Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect

Abstract

Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe3O4 particles. Compared with magnetic Fe3O4 particles and PDA nanospheres, the core-shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T2-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe3O4 particles and PDA nanospheres alone.

Mitochondria‐Targeting Magnetic Composite Nanoparticles for Enhanced Phototherapy of Cancer

“…Then PDA layer is coated on the surface of Fe 3 O 4 cores by the self‐polymerization of dopamine and can be visualized clearly in the TEM image (Figure bii). Considering the influence of PDA layer thickness on the photothermal effect of the composite nanoparticles, Fe 3 O 4 @PDA with a 20 nm thick PDA layer is used (as measured in TEM images). After PDA coating, the hydrodynamic diameter of the particles increases from 176 to 208 nm as measured with dynamic light scattering (DLS, Table S1, Supporting Information).…”

A pH-responsive zinc (II) metalated porphyrin for enhanced photodynamic/photothermal combined cancer therapy

“…2i and Fig. S4f), which was better than that of some traditional inorganic agents, such as Fe 3 O 4 @PDA-5 (13.1%) and Cu 9 S 5 (25.7%) [31,32]. And the individually PDT and PTT effects as controls can refer to our group's previous work [33].…”

Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

“…[ 15,16 ] By contrast, Fe 3 O 4 is known to shorten the T 2 relaxation, and many efforts have been also devoted on the constructing of PDA–Fe 3 O 4 based T 2 ‐weighted contrast agents. [ 17,18 ] Additionally, noble metals and metal oxides that possesses catalytic activities can be loaded on PDA matrix to achieve improved whole catalytic performance. The PDA functionalization of noble metal nanocatalysts significantly improved their colloidal stability that was critical for maintaining the catalytic activity in solution.…”