Polyethersulfone optical fibers with thermally induced microbubbles for custom side-scattering profiles

Shabahang, Soroush; Forward, Sarah; Yun, Seok Hyun

doi:10.1364/oe.27.007560

Cited by 12 publications

(20 citation statements)

References 21 publications

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“…In order to facilitate standardizable physical/chemical/biological properties, [ 13 ] degradable and non‐degradable synthetic polymers have also been explored for optical waveguides. Polyethylene glycol diacrylate (PEGDA)‐based hydrogels, [ 14 ] polyacrylamide (PAM)‐based hydrogels, [ 15 ] polydimethylsiloxane, [ 16 ] poly(lactic acid), [ 4,7,17 ] poly(lactic‐ co ‐glycolic acid), [ 4 ] polydioxanone, [ 18 ] polyethersulfone, [ 19 ] and citrate‐based biomaterials [ 20 ] have all been reported. The waveguiding performance of these materials is far lower than optical waveguides from silica or polymers used in technical applications.…”

Section: Introductionmentioning

confidence: 99%

Printed Degradable Optical Waveguides for Guiding Light into Tissue

Feng

Zheng

Bhusari

et al. 2020

Adv Funct Materials

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Optogenetics and photonic technologies are changing the future of medicine. To implement light-based therapies in the clinic, patient-friendly devices that can deliver light inside the body while offering tunable properties and compatibility with soft tissues are needed. Here extrusion printing of degradable, hydrogel-based optical waveguides with optical losses as low as 0.1 dB cm −1 at visible wavelengths is described. Core-only and core-cladding fibers are printed at room temperature from polyethylene glycol (PEG)-based and PEG/Pluronic precursors, and cured by in situ photopolymerization. The obtained waveguides are flexible, with mechanical properties tunable within a tissue-compatible range. Degradation times are also tunable by adjusting the molar mass of the diacrylate gel precursors, which are synthesized by linking PEG diacrylate (PEGDA) with varying proportions of DL-dithiothreitol (DTT). The printed waveguides are used to activate photochemical and optogenetic processes in close-to-physiological environments. Light-triggered migration of cells in a photoresponsive 3D hydrogel and drug release from an optogenetically-engineered living material by delivering light across >5 cm of muscle tissue are demonstrated. These results quantify the in vitro performance, and reflect the potential of the printed degradable fibers for in vivo and clinical applications.

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Section: Introductionmentioning

confidence: 99%

Printed Degradable Optical Waveguides for Guiding Light into Tissue

Feng

Zheng

Bhusari

et al. 2020

Adv Funct Materials

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“…Polyethersulfone (PES) has attracted considerable attention as a high-performance super engineering plastic because of its excellent heat resistance, molding stability, and processability, as well as superior mechanical, electrical, and optical properties. [1][2][3][4][5][6][7] However, the direct thermal nanopatterning of super engineering plastics, such as PES, polyphenylene sulfide, and polyetheretherketone, still remains a challenge because it requires a high nanoimprinting temperature above the glass transition temperature of the materials. [8][9][10][11][12][13][14] In contrast, dilution solvents in PES as a nanopatterning material increase the fluidity of the nanopatterning material to obtain filling of the mold during the imprinting process.…”

