Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe<sub>3</sub>O<sub>4</sub>magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging

Molaei, Haniyeh; Zaaeri, Farzaaneh; Sharifi, Sharareh; Ramazani, Ali; Safaei, Saeed; Abdolmohammadi, Jamil; Khoobi, Mehdi

doi:10.1080/00914037.2020.1798435

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…The in vitro cell cytotoxic effects of samples were measured by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against MCF-7 (Michigan cancer foundation-7) cells. [46][47][48][49][50] The cells were initially seeded in a 96-well flat-bottomed culture plate (5 × 10 4 cells per well). Moreover, the cells were treated with various concentrations of DOX and synthesized DOX-loaded nanocarrier to determine the cytotoxicity of samples.…”

Section: Cytotoxicitymentioning

confidence: 99%

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

2023

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In this research, a novel nanocarrier is synthesized based on tragacanth as a natural polysaccharide. For this purpose, carboxymethyl tragacanth (CMT) is first synthesized from tragacanth and then it is functionalized with isocyanate (IS) groups. In another parallel synthesis, magnetite nanoparticles (MNPs) are prepared by the co-precipitation method and coated with SiO 2 to form MNPs coated SiO 2 (MNPs@SiO 2 ). Then MNPs@SiO 2 is reacted with CMT-IS to form Fe 3 O 4 @SiO 2 /CMT. In the second step, the MNPs@SiO 2 /CMT surface is aminated by reaction with 3-amino propyl triethoxy silane (APTES) and then it is reacted with folic acid (FA) as a targeting agent to form MNPs@SiO 2 /CMT/FA nanocarrier. The synthesized nanocarrier is characterized by FT-IR, SEM, EDX, TEM, XRD, VSM, TGA, and zeta potential analysis and then it is loaded with doxorubicin (DOX) as a typical anti-cancer drug. The in vitro drug release studies are carried out from the DOX-loaded nanocarrier. The pH sensitivity of the DOX-loaded nanocarrier is examined attwo different pHs. The effect of DOX-loaded nanocarrier is investigated on MCF7 human breast cancer cells and the rate of cancer cell death is determined by MTT assay and drug IC50. The changes in the morphology of the tumor cell nuclei are observed using fluorescence microscopy.

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Section: Cytotoxicitymentioning

confidence: 99%

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

2023

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“…The low pH level in malignancy tissue is due to the excess production of lactic acid, (particularly in endosomes) and reactive oxygen species (ROS) which stimulates the generation of Glutathione (GSH) to deal with ROS [ 192 ]. Molaei et al [ 193 ] formulated an iron oxide nano-system, enveloped with pHR polyethyleneimine (PEI) and amphiphilic poly-maleic anhydride-alt-1-octadecene and functionalized with FA for curcumin (CUR) delivery. The characteristics of the final NPs are collected in Table 2 .…”

Section: Stimuli-triggered Smnpsmentioning

confidence: 99%

“…The drug release at the acidic condition of TME was improved as compared to physiological pH due to the swelling property of cationic PEI via proton absorption and repulsion effects between positive charges. Furthermore, the nano-system could be a prospective candidate for theranotics purposes as MRI contrast media and also CDR [ 193 ].…”

Section: Stimuli-triggered Smnpsmentioning

confidence: 99%

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

et al. 2022

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Iron oxide nanoparticle (IONPs) have become a subject of interest in various biomedical fields due to their magnetism and biocompatibility. They can be utilized as heat mediators in magnetic hyperthermia (MHT) or as contrast media in magnetic resonance imaging (MRI), and ultrasound (US). In addition, their high drug-loading capacity enabled them to be therapeutic agent transporters for malignancy treatment. Hence, smartening them allows for an intelligent controlled drug release (CDR) and targeted drug delivery (TDD). Smart magnetic nanoparticles (SMNPs) can overcome the impediments faced by classical chemo-treatment strategies, since they can be navigated and release drug via external or internal stimuli. Recently, they have been synchronized with other modalities, e.g., MRI, MHT, US, and for dual/multimodal theranostic applications in a single platform. Herein, we provide an overview of the attributes of MNPs for cancer theranostic application, fabrication procedures, surface coatings, targeting approaches, and recent advancement of SMNPs. Even though MNPs feature numerous privileges over chemotherapy agents, obstacles remain in clinical usage. This review in particular covers the clinical predicaments faced by SMNPs and future research scopes in the field of SMNPs for cancer theranostics.

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“…Besides, the presence of carboxylate groups as an anchor allows conjugation with other biomolecules or ligands for biomedical applications. [47,48] In this study, we report a facile method to synthesize of ultrathin Gd 2 O 3 nanoplates encapsulated with PMAO polymer (Gd 2 O 3 @PMAO) as an effective-contrast agent with good biocompatibility and improved T 1 contrast effect. The characterizations of the obtained sample such as size, morphology and surface properties were investigated by using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fouriertransform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), dynamic light scattering (DLS) and Zeta potential measurements.…”

Section: Chemistryselectmentioning

confidence: 99%

“…The anhydride groups can be readily hydrolyzed, resulting in the formation of free carboxylate moieties that provide electrostatic stability to the colloid. Besides, the presence of carboxylate groups as an anchor allows conjugation with other biomolecules or ligands for biomedical applications [47,48] …”

Section: Introductionmentioning

confidence: 99%

Water‐dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent

et al. 2022

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Gadolinium oxide (Gd 2 O 3 ) nanoplates have been successfully synthesized by thermal decomposition method in the presence of oleic acid and oleylamine as surfactants. As a result, the nanoplates have average edge length and thickness around 10 nm and 1.1 nm, respectively. The hydrophobic OA/OM capped Gd 2 O 3 nanoplates were encapsulated with amphiphilic poly (maleic anhydride-alt-1-octadecene) polymer (PMAO) for phase transfer into aqueous media. The obtained Gd 2 O 3 @PMAO showed a hydrodynamic size of 32 nm with good dispersion in water solvent and stable in wide range of pH (pH = 2 � 11) and at electrolyte concentrations as high as NaCl 380 mM. In addition, the in vitro toxicity tests confirmed the biocompatibility of Gd 2 O 3 @PMAO nanoplates. The magnetic resonance imaging (MRI) result exhibited the r 1 of Gd 2 O 3 @PMAO nanoplates (16.95 mM À 1 s À 1 ) is four times higher than that of clinically used Gd-DTPA. These results suggest that the PMAO coated -Gd 2 O 3 nanoplates are potential T 1 contrast agents for in vivo MRI application.

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Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe₃O₄magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging

Cited by 8 publications

References 42 publications

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

Water‐dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent

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Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe3O4magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging

Cited by 8 publications

References 42 publications

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

Synthesis of Magnetic Nanocarrier Conjugated by Folate Based on Tragacanth and In Vitro Investigation of their Efficiency on Breast Cancer Cells

Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

Water‐dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent

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Product

Resources

About

Polyethylenimine-graft-poly (maleic anhydride-alt-1-octadecene) coated Fe₃O₄magnetic nanoparticles: promising targeted pH-sensitive system for curcumin delivery and MR imaging