Polyelectrolyte mediated formation of hydroxyapatite microspheres of controlled size and hierarchical structure

Wang, Yongsheng; Hassan, Meer Saiful; Gunawan, Poernomo; Lau, Raymond; Wang, Xin; Xu, Rong

doi:10.1016/j.jcis.2009.07.023

Cited by 72 publications

(35 citation statements)

References 59 publications

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“…The solubility of HA (log K sp = À118.268) [37] is much lower than that of CaCO 3 (log K sp,vaterite = À7.913) [5]. As such, the anion replacement of CO groups in HA crystals [38]. The appearance of CO 2À 3 absorption peaks at 874 cm À1 (m 2 ), 1414 cm À1 and 1466 cm À1 (m 3 ) indicates the incorporation of CO 2À 3 groups into HA lattice structure through the Btype substitution [39].…”

Section: Formation Of Hydroxyapatite (Ha) Hollow Spheresmentioning

confidence: 95%

Fast precipitation of uniform CaCO3 nanospheres and their transformation to hollow hydroxyapatite nanospheres

Wang¹,

Moo²,

Chen³

et al. 2010

Journal of Colloid and Interface Science

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150

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Section: Formation Of Hydroxyapatite (Ha) Hollow Spheresmentioning

confidence: 95%

Fast precipitation of uniform CaCO3 nanospheres and their transformation to hollow hydroxyapatite nanospheres

Wang¹,

Moo²,

Chen³

et al. 2010

Journal of Colloid and Interface Science

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150

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“…Pollen-shaped and spherical hydroxyapatite (HA, Ca 5 (PO 4 ) 3 (OH)) particles are synthesized using potassium dihydrogen phosphate (KH 2 PO 4 , Sigma-Aldrich), calcium nitrate tetrahydrate (Ca(NO 3 ) 2 ⋅4H 2 O, Sigma-Aldrich), poly (sodium-4-styrene-sulfonate) (PSS, Sigma-Aldrich), and urea (Sigma-Aldrich) (19). Thirty milliliters of KH 2 PO 4 (0.02 M) solution is mixed with 50 ml of Ca(NO 3 ) 2 ⋅4H 2 O (0.02 M) solution.…”

Section: Experimental Preparationmentioning

confidence: 99%

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

2009

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Abstract. The shape effects of dry particles on flowability, aerosolization, and deposition properties in inhalation drug delivery are studied. The properties are compared with similar size range particles of different shapes such as sphere, needle, cube, plate, and pollen. Flowability of the particles is characterized by Carr's compressibility index and angle of slide (θ) method. The aerosolization and deposition properties of the particles are studied in vitro using an eight-stage Anderson cascade impactor with a Rotahaler®. Pollen-shaped particles are found to exhibit better flowability, higher emitted dose, and higher fine particle fraction than particles of other shapes in similar size range. They showed minimum θ of 35°and maximum emitted dose of 87% and fine particle fraction of 16%. The use of pollen-shaped particles can be a potential improvement in dry particle inhalation.

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“…Ortega et al 52 used functionalized silica as a template for the nucleation and growth of HA coatings under mild conditions, with an aging period of 6 hours. Wang et al 53 employed poly(styrene sulfonate) as a modifier in the synthesis of HA microspheres, with controlled size and hierarchical structure by hydrothermal method. Ryu et al 54 reported the synthesis of polydopamine-assisted HA inspired by the adhesion mechanism of mussels via a biomineralizing route.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically nanostructured hydroxyapatite: hydrothermal synthesis, morphology control, growth mechanism, and biological activity

2012

IJN

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Hierarchically nanosized hydroxyapatite (HA) with flower-like structure assembled from nanosheets consisting of nanorod building blocks was successfully synthesized by using CaCl 2 , NaH 2 PO 4 , and potassium sodium tartrate via a hydrothermal method at 200°C for 24 hours. The effects of heating time and heating temperature on the products were investigated. As a chelating ligand and template molecule, the potassium sodium tartrate plays a key role in the formation of hierarchically nanostructured HA. On the basis of experimental results, a possible mechanism based on soft-template and self-assembly was proposed for the formation and growth of the hierarchically nanostructured HA. Cytotoxicity experiments indicated that the hierarchically nanostructured HA had good biocompatibility. It was shown by in-vitro experiments that mesenchymal stem cells could attach to the hierarchically nanostructured HA after being cultured for 48 hours. Objective: The purpose of this study was to develop facile and effective methods for the synthesis of novel hydroxyapatite (HA) with hierarchical nanostructures assembled from independent and discrete nanobuilding blocks. Methods: A simple hydrothermal approach was applied to synthesize HA by using CaCl 2 , NaH 2 PO 4 , and potassium sodium tartrate at 200°C for 24 hours. The cell cytotoxicity of the hierarchically nanostructured HA was tested by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Results: HA displayed the flower-like structure assembled from nanosheets consisting of nanorod building blocks. The potassium sodium tartrate was used as a chelating ligand, inducing the formation and self-assembly of HA nanorods. The heating time and heating temperature influenced the aggregation and morphology of HA. The cell viability did not decrease with the increasing concentration of hierarchically nanostructured HA added. Conclusion: A novel, simple and reliable hydrothermal route had been developed for the synthesis of hierarchically nanosized HA with flower-like structure assembled from nanosheets consisting of nanorod building blocks. The HA with the hierarchical nanostructure was formed via a soft-template assisted self-assembly mechanism. The hierarchically nanostructured HA has a good biocompatibility and essentially no in-vitro cytotoxicity.

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Polyelectrolyte mediated formation of hydroxyapatite microspheres of controlled size and hierarchical structure

Cited by 72 publications

References 59 publications

Fast precipitation of uniform CaCO3 nanospheres and their transformation to hollow hydroxyapatite nanospheres

Fast precipitation of uniform CaCO3 nanospheres and their transformation to hollow hydroxyapatite nanospheres

Effect of Particle Shape on Dry Particle Inhalation: Study of Flowability, Aerosolization, and Deposition Properties

Hierarchically nanostructured hydroxyapatite: hydrothermal synthesis, morphology control, growth mechanism, and biological activity

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