, which results in the deformation of the normal liver architecture and the development of liver cirrhosis and even hepatocellular carcinoma. Numerous in vitro and in vivo studies indicated that oxidative stress mediates the initiation and progression of liver fibrosis. Overaccumulation of reactive oxygen species disrupts macromolecules, induces necrosis and apoptosis of hepatocytes, stimulates the production of pro-fibrogenic mediators, and directly activates hepatic stellate cells, thereby resulting in liver damage and initiating liver fibrosis. Ameliorating oxidative stress is a potential therapeutic strategy for the treatment of liver fibrosis. Natural antioxidants have attracted increasing attention in treating liver fibrosis due to their safety and efficacy. In this review, the pathogenesis of liver fibrosis and the role of oxidative stress in liver fibrosis were discussed. Naturally occurring antioxidants that can treat and prevent liver fibrosis were summarized. Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of oxidative stress in liver fibrosis to representative antioxidants for treating liver fibrosis. Naturally occurring antioxidants show a potential for further investigations as lead compounds in fighting liver fibrosis.

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Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants

Cited by 40 publications

References 26 publications

Polydatin Protects Rat Liver against Ethanol‐Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF‐κB p65 Pathway

Polydatin Protects Rat Liver against Ethanol‐Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF‐κB p65 Pathway

Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats

Fighting Liver Fibrosis with Naturally Occurring Antioxidants

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