Polyelectrolyte Complexes of Chitosan with Sodium Carboxymethyl Cellulose in Water–Alcohol Media and Microcapsules Based on Them

Shilova, S. V.; Mirgaleev, G. M.; Tret’yakova, A. Ya.; Barabanov, V. P.

doi:10.1134/s0965545x20050156

Cited by 7 publications

(1 citation statement)

References 30 publications

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“…[ 4–7 ] Amino groups and acetamide groups in CH macromolecules provide it with an additional important capacity for complexation with various organic and inorganic compounds and cooperative interactions in aqueous media that result in formation of polyelectrolyte complexes. [ 8–11 ] Derivatives of alginic acid represent promising polymers for synthesis of such complexes. Sodium alginate (Alg–Na) produced from brown seaweed exhibits good gel‐forming properties in the presence of doubly charged cations (e.g., calcium ions) and is used as a component of various drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Alginate/chitosan hydrogels as perspective transport systems for cefotaxime

et al. 2023

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This work reports synthesis of pH‐responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH‐dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer–Peppas model revealed a non‐Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime–chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan–cefotaxime complexation considering the influence of a solvent.

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Section: Introductionmentioning

confidence: 99%