Polydopamine-coated 3D-printed β-tricalcium phosphate scaffolds to promote the adhesion and osteogenesis of BMSCs for bone-defect repair: mRNA transcriptomic sequencing analysis

Sun, Xin; Jiao, Xia; Wang, Zengguang; Ma, Jie; Wang, Tianchang; Zhu, Dan; Li, Han; Tang, Liang; Li, Heyue; Wang, Changde; Li, Yiming; Chen, Xu; Wang, Jinwu; Gan, Yaogai; Jin, Wenjie

doi:10.1039/d2tb02280j

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…For example, liposomes that mimic biological membranes can be designed to encapsulate both hydrophilic and hydrophobic bioactive agents. Another example of bioinspiration is the mussel-inspired polydopamine (PDA) coating which is a convenient and effective approach to surface modification [269]. This strategy gives rise to effective nanocarriers for delivery bioactives like CUR [266].…”

Section: "Green" Approaches To Design Obnsmentioning

confidence: 99%

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Petrovic,

Barbinta-Patrascu

2023

Materials

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“Green” strategies to build up novel organic nanocarriers with bioperformance are modern trends in nanotechnology. In this way, the valorization of bio-wastes and the use of living systems to develop multifunctional organic and biogenic nanocarriers (OBNs) have revolutionized the nanotechnological and biomedical fields. This paper is a comprehensive review related to OBNs for bioactives’ delivery, providing an overview of the reports on the past two decades. In the first part, several classes of bioactive compounds and their therapeutic role are briefly presented. A broad section is dedicated to the main categories of organic and biogenic nanocarriers. The major challenges regarding the eco-design and the fate of OBNs are suggested to overcome some toxicity-related drawbacks. Future directions and opportunities, and finding “green” solutions for solving the problems related to nanocarriers, are outlined in the final of this paper. We believe that through this review, we will capture the attention of the readers and will open new perspectives for new solutions/ideas for the discovery of more efficient and “green” ways in developing novel bioperformant nanocarriers for transporting bioactive agents.

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Section: "Green" Approaches To Design Obnsmentioning

confidence: 99%

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Petrovic,

Barbinta-Patrascu

2023

Materials

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“…Moreover, in vitro and in vivo results indicated that PDA-mediated cell adhesion has a positive effect on cartilage tissue regeneration, and it could combine with CS-PAM to achieve synergistic effects for facilitating cartilage repair without growth factors ( Figure 8 ) (Han et al., 2018 ). Specifically, PDA coating could promote the adhesion, proliferation, and osteogenic differentiation of the bone marrow mesenchymal stem cells (BMSCs) through modulating the FAK signal pathway, p38 signal pathway, calcium signal pathway, Wnt signal pathway, and TGF-β signaling pathways (Wang et al., 2019 ; Sun et al., 2023 ).…”

Section: The Mechanism Of Pda In Adsmentioning

confidence: 99%

Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

Wu,

Hong,

Shen

et al. 2023

Drug Delivery

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The conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs.

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Mild Thermotherapy‐Assisted GelMA/HA/MPDA@Roxadustat 3D‐Printed Scaffolds with Combined Angiogenesis‐Osteogenesis Functions for Bone Regeneration

You,

Li,

Wang

et al. 2024

Adv Healthcare Materials

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Early reconstruction of the vascular network is a prerequisite to the effective treatment of substantial bone defects. Traditional 3D printed tissue engineering scaffolds designed to repair large bone defects do not effectively regenerate the vascular network, and rely only on the porous structure within the scaffold for nutrient transfer and metabolic waste removal. This leads to delayed bone restoration and hence functional recovery. Therefore, strategies for generation scaffolds with the capacity to efficiently regenerate vascularization should be developed. In this study, we loaded roxarestat (RD), which can stabilize HIF‐1α expression in a normoxic environment, onto the mesopore polydopamine nanoparticles (MPDA@RD) to enhance the reconstruction of vascular network in large bone defects. Subsequently, MPDA@RD was mixed with GelMA/HA hydrogel bioink to fabricate a multifunctional hydrogel scaffold (GHM@RD) through 3D printing. In vitro results showed that the GHM@RD scaffolds achieved good angiogenic‐osteogenic coupling by activating the PI3K/AKT/HSP90 pathway in BMSCs and the PI3K/AKT/HIF‐1α pathway in HUVECs under mild thermotherapy. In vivo experiments revealed that RD and mild hyperthermia synergistically induced early vascularization and bone regeneration of critical bone defects. In conclusion, the designed GHM@RD drug delivery scaffold with mild hyperthermia holds great therapeutic value for future treatment of large bone defects.This article is protected by copyright. All rights reserved

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Polydopamine-coated 3D-printed β-tricalcium phosphate scaffolds to promote the adhesion and osteogenesis of BMSCs for bone-defect repair: mRNA transcriptomic sequencing analysis

Abstract: Cellular bioactivity and tissue regeneration can be affected by coatings on tissue-engineered scaffolds. Mussel-inspired polydopamine (PDA) is a convenient and effective approach to surface modification. Therefore, 3D-printed β-tricalcium phosphate (β-TCP)...

Cited by 6 publications

References 54 publications

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

Mild Thermotherapy‐Assisted GelMA/HA/MPDA@Roxadustat 3D‐Printed Scaffolds with Combined Angiogenesis‐Osteogenesis Functions for Bone Regeneration

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