Polyelectrolyte multilayers and capsules: S-layer functionalization for improving stability and biocompatibility

Habibi, Neda; Pastorino, Laura; Babolmorad, Ghazal; Ruggiero, Carmelina; Guda, Teja; Ong, Joo L.

doi:10.1016/j.jddst.2016.12.004

Cited by 8 publications

(11 citation statements)

References 33 publications

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“…In the literature, there are numerous examples of the application, e.g., in the field of membranes [16]. Moreover, there are many studies dealing with surface modifications using polyelectrolyte multilayers for obtaining surfaces with antibacterial [17,18], sensory [19], or biocompatible properties [20].…”

Section: Introductionmentioning

confidence: 99%

Ion-Specific and Solvent Effects on PDADMA–PSS Complexation and Multilayer Formation

Jukić

Korade

Milisav

et al. 2021

Colloids and Interfaces

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Among various parameters that influence the formation of polyelectrolyte complexes and multilayers, special emphasis should be placed on ion-specific and solvent effects. In our study, we systematically examined the above-mentioned effects on poly(diallyldimethylammonium chloride) (PDADMACl)-sodium poly(4-styrenesulfonate) (NaPSS) complexation in solution and at the surface by means of dynamic light scattering, ellipsometry and atomic force microscopy measurements. As solvents, we used water and water/ethanol mixture. The obtained results confirm the importance of ion-specific and solvent effects on complexes prepared in solution, as well as on multilayers built up on a silica surface. The experiments in mixed solvent solution showed that at a higher ethanol mole fraction, the decrease in monomer titrant to titrand ratio, at which the increase in the size of complexes is observed, takes place. The difference between chloride and bromide ions was more pronounced at a higher mole fraction of ethanol and in the case of positive complex formation, suggesting that the larger amount of bromide ions could be condensed to the polycation chain. These findings are in accordance with the results we obtained for polyelectrolyte multilayers and could be helpful for designing polyelectrolyte multilayers with tuned properties needed for various applications, primarily in the field of biomedicine.

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Section: Introductionmentioning

confidence: 99%

Ion-Specific and Solvent Effects on PDADMA–PSS Complexation and Multilayer Formation

Jukić

Korade

Milisav

et al. 2021

Colloids and Interfaces

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“…They were negatively charges, due to carboxylic acid groups on the polyguluronate units of alginate, and served as templates for LbL deposition of polyelectrolytes [50, 51]. The most widely used and well-studied polyelectrolyte pair for LbL deposition in drug delivery applications is PAH and PSS [29, 30, 41–43], which was chosen for this study. The positively charged PAH, having one amine group per monomer unit, was chosen as the first layer to deposit on the negatively charged Alg-Ms, and electrostatic interactions promoted the formation of this first PAH layer and additional PSS-PAH alternating layers.…”

Section: Resultsmentioning

confidence: 99%

“…The size of LbL-Alg-Ms was basically the same as that of Alg-Ms (Table 2). The indifference in the size of Alg-Ms and LbL-Alg-Ms was due to the relatively thin polyelectrolyte bilayer [43, 53] (10–50 nm) as compared to the size of microgels (~ 330 μm).…”

Section: Resultsmentioning

confidence: 99%

“…Since most commonly used characterization techniques, such as atomic force microscopy (AFM), for quantifying polyelectrolyte layers deposited on planar surfaces or on nano/microparticles [32, 43] could not be easily applied to our large microgels (~ 330 μm in radius) with rough surfaces, the exact thickness of the PAH/PSS layer on our microgels was not measured. The difficulty stemmed from the presence of alginate core that, even with a complete de-gelation, could not diffuse out of the PAH/PSS membrane.…”

Section: Resultsmentioning

confidence: 99%

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Layer-by-layer polyelectrolyte coating of alginate microgels for sustained release of sodium benzoate and zosteric acid

Wang

Newby

2018

Journal of Drug Delivery Science and Technology

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The potential of sustaining release of very small (Mw < 250 g/mol) hydrophilic drugs up to several days from layer-by-layer (LbL) polyelectrolyte coated alginate microgels (Alg-Ms) was investigated. One purpose is to minimize post-surgical adhesions, which develop in 12 h to 3 days after surgery. The LbL polyelectrolyte layer would serve as a diffusion barrier for their release. The LbL polyelectrolyte bilayers were prepared using poly(allylamine) (PAH) and poly(styrene sulfonate) (PSS). Sodium benzoate (NaB, Mw = 144 g/mol) and zosteric acid (ZA, Mw = 244 g/mol), two anti-inflammatory and anti-microbial compounds, were used as model drugs. A higher number of PAH/PSS bilayer lead to a greater sustained release of both drugs, and with 4 bilayers, the release of NaB and ZA was prolonged from 24 h to 72 h and 120 h, respectively. Fitting the data to the Ritger-Peppas’ equation showed that as the bilayer number increased, the release constant and/or exponent decreased, indicating the LbL PAH/PSS bilayer effectively reduced the permeability of these two very small hydrophilic drugs. The ability to prolong the release of such small hydrophilic molecules, which has rarely been investigated previously, would find broad applications in fields such as anti-adhesion treatment and antifouling coatings.

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“…The functionalization procedure was carried out on these hollow polyelectrolyte capsules, by the alternating deposition of polyelectrolytes with opposite charge onto the surface of the template(Habibi et al, 2011). The high stability and good biocompatibility of this system was shown, and the polymer degradation rate was decreased (Habibi et al, 2016).…”

Section: Bacterial S-layermentioning

confidence: 99%

Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: Set the bugs to work?

Farjadian

Moghoofei

Mirkiani

et al. 2018

Biotechnology Advances

106

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Drug delivery is a rapidly growing area of research motivated by the nanotechnology revolution, the ideal of personalized medicine, and the desire to reduce the side effects of toxic anti-cancer drugs. Amongst a bewildering array of different nanostructures and nanocarriers, those examples that are fundamentally bio-inspired and derived from natural sources are particularly preferred. Delivery of vaccines is also an active area of research in this field. Bacterial cells and their components that have been used for drug delivery, include the crystalline cell-surface layer known as "S-layer", bacterial ghosts, bacterial outer membrane vesicles, and bacterial products or derivatives (e.g. spores, polymers, and magnetic nanoparticles). Considering the origin of these components from potentially pathogenic microorganisms, it is not surprising that they have been applied for vaccines and immunization. The present review critically summarizes their applications focusing on their advantages for delivery of drugs, genes, and vaccines.

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Polyelectrolyte multilayers and capsules: S-layer functionalization for improving stability and biocompatibility

Cited by 8 publications

References 33 publications

Ion-Specific and Solvent Effects on PDADMA–PSS Complexation and Multilayer Formation

Ion-Specific and Solvent Effects on PDADMA–PSS Complexation and Multilayer Formation

Layer-by-layer polyelectrolyte coating of alginate microgels for sustained release of sodium benzoate and zosteric acid

Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: Set the bugs to work?

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