Polyethylene glycol as a novel solvent for extraction of crude polysaccharides from pericarpium granati

Zhou, Xinyu; Liu, Ruilin; Ma, Xue; Zhang, Zhiqi

doi:10.1016/j.carbpol.2013.10.017

Cited by 25 publications

(11 citation statements)

References 11 publications

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“…Due to the polarity and viscosity difference between water and PEG, it is important to concentrate on the selection of PEG concentration. Figure b showed that the extraction yield increased over the PEG600 concentration of 0–0.30 g/ml and then decreased over the PEG600 concentration of 0.30–0.60 g/ml, which was similar to the extraction of polysaccharides from pericarpium granati (Zhou, Liu, Ma, & Zhang, ). Thus a PEG600 concentration was set to 0.30 g/ml in the following study.…”

Section: Resultssupporting

confidence: 66%

“…However, water was still used as the extraction solvent in the hot water extraction, microwave‐assisted extraction, and ultrasound‐assisted extraction. Recently, one kind of green solvent named polyethylene glycol (PEG) has been successfully developed for the extraction of polysaccharides from pericarpium granati (Zhou, Liu, Ma, & Zhang, ), which was better than the water‐based extraction in term of the extraction yield. Therefore, it is possible to test the PEG‐based ultrasound‐assisted extraction of AAP from A. auricula .…”

Section: Introductionmentioning

confidence: 99%

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PEG‐based ultrasound‐assisted extraction of polysaccharides from superfine ground Auricularia auricular

Zhang

Wang

2017

J Food Process Preserv

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In this study, polyethylene glycol was used for the ultrasound‐assisted extraction of polysaccharides from superfine ground Auricularia auricula. The experimental factors including PEG molecule weight, PEG concentration, sample size, liquid–solid ratio, extraction temperature, and extraction time were optimized by the Box‐Behnken Design. The results showed that the optimal extraction conditions were a liquid–solid ratio of 39.27 ml/g, an extraction temperature of 91.94 °C and an extraction time of 32.44 min. Under these extraction conditions, the extraction yield of AAP was proved to be 25.75 ± 0.59%. The optimal extraction yield was well in close agreement with the value predicted by the regression model. Practical applications The PEG‐based ultrasound‐assisted extraction of polysaccharides from Auricularia auricular not only effectively decreases the extraction time, but also increases the extraction yield. Furthermore, the superfine grinding technology can greatly improve reactive surface to the largest content, thus enhancing the extraction yield.

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Section: Resultssupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

PEG‐based ultrasound‐assisted extraction of polysaccharides from superfine ground Auricularia auricular

Zhang

Wang

2017

J Food Process Preserv

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“…Guolin et al (2012) .63 min, SLR: 1:15 w/v). Recently, the use of aqueous polyethylene glycol solutions has also been proposed for the extraction of polysaccharides from Pericarpium granati (Zhou et al 2014). Although yields were not notably high, this solvent could be a good alternative to other more aggressive solvents considering its biodegradability, low flammability, nonvolatility, and stability at high temperature (Bulgariu and Bulgariu 2008).…”

Section: Pectinsmentioning

confidence: 99%

“…and enhanced energy provided by each of these techniques (Leonelli and Mason 2010). Although application of this hybrid technology results in better and sometimes more targeted extraction yields of flavorings and nutraceuticals from plants, herbs, and seeds (Cravotto and Cintas 2006;Cravotto et al 2008), its application to polysaccharide extraction is still limited (Bagherian et al 2011;Zhou et al 2014). Furthermore, these combined reactors have only been developed at laboratory scale.…”

Section: Future Trendsmentioning

confidence: 99%

Microwave-Assisted Extraction of Polysaccharides

et al. 2015

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“…As extraction will continue to provide the bulk of artemisinin for the manufacture of antimalarial drugs in the foreseeable future, people are trying to explore sustainable and green processes for artemisinin production. Poly(ethylene glycol) (PEG) has been examined as an eco-friendly reaction media for numerous organic transformations because of its relatively high thermal stability, low price, readily recyclability, and desirable biodegradable nature. , PEG has also been demonstrated to be able to extract several kinds of natural products, such as separation of polysaccharides from Tremella fuciformis , and extraction of essential oils, flavone, and coumarin compounds from medicinal plants. , Moreover, compared with the product yield from the process using conventional solvents, that from the PEG-involved process could increase by 25% . PEG might be a potential green and biocompatible solvent for artemisinin extraction.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process

Prawang

Zhang

et al. 2019

Ind. Eng. Chem. Res.

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Poly(ethylene glycol) (PEG), a kind of “green” medium, was used to extract artemisinin from the Chinese herb Artemisia annua L. to replace the traditional volatile and explosive solvents like petroleum ether, diethyl ether, etc. PEGs, with different molecular weights, show excellent ability for artemisinin extraction, and the extraction efficiency decreased with the increase of molecular weight. It was also demonstrated that ultrasonic irradiation could further enhance extraction efficiency compared with conventional water bath heating. Results indicate that the extraction amount of artemisinin from one gram of the leaves could reach 15.8 mg/g under the optimal conditions with ultrasonic power of 100 W, the temperature of 50 °C, time of 1 h in PEG-200, which were optimized by response surface method. Compared with Soxhlet extraction using petroleum ether (PE), the method developed here shows higher extraction efficiency (15.8 mg/g for PEG vs. 14.9 mg/g for PE process) and shorter extraction time (1 h vs. ca. 12 h). Additionally, artemisinin in the PEG solution can be recovered using resin adsorber. The results show that the recovery of artemisinin could reach almost 100% by D101 or H103 porous resin, and then the drug could be desorbed from the resin by ethanol or ethyl acetate. Moreover, the kinetic and mechanism studies of the extraction process revealed that ultrasonic irradiation could enhance mass transfer and the hydrogen bonding interactions between artemisinin and PEG further facilitate the separation of artemisinin from the leaves. This work provides an alternative process for efficient artemisinin extraction by using an environmentally benign medium with outfield intensification, which could be potentially extended to the production of other natural drugs.

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Polyethylene glycol as a novel solvent for extraction of crude polysaccharides from pericarpium granati

Cited by 25 publications

References 11 publications

PEG‐based ultrasound‐assisted extraction of polysaccharides from superfine ground Auricularia auricular

PEG‐based ultrasound‐assisted extraction of polysaccharides from superfine ground Auricularia auricular

Microwave-Assisted Extraction of Polysaccharides

Ultrasonic Assisted Extraction of Artemisinin from Artemisia annua L. Using Poly(Ethylene Glycol): Toward a Greener Process

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