Polyendocrine autoimmunity

Barker, Jennifer M.

doi:10.1007/s11892-005-0033-0

Cited by 3 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a whole, these data suggest a possible immune system dysregulation in MD patients; if this is true, a predisposition to autoimmunity and an association with other autoimmune diseases should be observed. In this setting, thyroid gland represents a useful paradigm to be studied, given the high number of autoimmune diseases to which Hashimoto's thyroiditis has been associated [Barker, 2005]. An association between AITD and MD has been postulated for over 30 years, and was recently confirmed by our and other studies [Brenner et al, 2004;Fattori et al, 2008].…”

Section: Discussionsupporting

confidence: 62%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

View full text Add to dashboard Cite

Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Ménière’s disease (MD) and autoantibodies. Methods: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and ‘autoimmunity’, thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an ‘immune dysregulation’ in MD patients can be hypothesized.

show abstract

Section: Discussionsupporting

confidence: 62%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

View full text Add to dashboard Cite

show abstract

“…Indeed, autoimmune diseases are often associated with one another, producing a polyendocrine syndrome in which alterations in the immune system involving more than one gland generally cause hypofunctioning conditions. Multiple gland autoimmune (MGA) syndromes include a group of diseases featuring the association of one or more endocrine disorders and often of autoimmune diseases that do not involve endocrine organs [30]. Three principle types of MGA on the grounds of the involved glands and organs have been described.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryVarious aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66·7% TPO-Ab and 33·3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66·7% TPO-Ab and 33·3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0·0001 versus group A and group B) had significant autoantibody levels (68·4% TPO-Ab; 15·8% TPO-Ab + TR-Ab; 10·5% Tg-Ab; 5·2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.

show abstract

“…Fattori et al [20] further discussed that pendrin, associated with Pendred syndrome, may be a target for an autoantigen as it is expressed in both the thyroid gland and inner ear. Additionally, Fattori et al [20] suggested that autoantibodies in MD may predispose patients to other autoimmune diseases and manifest clinically as polyendocrine syndrome including multiple gland autoimmune syndromes [30]. For example, Hashimoto’s thyroiditis has been seen in multiple gland autoimmune syndromes such as systemic lupus erythematosus, pernicious anemia, and rheumatoid arthritis [31, 32].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Ménière’s Disease: A Comprehensive Review

Hwang¹,

Saadi²,

Patel³

et al. 2021

ORL

View full text Add to dashboard Cite

Introduction: The precise etiology of Ménière’s disease (MD) remains unknown; however, given the association of MD with serum antibodies and human leukocyte antigen (HLA) complex, several studies have proposed a relationship between MD and thyroid disorders. Similarly, multiple hypotheses exist regarding the metabolic disturbances of fluctuating thyroid hormone as a potential contributing agent in the development of MD. Methods: A total of 171 abstracts were identified and screened by 2 independent reviewers. Based on inclusion and exclusion criteria, 8 studies were selected for final analysis. Due to heterogeneity of clinical data, meta-analysis was not feasible. Results: The prevalence of autoimmune thyroid disease and hypothyroidism in MD varied significantly from 1 to 38%. Notable bias was introduced given the lack of standardization of diagnostic criteria across studies. Articles that described autoimmune thyroid-specific antibodies and HLA types also presented inconclusive results. Multiple studies noted a potential etiologic role of hypothyroidism in MD, which was often confounded by thyroxine supplementation. Conclusions: Despite a potential correlation in the medical literature between thyroid disorders and MD, there is currently no definitive causal relationship. Although most of the present medical literature focuses on autoimmunity, dysregulated thyroid hormone levels may also be implicated in the association of MD with thyroid disorders.

show abstract

Polyendocrine autoimmunity

Cited by 3 publications

References 50 publications

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Possible association between thyroid autoimmunity and Menière's disease

Thyroid Dysfunction in Ménière’s Disease: A Comprehensive Review

Contact Info

Product

Resources

About