Section: Methodsmentioning

confidence: 99%

Direct Nanoimprint Lithography of Polyethersulfone Using Cellulose‐Based Mold

Takei

2020

Macro Materials & Eng

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and resist materials were investigated for the expanded nanoimprint lithography and application of biomass resources. [21][22][23][24][25] Herein, high-accuracy nanopatterning of PES using dimethylformamide as a dilution solvent was obtained by direct thermal nano imprint lithography using the newly modified solvent-permeable cellulosebased mold.In summary, the 900-nm line pattern failure of PES containing dimethylformamide as a dilution solvent was solved using the solvent-permeable cellulosebased mold. The direct nanoimprint lithography using the new solvent-permeable mold and solvent-mixed super-engineering plastics has realized the surface nanostructures of PES. Experimental SectionThe structures of a) hydroxypropyl cellulose with thermally cross-linked acryloyloxyalkyl groups in the solvent-permeable cellulose-based mold, b) 2-hydroxy-2-methylpropiophenone as an ultraviolet(UV) initiator, c) azobisisobutyronitrile as a thermal initiator, d) polyethersulfone, e) dimethylformamide as a dilution solvent with high solubility for increasing the fluidity of PES, f) novolac derivatives with hydroxyl groups to react with the cross-linker to improve adhesion to polyethersulfone during the imprinting process, g) 1,3,4,6-tetrakis(methoxymethyl) glycoluril as a cross-linker, and h) pyridinium p-toluenesulfonate as an initiator are shown in Figure 1.2-Methacryloyloxyalkyl isocyanate was reacted with hydroxypropyl cellulose to add thermally cross-linked acryloyloxyalkyl groups into the hydroxypropyl cellulose to prepare the solvent-permeable cellulose-based mold. The resulting chemical reaction between 2-methacryloyloxyalkyl isocyanates and hydroxypropyl cellulose was evaluated using attenuated total reflectance Fourier transform infrared spectroscopy. [26][27][28] Methyl ethyl ketone was blended with 2-methacryloyloxyalkyl isocyanates and hydroxypropyl cellulose. The content of 2-methacryloyloxyalkyl isocyanate and hydroxypropyl cellulose in the solution was 26 wt%. The solution was stirred under a nitrogen atmosphere at 63 °C for 2.5 h, after adding triethylamine with a concentration of 7.9 wt% to the solution. Gel-permeation chromatography (HLC-8320GPC, Tosoh) was used to obtain the molecular weight of solvent-permeable cellulosebased mold. The solvent-permeable cellulose-based mold with an average molecular weight of 53 000 relative to a polystyrene standard was developed. The solvent-permeable cellulose-based mold with thermally cross-linked acryloyloxyalkyl groups was formulated with the following concentrations: 95 wt% of cellulose derivative, 2.5 wt% of 2-hydroxy-2-methylpropiophenone, and 2.5 wt% of azobisisobutyronitrile as a thermal initiator.The adhesion underlayer material on substrates, such as stainless mesh plate and silicon wafer was prepared to provide an adhesion between the substrates and patterning materials, such as PES and solvent-permeable cellulose-based mold, thereby reducing the pattern Polyethersulfone (PES) with a glass transition temperature of 224 °C is a class of high-performance super engi...

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“…The side-emitting fiber exhibits a wavelength dependency of the side glow, given by the scattering coefficient k in Equation (6), as well as by the macrobending parameters R c and a MB defined in Equations (8) and (11), respectively. The scattering coefficient of side-glow fibers exhibits an inverse proportionality vs. wavelength [50]. With respect to propagation, this accounts for a strong attenuation of short wavelengths (blue to green) for short distances and the transmission of long wavelengths (yellow to red) towards longer distances.…”

Section: Methodsmentioning

confidence: 99%

An Intra-Oral Optical Sensor for the Real-Time Identification and Assessment of Wine Intake

Faragó

Gălătuș

Hintea

et al. 2019

Sensors

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Saliva has gained considerable attention as a diagnostics alternative to blood analyses. A wide spectrum of salivary compounds is correlated to blood concentrations of biomarkers, providing informative and discriminative data regarding the state of health. Intra-oral detection and assessment of food and beverage intake can be correlated and provides valuable information to forecast the formation and modification of salivary biomarkers. In this context, the present work proposes a novel intra-oral optical fiber sensor, developed around an optical coupler topology, and exemplified on the detection and assessment of wine intake, which is accounted for example for the formation of Nε-carboxymethyllysine Advanced Glycation End-products. A laboratory proof of concept validates the proposed solution on four white and four red wine samples. The novel optical sensor geometry shows good spectral properties, accounting for selectivity with respect to grape-based soft drinks. This enables intra-oral detection and objective quality assessment of wine. Moreover, its implementation exploits the advantages of fiber-optics sensing and facilitates integration into a mouthguard, holding considerable potential for real-time biomedical applications to investigate Advanced Glycation End-products in the saliva and their connection with consumption of wine, for the evaluation of risk factors in diet-related diseases.

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Polyethersulfone optical fibers with thermally induced microbubbles for custom side-scattering profiles

Cited by 12 publications

References 21 publications

Printed Degradable Optical Waveguides for Guiding Light into Tissue

Printed Degradable Optical Waveguides for Guiding Light into Tissue

Direct Nanoimprint Lithography of Polyethersulfone Using Cellulose‐Based Mold

An Intra-Oral Optical Sensor for the Real-Time Identification and Assessment of Wine Intake

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