Polyethylenimine-functionalized fibroin nanoparticles as a potential oral delivery system for BCS class-IV drugs, a case study of furosemide

Phạm, Duy Toàn; Nguyen, Thanh Lich; Nguyen, Thi Truc Linh; Nguyen, Thi Truc Phuong; Ho, Tuan Kiet; Nguyen, Ngoc Yen; Tran, Van De; Ha, Thi Kim Quy

doi:10.1007/s10853-023-08640-y

Cited by 8 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CIP loaded FNP (FNP-CIP) and CIP loaded FNP/PVA (FNP/PVA-CIP) were prepared by two different methods, the standard desolvation method and the adsorption method [ 12 ]. Both methods were mild and straight-forward, of which the desolvation process was the simple mixing of the water phase and the ethanol phase, whereas the adsorption process was the immersion of nanoparticles in the drug solution.…”

Section: Methodsmentioning

confidence: 99%

“…The D-R model characterizes the adsorption process at the solid/liquid interface, particularly for the adsorption on microporous and non-porous materials. In terms of pharmaceutical adsorption, these two models are frequently used to evaluate a drug isothermal properties [ 12 ]. The Langmuir model commonly denotes the single or multi-layer(s) drug adsorption, whereas the D-R model examines the nature of the adsorption process (physical or chemical).…”

Section: Methodsmentioning

confidence: 99%

“…Fibroin inherent amphiphilic structure allows it to self-restructure into micro-/nanoparticles with little or no catalysis [ 4 ]. Due to this unique property, as well as the biodegradability [ 5 ], biocompatibility [ 6 ], and non-cytotoxicity [ 7 ], fibroin has been increasingly utilized as nanoparticulate drug delivery systems in numerous pharmaceutical products for injection [ 8 , 9 ], topical [ 10 ], oral [ 11 , 12 ], and ocular [ 13 ] administrations. Most studies developed fibroin nanoparticles (FNP) to deliver different drugs with small/medium/big molecular structures, hydrophilic/lipophilic properties, and charged/non-charged characteristics.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Thi Phuong Thao,

Nguyen,

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Fibroin nanoparticles (FNP) have been employed in numerous biomedical applications. However, limited research has focused on the oral delivery of FNP and in-depth molecular interactions between the encapsulated drug and FNP. Therefore, this work developed the FNP, functionalized with poly(vinyl alcohol) (PVA), to orally deliver the zwitterionic ciprofloxacin, focused on the molecular interactions. The particles were formulated using both desolvation (the drug precipitated during the particles formulation) and adsorption (the drug adsorbed on the particles surfaces) methods. The optimal formula possessed a size of ~630 nm with narrow size distribution (measured by DLS method), spherical shape (determined by SEM), and moderate drug loading (confirmed by FT-IR, XRD, and DSC techniques) of ~50% for the desolvation method and ~43% for the adsorption method. More than 80% of the drug molecules resided on the particle surfaces, mainly via electrostatic forces with fibroin. The drug was physically adsorbed onto FNP, which followed Langmuir model and pseudo second-order kinetics. In the in-vitro simulated gastric condition at pH 1.2, the ciprofloxacin bound strongly with FNP via electrostatic forces, thus hindering the drug release (< 40%). Contrastingly, in the simulated intestinal condition at pH 6.8, the particles could control the drug release rates dependent on the PVA amount, with up to ~100% drug release. Lastly, the particles possessed adequate antibacterial activities on Bacillus subtilis, Escherichia coli, and Salmonella enterica, with MIC of 128, 8, and 32 μg/mL, respectively. In summary, the FNP and PVA functionalized FNP could be a potential oral delivery system for zwitterionic drugs.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Thi Phuong Thao,

Nguyen,

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

Enhanced Anti‐inflammatory Effects of Diclofenac Delivered Orally via Polyvinylpyrrolidone K30/Silk Fibroin Nanoparticles in a Murine Model of Carrageenan‐Induced Paw Edema

Di,

Ha,

Nguyen

et al. 2024

ChemMedChem

View full text Add to dashboard Cite

Diclofenac has a relatively low oral bioavailability (50‐60%) and is quickly metabolized with a half‐life of less than 1 h. Therefore, the oral therapeutic effect of diclofenac is not optimal. This research developed polyvinylpyrrolidone K30‐functionalized silk fibroin nanoparticles as an effective delivery system for diclofenac (FNPs‐PVP‐DC). The FNPs‐DC and FNPs‐PVP‐DC were formulated by two methods of adsorption and solvent exchange. Depending on the formulation factors, the obtained particles exhibited different properties of nano‐scale sizes (400‐800 nm), narrow size distribution, negatively charged surfaces (‐17 to ‐19 mV), high PVP K30 incorporation (23%‐50%), pHpzc of ~6.6, and appropriate chemical interactions. Interestingly, particles formulated by the adsorption method showed low drug encapsulation efficiencies of < 15%, whereas the solvent exchange method yielded moderate results of ~40%. The FNPs‐DC possessed aggregated patterns, while the FNPs‐PVP‐DC were more uniformly distributed. All formulations limited diclofenac release (< 20%) under gastric conditions and sustained its release in the intestinal environment. In in‐vivo carrageenan‐induced paw edema mice model, the FNPs‐PVP‐DC demonstrated a 20‐30% higher anti‐inflammatory effect and a faster onset of action (within 1 h) compared to pure diclofenac at the same dose (5 mg/kg). These findings suggest that FNPs‐PVP‐DC have promising potential as novel oral anti‐inflammatory products.

show abstract

Nanomaterial-Based Photochemical Degradation of Environmental Pollutants

Thakur,

Kumar,

Thakur

et al. 2024

Nanotechnology

View full text Add to dashboard Cite

Polyethylenimine-functionalized fibroin nanoparticles as a potential oral delivery system for BCS class-IV drugs, a case study of furosemide

Cited by 8 publications

References 35 publications

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Formulations of poly(vinyl alcohol) functionalized silk fibroin nanoparticles for the oral delivery of zwitterionic ciprofloxacin

Enhanced Anti‐inflammatory Effects of Diclofenac Delivered Orally via Polyvinylpyrrolidone K30/Silk Fibroin Nanoparticles in a Murine Model of Carrageenan‐Induced Paw Edema

Nanomaterial-Based Photochemical Degradation of Environmental Pollutants

Contact Info

Product

Resources

About