Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

Huang, Kaipeng; Chen, Cheng; Hao, Jie; Huang, Junying; Wang, Shaogui; Liu, Peiqing; Huang, Heqing

doi:10.1016/j.mce.2014.08.014

Cited by 177 publications

(98 citation statements)

References 37 publications

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“…Kawai et al (7) demonstrated that SIRT1-mediated deacetylation of the NRF2 protein terminated the transcription of antioxidant genes in vitro. However, other studies have demonstrated that SIRT1 overexpression significantly promoted the nuclear accumulation, DNA binding and transcriptional activity of NRF2 and NRF2-mediated gene expression (8,9,23). In the current study, an increase in the SIRT1 expression levels by Res was associated with a high level of NRF2.…”

Section: Discussionmentioning

confidence: 92%

“…Previous studies have demonstrated that the SIRT1-mediated deacetylation of NRF2 terminated the transcription of antioxidant genes (7). By contrast, SIRT1 is known to protect cells from oxidative stress injury, and silencing its activity results in decreased NRF2 expression levels (8,9). However, the association between SIRT1 and NRF2 and their effect in PQ-induced oxidative stress remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Zhao

Chen

et al. 2015

Molecular Medicine Reports

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Abstract. Sirtuin 1 (SIRT1) acts via the deacetylation of a number of crucial transcription factors and has been implicated in various biological processes, including oxidative stress. Previous studies have indicated that nuclear factor, erythroid 2-like 2 (NRF2) is an effective target of antioxidant therapy for paraquat (PQ) poisoning. However, the association between SIRT1 and NRF2 and their effects in PQ-induced oxidative stress remains to be elucidated. The current study demonstrated that PQ exposure upregulated the expression of SIRT1 and NRF2 following 6-and 24-h exposure in the lungs of mice. However, long-term exposure to PQ significantly decreased the expression of SIRT1 and NRF2. Resveratrol is a SIRT1 activator, and strongly enhanced SIRT1 expression and attenuated the lung injury resulting from PQ exposure in the current study. Additionally, treatment with resveratrol upregulated the expression of NRF2 and glutathione, increased the activity of heme oxygenase-1, superoxide dismutase and catalase, but depleted the expression of malondialdehyde. The present results demonstrated that resveratrol reduced PQ-induced oxidative stress and lung injury, potentially through the positive feedback signaling loop between SIRT1 and NRF2.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Zhao

Chen

et al. 2015

Molecular Medicine Reports

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“…Furthermore, activation of SIRT1 is known to promote the nuclear factor-E2 related factor 2- (Nrf2-) antioxidant response element (ARE) pathway [37]. Here, we determined that the antioxidant activity of pomegraniin A occurs through activation of the SIRT3 - SOD2 pathway.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate‐Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3‐Mediated SOD2 Activation

Zhao

Sakaguchi

Fujita

et al. 2016

Oxidative Medicine and Cellular Longevity

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Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-augmenting pomegranate-derived polyphenols (eucalbanin B, pomegraniin A, and eucarpanin T1). Among them, pomegraniin A activated superoxide dismutase 2 (SOD2) through SIRT3-mediated deacetylation, thereby reducing intracellular reactive oxygen species. The other SIRT3-augmenting polyphenols tested also activated SOD2, suggesting antioxidant activity. Our findings clarify the underlying mechanisms involved in the antioxidant activity of pomegraniin A.

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“…For example, increase of dSir2 transcription is observed in the long-lived mutant flies and calorierestricted normal flies [60]. It was found, that pharmacological agents resveratrol [61], polydatin [62], syringaresinol [63], and phloridzin [64], which are known to have anti-aging effect and relive senescence-associated patologies, induces expression of the SIRT1 homologues too.…”

Section: Discussionmentioning

confidence: 99%

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Lashmanova

Proshkina

Zhikrivetskaya

et al. 2015

Pharmacological Research

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Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

Cited by 177 publications

References 37 publications

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

Pomegranate‐Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3‐Mediated SOD2 Activation

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

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