Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy

Abstract

We report a design and fabricate multifunctional localized platform for cancer therapy. Multiple stimuli-responsive polydopamine (PDA) was used for surface modification of electrospun doxorubicin hydrochloride (DOX) loaded polycaprolactone (PCL) fibers to make a designated platform. Photothermal properties such as photothermal performance and stability of the resulting composite mats were studied under the irradiation of the near-infrared (NIR) laser of 808 nm. With the incorporation of PDA into the fiber, a remarkable increase of local temperature was recorded under NIR illumination in a concentration-dependent manner with excellent stability. Drug released assay results revealed PDA coated PCL-DOX mats showed pH and NIR dual responsive behavior thereby exhibiting improved drug release in an acidic medium compared to physiological pH condition (pH 7.4) which is further increased by NIR exposure. The cancer activity in vitro of the mats was evaluated using cell counting (CCK) and live and dead cell assays. The combined effect of NIR mediated hyperthermia and chemo release resulting improved cells death has been reported. In summary, this study presents a major step forward towards a therapeutic model to cancer treatment utilizing pH and NIR dual responsive property from PDA alone in a fibrous mat.

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

“…Electrospinning is a method for the facile fabrication of nanofibers under the influence of an external electric field. It allows the fabrication of continuous fibers with nano-to microscale diameters [71][72][73]. In 1887, C. V. Boys showed that fibers could be produced from a viscoelastic liquid in the presence of an external electric field [74].…”

Magnetic Silica Nanosystems With NIR-Responsive and Redox Reaction Capacity for Drug Delivery and Tumor Therapy

“…Many studies have shown that PDA with good biocompatibility and adhesion can effectively absorb NIR lasers (Maziukiewicz et al, 2019;Tiwari et al, 2019) and efficiently transform light into heat (Liu et al, 2014;Lin et al, 2018;Chen et al, 2019). Therefore, we studied the light absorption behavior of FMPBs to determine their photothermal conversion ability for PTT of tumors (Maziukiewicz et al, 2019).…”

“…Many nanomaterials with an appropriate size and photothermal conversion ability are used for tumor treatment (Huo et al, 2017;Wang et al, 2019Wang et al, , 2020. During PTT, tumor cells are killed by the heat of photothermal nanoparticles after being irradiated with near-infrared (NIR) laser (Li et al, 2018;Lin et al, 2018;Tiwari et al, 2019). PTT involves the use of photothermal materials that can effectively convert light radiation into heat to cure cancer via hyperthermia (Feng et al, 2018a).…”

NIR-Triggered Hyperthermal Effect of Polythiophene Nanoparticles Synthesized by Surfactant-Free Oxidative Polymerization Method on Colorectal Carcinoma Cells

“…All in all, development of less aggressive and more effective therapies, compared to those of conventional ones, is necessary in the treatment of colorectal cancer. Since the last decade, cancer treatment by carcinoma cell ablation methods is attracting more research attention [ 9 , 10 ]. Radiofrequency ablation (RFA), microwave ablation (MWA), and laser ablation (LA) methods have been shown to be more effective in the cancer cell treatment by thermal ablation modality [ 11 ].…”