Polyelectrolyte Stabilized Drug Nanoparticles via Flash Nanoprecipitation: A Model Study With β-Carotene

Zhu, Zhenbang; Margulis‐Goshen, Katrin; Magdassi, Shlomo; Talmon, Yeshayahu; Macosko, Christopher W.

doi:10.1002/jps.22090

Cited by 96 publications

(94 citation statements)

References 56 publications

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“…It has sometimes been observed that hydrophobic NPs prepared by FNP have the potential for self-stabilizing through electrostatic interactions [21]. For this work, CsA NPs were prepared by FNP without a block copolymer stabilizer and with either the PS 1.5k -b-PEG 5k -OH or PLA 3.8k -b-PEG 5k -OCH 3 .…”

Section: (Iv) Typical Release Curves and A Mass Balancementioning

confidence: 99%

Determining drug release rates of hydrophobic compounds from nanocarriers

D'Addio

Bukari

Dawoud

et al. 2016

Phil. Trans. R. Soc. A.

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Obtaining meaningful drug release profiles for drug formulations is essential prior to in vivo testing and for ensuring consistent quality. The release kinetics of hydrophobic drugs from nanocarriers (NCs) are not well understood because the standard protocols for maintaining sink conditions and sampling are not valid owing to mass transfer and solubility limitations. In this work, a new in vitroassay protocol based on 'lipid sinks' and magnetic separation produces release conditions that mimic the concentrations of lipid membranes and lipoproteins in vivo, facilitates separation, and thus allows determination of intrinsic release rates of drugs from NCs. The assay protocol is validated by (i) determining the magnetic separation efficiency, (ii) demonstrating that sink condition requirements are met, and (iii) accounting for drug by completing a mass balance. NCs of itraconazole and cyclosporine A (CsA) were prepared and the drug release profiles were determined. This release protocol has been used to compare the drug release from a polymer stabilized NC of CsA to a solid drug NP of CsA alone. These data have led to the finding that stabilizing block copolymer layers have a retarding effect on drug release from NCs, reducing the rate of CsA release fourfold compared with the nanoparticle without a polymer coating.This article is part of the themed issue 'Soft interfacial materials: from fundamentals to formulation'.

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Section: (Iv) Typical Release Curves and A Mass Balancementioning

confidence: 99%

Determining drug release rates of hydrophobic compounds from nanocarriers

D'Addio

Bukari

Dawoud

et al. 2016

Phil. Trans. R. Soc. A.

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“…It should be noted that since the internal configurations and dimensions of the new and old CIJ mixers are essentially the same, the mixing mechanisms of fluid components in both mixers should be grossly identical. Various studies have demonstrated the capability of the CIJM and MIVM to provide superior mixing conditions and generate organic nanoparticles in the range of 50-150 nm with the aid of amphiphilic block copolymers or polyelectrolytes as stabilizers [14,15], but none of these studies has systematically evaluated the relative performance of these two mixers in nanoparticle production.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production

Chow

Sun

Chow

2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…This suggests that processes that rely on fluid mixing, such as the FlashNanoprecipitation process or chemical reactions, are not fully optimized in this microreactor even at Re j ¼ 240, and processes can be further optimized by improving the mixing performance of the reactor. Note, however, that simply increasing the Reynolds number of operation is not necessarily expected to improve the performance for the FNP process (see, for example, Liu et al 12 and Zhu et al 38 ). A more detailed fine-tuning of the reactor design parameters may, therefore, be necessary to improve mixing performance.…”

Section: A Mixing Patternsmentioning

confidence: 99%

Micromixing visualization and quantification in a microscale multi-inlet vortex nanoprecipitation reactor using confocal-based reactive micro laser-induced fluorescence

2014

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A technique for visualizing and quantifying reactive mixing for laminar and turbulent flow in a microscale chemical reactor using confocal-based microscopic laser induced fluorescence (confocal l-LIF) was demonstrated in a microscale multi-inlet vortex nanoprecipitation reactor. Unlike passive scalar l-LIF, the reactive l-LIF technique is able to visualize and quantify micromixing effects. The confocal imaging results indicated that the flow in the reactor was laminar and steady for inlet Reynolds numbers of 10, 53, and 93. Mixing and reaction were incomplete at each of these Reynolds numbers. The results also suggested that although mixing by diffusion was enhanced near the midplane of the reactor at Re j ¼ 53 and 93 due to very thin bands of acidic and basic fluid forming as the fluid spiraled towards the center of the reactor, near the top, and bottom walls of the reactor, the lower velocities due to fluid friction with the walls hindered the formation of these thin bands, and, thus, resulted in large regions of unmixed and unreacted fluid. At Re j ¼ 240, the flow was turbulent and unsteady. The mixing and reaction processes were still found to be incomplete even at this highest Reynolds number. At the reactor midplane, the flow images at Re j ¼ 240 showed unmixed base fluid near the center of the reactor, suggesting that just as in the Re j ¼ 53 and 93 cases, lower velocities near the top and bottom walls of the reactor hinder the mixing and rection of the acidic and basic streams. Ensemble averages of line-scan profiles for the Re j ¼ 240 were then calculated to provide statistical quantification of the microscale mixing in the reactor. These results further demonstrate that even at this highest Reynolds number investigated, mixing and reaction are incomplete. Visualization and quantification of micromixing using this reactive l-LIF technique can prove useful in the validation of computational fluid dynamics models of micromixing within microscale chemical reactors. V C 2014 AIP Publishing LLC.

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Polyelectrolyte Stabilized Drug Nanoparticles via Flash Nanoprecipitation: A Model Study With β-Carotene

Cited by 96 publications

References 56 publications

Determining drug release rates of hydrophobic compounds from nanocarriers

Determining drug release rates of hydrophobic compounds from nanocarriers

Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production

Micromixing visualization and quantification in a microscale multi-inlet vortex nanoprecipitation reactor using confocal-based reactive micro laser-induced fluorescence

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