Polyelectrolyte complex containing silver nanoparticles with antitumor property on Caco-2 colon cancer cells

Martins, Alessandro F.; Follmann, Heveline D.M.; Monteiro, Johny P.; Bonafé, Elton Guntendorfer; Nocchi, Samara Requena; Silva, Cleiser T.P.; Nakamura, Celso Vataru; Girotto, Emerson M.; Rubira, Adley F.; Muniz, Edvani C.

doi:10.1016/j.ijbiomac.2015.05.036

Cited by 37 publications

(14 citation statements)

References 30 publications

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“…Several methodologies for TMC synthesis are described in the literature. [34][35][36] Cs reduction can be easily mediated by iodomethane in sodium iodide presence and strong alkaline condition, using N-methyl-2-pyrrolidone (NMP) as solvent. 37,38 Some authors reported the use of dimethylsulfate like reduction agent instead iodomethane, because it has higher stability and it can be used as solvent in the reaction for TMC production as well.…”

Section: Methodologies To Convert Chitinderivatives Into Hydrogelmentioning

confidence: 99%

Recent Advances in Designing Hydrogels from Chitin and Chitin-Derivatives and their Impact on Environment and Agriculture: A Review

Pereira¹,

Martins²,

Paulino³

et al. 2017

Rev. Virtual Quim.

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Resumo: Nosso objetivo é mostrar e discutir os dados mais relevantes sobre a abordagem de síntese e a caracterização de hidrogéis à base de quitina e derivados de quitina, como a quitosana, bem como suas aplicações em diversas tecnologias de materiais. A relevância atual e futura dos materiais à base de quitina, quitosana e derivados foi verificada pelo impressionante número de publicações científicas e tecnológicas (tanto papéis como patentes) que aparecem no dia-a-dia. Os hidrogéis, que apresentam propriedades semi-líquidas e semi-sólidas, tornaram-se uma grande promessa para aplicações onde o uso eficiente da água é essencial para melhorar as propriedades físico-químicas dos solos áridos. Eles também são eficazes no tratamento de águas contaminadas com corantes, chumbo cádmio, mercúrio, níquel e assim por diante, minimizando o impacto ambiental. Palavras-chave:Hidrogel; polissacarídeo; polímero superabsorbente; condicionador de solo; recuperação de água. AbstractOur purpose is to show and discuss the most relevant data on the synthesis approach and the characterization of hydrogels based on chitin and chitin-derivatives, such as chitosan, as well as their applications in several materials technologies. The current and future relevance of materials based on chitin, chitosan and derivatives have been verified by the impressive number of scientific and technological publications (both papers and patents) that appears day-by-day. The hydrogels, which show half liquid-like and half solid-like properties, have become a great promise for applications where the efficient use of water is essential to improve the physical-chemical properties of the arid soils. They are also effective in treatment of waters contaminated with dyes, lead cadmium, mercury, nickel, and so on, minimizing the environmental impact.

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Section: Methodologies To Convert Chitinderivatives Into Hydrogelmentioning

confidence: 99%

Recent Advances in Designing Hydrogels from Chitin and Chitin-Derivatives and their Impact on Environment and Agriculture: A Review

Pereira¹,

Martins²,

Paulino³

et al. 2017

Rev. Virtual Quim.

View full text Add to dashboard Cite

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“…The cationic property of TMC allows its association with polyanionic macromolecules, like heparin, sodium alginate, among others [20,21]. TMC/heparin multilayer thin films carried out from the layer-by-layer assembly [20,22].…”

Section: Most Recent Tmc Applicationsmentioning

confidence: 99%

N,N,N-Trimethyl Chitosan and Its Potential Bactericidal Activity: Current Aspects and Technological Applications

Facchi¹,

Facchi²

2016

J Infect Dis Ther

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N,N,N-Trimethyl chitosan (TMC) is one of most important chitosan derivative with stronger bactericidal property. Currently, the TMC has been attracted considerable attention, because it contains quaternized ammonium moieties ( -+ N(CH 3 ) 3 ) in its network. Its cationic property leads to a renowned bactericidal power. Besides, TMC has appropriate biocompatibility, biodegradability, mucoadhesive capacity and greater solubility at pH close to physiological condition regarding chitosan. In this way, there are not sources regarding revision papers toward TMC bactericidal action. So, this revision work reports the TMC potential to be applied in many fields, depicting its bactericidal performance, as well as, its bactericidal mechanism and some current technological aspects that must be considered.

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“…This previous study suggested that the antibacterial activity of the beads loaded with AgNPs of 3.3 mg/ml might be from the silver ion (Ag + ) released into the system [6]. Furthermore, another study reported that no Ag + was released from N,N,N-trimethyl chitosan/alginate/AgNP beads in buffer, pH 2 but this release could be observed in buffer, pH 7.4 [9]. This might be because of electric repulsions between hydronium ion (H 3 O + ) and the positive charge of chitosan/alginate beads, which could inhibit the swelling of the beads and the release of Ag + in buffer, pH 2 [9].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, another study reported that no Ag + was released from N,N,N-trimethyl chitosan/alginate/AgNP beads in buffer, pH 2 but this release could be observed in buffer, pH 7.4 [9]. This might be because of electric repulsions between hydronium ion (H 3 O + ) and the positive charge of chitosan/alginate beads, which could inhibit the swelling of the beads and the release of Ag + in buffer, pH 2 [9]. Moreover, the carboxylic group (-COOH) of alginate are not ionized at pH 2, which will also decrease the release of Ag + from the beads [9].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Chitosan and Alginate Concentration on Size and Bactericidal Activity against <i>Escherichia coli</i> of Chitosan/Alginate/Silver Nanoparticle Beads

Mahasawat

Hlongkeaw

Charoenrit

2016

AMM

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Silver nanoparticles have been used in combination with biological polymer for antibacterial application. This study prepared chitosan/alginate/AgNP beads with varying chitosan and alginate concentration to use as an antibacterial material. The sizes of neat beads were larger (1286 ± 172, 1344 ± 142 and 1529 ± 73 μm for C1, C2 and C3, respectively) with increasing concentration of chitosan and alginate. Moreover, smaller beads were observed for the chitosan/alginate/AgNP beads, in which their sizes were 1151 ± 201, 1261 ± 204 and 1324 ± 198 µm for S1, S2 and S3, respectively, when compared to the chitosan/alginate beads. Furthermore, the minimum bactericidal concentration (MBC) of chitosan/alginate/AgNP beads against E. coli was 10, 10 and 3 µg/ml for S1, S2 and S3, respectively. This study suggested that the beads with the higher concentration of chitosan and alginate resulted in the greater bactericidal activity. Therefore, the chitosan/alginate/AgNP beads prepared in this study showed the bactericidal activity which can be used for antibacterial application.

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Polyelectrolyte complex containing silver nanoparticles with antitumor property on Caco-2 colon cancer cells

Cited by 37 publications

References 30 publications

Recent Advances in Designing Hydrogels from Chitin and Chitin-Derivatives and their Impact on Environment and Agriculture: A Review

Recent Advances in Designing Hydrogels from Chitin and Chitin-Derivatives and their Impact on Environment and Agriculture: A Review

N,N,N-Trimethyl Chitosan and Its Potential Bactericidal Activity: Current Aspects and Technological Applications

Effect of Chitosan and Alginate Concentration on Size and Bactericidal Activity against <i>Escherichia coli</i> of Chitosan/Alginate/Silver Nanoparticle Beads

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