1974
DOI: 10.1128/jb.118.2.606-615.1974
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Polyelectrolyte Nature of Bacterial Teichoic Acids

Abstract: Several physicochemical properties of the teichoic acid of Bacillus subtilis 168 have been determined. The teichoic acid partial specific volume was found to be 0.57 ml/g. The apparent weight-average molecular weight of the polymer was 24,800. Sedimentation was strongly dependent on solvent. The sedimentation coefficient of the teichoic acid was found to have a value of s25w' = 1.90S. In

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Cited by 50 publications
(29 citation statements)
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“…We could not detect fibronectin on HeLa cells with anti-fibronectin antibody (data not shown), suggesting that fibronectin plays little, if any, role in the binding of teichoic acid to HeLa cells. Teichoic acid also has an affinity with cations, especially magnesium (12,19), whereas the binding of teichoic acid to HeLa cells was not significantly affected by the magnesium or calcium concentration in the buffers (data not shown). From our results in this study, teichoic acid seems to bind almost specif- ically to HeLa cells but we cannot exclude the possibility that a small part of the binding is through cations to HeLa cells in a nonspecific manner.…”
Section: Discussionmentioning
confidence: 94%
“…We could not detect fibronectin on HeLa cells with anti-fibronectin antibody (data not shown), suggesting that fibronectin plays little, if any, role in the binding of teichoic acid to HeLa cells. Teichoic acid also has an affinity with cations, especially magnesium (12,19), whereas the binding of teichoic acid to HeLa cells was not significantly affected by the magnesium or calcium concentration in the buffers (data not shown). From our results in this study, teichoic acid seems to bind almost specif- ically to HeLa cells but we cannot exclude the possibility that a small part of the binding is through cations to HeLa cells in a nonspecific manner.…”
Section: Discussionmentioning
confidence: 94%
“…aYb Both bacteria were treated with the EDTA. cells, metals bound to the cell wall [19,20] may in£uence the cell surface.…”
Section: Resultsmentioning
confidence: 99%
“…Conformational changes in the WTAs are a direct result of their polyelectrolyte nature. Under various conditions of pH, ionic strength, and osmotic pressure, and in the presence of different nutrients such as amino acids, nucleotides, and oligosaccharides, WTAs can shift between an extended and a collapsed conformation (Doyle, McDannel, Streips, Birdsell, & Young, ). Such a dynamic shift helps to regulate the exposure of cell wall peptidoglycan to antimicrobials, especially large molecules such as lytic enzymes, thus rapidly adjusting cell resistance (X. Wu et al, ; X. Wu, Kwon, et al, ).…”
Section: Discussionmentioning
confidence: 99%