2018
DOI: 10.1002/jnr.24225
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Polyethylene glycol solutions rapidly restore and maintain axonal continuity, neuromuscular structures, and behaviors lost after sciatic nerve transections in female rats

Abstract: Complete severance of major peripheral mixed sensory-motor nerve proximally in a mammalian limb produces immediate loss of action potential conduction and voluntary behaviors mediated by the severed distal axonal segments. These severed distal segments undergo Wallerian degeneration within days. Denervated muscles atrophy within weeks. Slowly regenerating (∼1 mm/day) outgrowths from surviving proximal stumps that often nonspecifically reinnervate denervated targets produce poor, if any, restoration of lost vol… Show more

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Cited by 36 publications
(108 citation statements)
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“…Female Sprague-Dawley rats weighing 250–300g (n = 79) were anesthetized and maintained with a small inhaled isoflurane anesthetic system (Handlebar Anesthesia, Austin, TX), as previously described for this and other basic surgical procedures in sterile conditions (Mikesh et al, 2018). A 25–35mm incision was made in the skin to expose the sciatic nerve parallel to the biceps femoris muscle.…”
Section: Methodsmentioning
confidence: 99%
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“…Female Sprague-Dawley rats weighing 250–300g (n = 79) were anesthetized and maintained with a small inhaled isoflurane anesthetic system (Handlebar Anesthesia, Austin, TX), as previously described for this and other basic surgical procedures in sterile conditions (Mikesh et al, 2018). A 25–35mm incision was made in the skin to expose the sciatic nerve parallel to the biceps femoris muscle.…”
Section: Methodsmentioning
confidence: 99%
“…Extracellular compound action potentials (CAPs) were evoked prior to and immediately following surgical procedures in all animals to assess electrophysiological function and continuity (Riley et al, 2015; Mikesh et al, 2018). Stimulating and recording electrodes were placed just proximal and just distal to the autograft or allograft and a CAP was recorded to assess whether axonal continuity was re-established across the graft.…”
Section: Methodsmentioning
confidence: 99%
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