Polydextrose Enhances Calcium Absorption and Bone Retention in Ovariectomized Rats

Abstract

Purpose. To evaluate the effect of polydextrose (PDX) on Ca bioavailability and prevention of loss of bone mass. Methods. Twenty-four two-month-old ovariectomized rats were fed three isocaloric diets only varied in fiber source and content up to 60 days (FOS group, a commercial mixture of short- and long-chain fructooligosaccharide, OVX group fed AIN 93 diet, and PDX group). A SHAM group was included as control. Apparent Ca absorption percentage (%ABS), changes in total skeleton bone mineral content (tsBMC) and bone mineral density (BMD) and femur BMD, % Bone Volume, Ca and organic femur content, caecal weight, and pH were evaluated. Results. %ABS and caecum weight of PDX and FOS were higher, and caecum pH was lower compared to OVX and SHAM. PDX reached a higher pH and lower caecum weight than FOS possibly because PDX is not completely fermented in the colon. Changes in tsBMC and femur BMD in FOS and PDX were significant lower than SHAM but significantly higher than OVX. % Bone Volume and femur % of Ca in PDX were significantly higher than OVX and FOS but lower than SHAM. Conclusions. PDX increased Ca absorption and prevented bone loss in OVX rats.

Effects of the intake of white wheat bread added with garlic and resistant starch: action on calcium bioavailability and metabolic parameters of growing Wistar rats

“…According to Cashman and other authors (2003), 32 the decrease of pH promotes the growth of beneficial bacteria, such as Bifidobacterium and Lactobacillus and improves the absorption of some minerals like Ca, maintaining it in solution. 17,33,34 The decrease in the cecal pH of the BGR group is consistent with an increase in the absorption of Ca with respect to the B group ( p < 0.001). Table 5 presents the values for the total skeleton bone mineral content (ts BMC) and the bone mineral density of total body (ts BMD), femur (F-BMD), spine (S-BMD), and proximal tibia (T-BMD) at the end of the experiment (t = 60), in the three experimental groups.…”

“…At the end of the experiment (t = 60), total skeleton bone mineral content (ts BMC) and total skeleton bone mineral density (ts BMD) were determined in vivo under light anesthesia with a total body scanner by dual energy X-ray absorptiometry (DXA), provided with specifically designed software for small animals (DPX Alpha, Small Animal Software, Lunar Radiation Corp., Madison, WI) as previously described. [17][18][19] In brief, all rats were scanned using an identical scan procedure. Precision was assessed by measuring one rat five times with repositioning between scans on the same day and on different days.…”

Short-term supplementation with dietary fructooligosaccharide and dietary mannitol elevated the absorption of calcium and magnesium in adult rats

“…The fermentation of these short chain carbohydrates contributes to the absorption of bone-relevant minerals such as calcium and magnesium and improves bone mineral content (Weaver et al 2011;Weisstaub et al 2013). Ca retention was increased after day 11 of the supplementation of indigestible oligosaccharides, but this beneficial effect did not continue after day 25 in rats (Ohta et al 1994).…”

Calcium–inulin wheat bread: prebiotic effect and bone mineralisation in growing rats

“…The length and weight of fat‐free and dried femurs were determined. Femur ash was obtained at 700 °C and then dissolved in HCl and diluted for Ca and P analysis (Weisstaub et al ., ).…”