Polyelectrolyte complex of carboxymethyl starch and chitosan as drug carrier for oral administration

Assaad, Elias; Wang, Yu Juan; Zhu, X. X.; Mateescu, Mircea Alexandru

doi:10.1016/j.carbpol.2011.01.048

Cited by 84 publications

(45 citation statements)

References 34 publications

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“…Several types of hydrogels have been prepared by noncovalent crosslinking, incorporating anionic polymers, such as carboxymethylcellulose, carboxymethylated starch or alginic acid, on cationic polymers like chitosan (polyelectrolyte complexation) [5][6][7][8][9][10]. Also, the same anionic polymers have been used with CaCl 2 (ionotropic gelation) [11,12] or a mix of polymers with the salt [13,14].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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“…Isso sugere uma maior interação entre a QT e GCCM do que, por exemplo, entre GCCM e água. Esse comportamento é semelhante ao do CPE de quitosana e amido carboximetilado, relatado por Assaad e colaboradores [41] onde a mudança de pH provocou uma diminuição da capacidade de intumescimento.…”

Section: Ensaio De Intumescimentounclassified

“…O espectro da QT apresenta bandas de absorção características de quitosana em 1653 e 1586 cm -1 , atribuídas a vibrações de estiramento -CONH 2 , e duas bandas a 2926 e 2879 cm -1 , devido ao estiramento C-H. As bandas em aproximadamente 1420 e 1377 cm -1 foram atribuídas à deformação angular simétrica C-H de grupos metilênicos [41,43] . O espectro da GCCM mostra bandas características de polissacarídeos, como às que estão em 3500-3000 cm As esferas apresentam espectros com bandas similares a ambos os polissacarídeos, confirmando a formação do complexo.…”

Section: Espectroscopia De Absorção Na Região Do Infravermelhounclassified

“…O espectro da GCCM mostra bandas características de polissacarídeos, como às que estão em 3500-3000 cm As esferas apresentam espectros com bandas similares a ambos os polissacarídeos, confirmando a formação do complexo. A semelhança entre os espectros de FTIR dos complexos polieletrolíticos formados a partir de polissacarídeos aniônicos e quitosana e os espectros dos seus materiais de partida foi relatada em outros estudos [22,24,41,44] . Ombros em torno de 1730 e 1540 cm -1 poderiam ser atribuídos, respectivamente, a grupos -COOH e -NH 3 + .…”

Section: Espectroscopia De Absorção Na Região Do Infravermelhounclassified

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Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

et al. 2015

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ResumoEsferas de goma do cajueiro carboximetilada e quitosana foram produzidas via complexação polieletrolítica. As esferas foram modificadas quimicamente de modo a obter-se sistemas estáveis em meio ácido e que apresentassem uma resposta de intumescimento diferenciado frente à variação de pH. As esferas foram modificadas por reacetilação da quitosana e por reticulação com epicloridrina, glutaraldeído e genipina. As esferas reticuladas foram caracterizadas por meio de técnicas como: espectroscopia de absorção no infravermelho, análise termogravimétrica, microscopia eletrônica de varredura e quanto à solubilidade em pH 1,2 e ao intumescimento. As esferas de goma do cajueiro carboximetilada e quitosana reacetilada, e as esferas reticuladas com epicloridrina apresentaram baixa resistência à dissolução em pH 1,2. Entretanto, as esferas reticuladas com glutaraldeído e genipina apresentaram resistência à dissolução e baixo coeficiente de difusão. As esferas reticuladas com genipina apresentaram um grau de intumescimento maior do que as esferas reticuladas com glutaraldeído nas concentrações de 3% e 5% (massa/volume). As esferas reticuladas com genipina apresentaram intumescimento responsivo à variação de pH e estabilidade em pH 1,2, indicando que esses sistemas possuem potencial para uso em sistemas de liberação controlada de fármacos por via oral. PalavrasTchave: goma do cajueiro, carboximetilação, quitosana, reticulação. AbstractChitosan/carboxymethylated cashew gum beads were produced via polyelectrolytic complexation. The beads were chemically modified to achieve stable acidic medium and to provide a swelling response in different pH. The beads were modified by chitosan reacetylation and by crosslinking with epichlorohydrin, glutaraldehyde and genipin. The beads were characterized by techniques such as: infrared spectroscopy, thermogravimetry, scanning electron microscopy and regarding their solubility at pH 1.2 and swelling. The beads of carboxymethyl cashew gum and reacetylated chitosan and those crosslinked with epichlorohydrin had low resistances to dissolution at pH 1.2. However, the beads crosslinked with glutaraldehyde and genipin showed resistance to dissolution along with low diffusion coefficients. Moreover, beads crosslinked with genipin presented a higher degree of swelling than beads crosslinked with glutaraldehyde at concentrations of 3% and 5% (weight/volume). Beads crosslinked with genipin presented responsive behavior to pH variation and stability at pH 1.2, indicating that these systems have potential for use in controlled drug delivery systems for oral administration.

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“…When the CMS tablets were transferred into a high pH fluid (SIF, pH 6.8), protons started to exchange with cations between the matrix and aqueous medium. This hydration facilitated the swelling, diffusion and erosion of the matrix, as well as the release of bioactive agents (Assaad et al, 2011). CMS is lately added to tablets as a pH-sensitive excipient to protect bioactive agents from being destructed by strong acidic gastric fluids.…”

Section: Carboxymethyl Starchmentioning

confidence: 99%

Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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In recent years, polysaccharides, including starch and its derivatives, have been widely used in the pharmaceutical industry, including as diluents, fillers, binders, disintegrants and glidants. The use of native starch as excipient in extended-release tablets is limited due to its low compactibility and enzymatic degradability, leading to the formation of weakly structured tablets. To overcome these limitations and expand the application of starch as an excipient, researchers have modified starch by physical and chemical methods, as well as by enzymatic hydrolysis. Some starch derivatives, including retrograded starch, pregelatinized starch, carboxymethyl starch, starch acetate, cross-linked starch and grafted starch have recently been introduced as excipients in oral tablets to control drug release. In this review, applications of starch and its derivatives as extended release excipients are reviewed and future frontiers are described.

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Polyelectrolyte complex of carboxymethyl starch and chitosan as drug carrier for oral administration

Cited by 84 publications

References 34 publications

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Efeito da modificação química na solubilidade e intumescimento de microesferas à base de goma do cajueiro carboximetilada e quitosana

Recent advances of starch-based excipients used in extended-release tablets: a review

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