Polyethylenimine (PEI)-modified poly (lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with tumor-homing bacteria facilitate high intensity focused ultrasound-mediated tumor ablation

Wang, Disen; Jiang, Feng; Wang, Lu; Tang, Yu; Zhong, Zhou; Du, Yan; Zhang, Jianzhong

doi:10.1016/j.bbrc.2021.07.061

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…Nanomaterials carrying bacteria that specifically target tumours have been developed to address this challenge. B. bifidum selectively colonises the hypoxic regions of solid tumours, which are often less accessible to chemotherapy [66]. In a study by Xiao et al, a biocompatible bacteria/nanoparticles biohybrid platform (Bif@DOX-NPs) was created [67].…”

Section: Bifidobacterium Infantis Atcc 15697mentioning

confidence: 99%

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Ghaznavi,

Hashemi,

Abolhosseini

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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The human gastrointestinal tract is colonised by a multifaceted and dynamic population of microorganisms consisting of trillions of microbes called the gut microbiota. Through extensive research using animal models and human studies, the significant contributions of gut microbiota to immune and metabolic balance, protection against pathogens, and even neurobehavioural traits have been established. Members of the genus Bifidobacterium are the first bacteria to colonise the intestinal tract in infants, and now it has been proven that they play a positive role in enhancing the host immunity, nutrient absorption, reducing and treating gastrointestinal infections, as well as improving conditions such as diarrhea, constipation, and eczema. Bacterial nanotechnology is a rapidly growing research area with great potential for improvement and the discovery of innovations in new applications of bacteria such as Bifidobacterium. In this review, we provide an up-to-date summary of the relations of nanotechnology with Bifidobacterium in various fields, including bacterial synthesis of nanoparticles, encapsulation of bacteria, bacterial toxicity of nanomaterial, application in the field of cancer targeting, and also the treatment of other diseases such as Alzheimer’s and IBD.

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Section: Bifidobacterium Infantis Atcc 15697mentioning

confidence: 99%

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Ghaznavi,

Hashemi,

Abolhosseini

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…However, to interact with the cell membranes of immune cells to facilitate phagocytosis, positively charged particles are beneficial [ 64 , 65 , 66 ]. Thus, surface modifications of PLGA particles using positively charged polymers such as polyethylenimine (PEI) [ 67 , 68 ] or chitosan (CS) [ 69 , 70 , 71 ] are commonly performed in order to shift the zeta potential towards positive. The hydrophobic nature of PLGA particles presents a challenge for the use in immunotherapy.…”

Section: Properties Of Plga Particlesmentioning

confidence: 99%

PLGA Particles in Immunotherapy

Horvath

Basler

2023

Pharmaceutics

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Poly(lactic-co-glycolic acid) (PLGA) particles are a widely used and extensively studied drug delivery system. The favorable properties of PLGA such as good bioavailability, controlled release, and an excellent safety profile due to the biodegradable polymer backbone qualified PLGA particles for approval by the authorities for the application as a drug delivery platform in humas. In recent years, immunotherapy has been established as a potent treatment option for a variety of diseases. However, immunomodulating drugs rely on targeted delivery to specific immune cell subsets and are often rapidly eliminated from the system. Loading of PLGA particles with drugs for immunotherapy can protect the therapeutic compounds from premature degradation, direct the drug delivery to specific tissues or cells, and ensure sustained and controlled drug release. These properties present PLGA particles as an ideal platform for immunotherapy. Here, we review recent advances of particulate PLGA delivery systems in the application for immunotherapy in the fields of allergy, autoimmunity, infectious diseases, and cancer.

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“…Thus, based on these findings, bacteria-based nano strategies for HIFU ablation have focused on bacterial targeting instead of using bacteria-containing NPs ( 79-81 ). Additionally, aptamer-CCFM641-5-functionalized PFH-loaded PLGA NPs ( 82 ) and polyethyleneimine-modified PLGA NPs loaded with sodium bicarbonate ( 83 ) that target Bifidobacterium have been developed to achieve selective delivery of therapeutics into a tumour mass. These two NPs are reported to prolong median survival time of tumour-bearing mice as well as enhance HIFU ablation efficacy.…”

Section: Nano-therapeutics For Hifu-based Cancer Treatmentmentioning

confidence: 99%

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

Zheng¹,

Xia²,

Huang³

et al. 2023

Exp Ther Med

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High-intensity focused ultrasound (HIFU) is a promising and representative non-invasive therapeutic method for treating cancer with a high degree of efficacy. This non-invasive method induces tumour cell necrosis by increasing the local temperature and mechanical pressure. However, the clinical application of HIFU is limited given its low penetration depth and the incidence of off-target side effects. With their promising structural adjustability and targeting ability, nanomedicines have been adopted to improve the ablative efficacy of HIFU in the treatment of cancer. By selectively changing the acoustic environment (tissue structure, density and blood supply) of tumour tissue, these nanomedicines may allow for lower HIFU doses and treatment duration, while additionally achieving a higher degree of efficacy. The use of nanomedicines may also enable cancer theranostics of HIFU, allowing for precise cancer therapeutics. The present review aimed to provide an overview of advances in nanomedicines for HIFU cancer treatment and theranostics, stating their current limitations and future perspectives. Contents 1. Introduction 2. Nano-therapeutics for HIFU-based cancer treatment 3. Nano-based HIFU cancer theranostics 4. Conclusions and future perspectives

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Polyethylenimine (PEI)-modified poly (lactic-co-glycolic) acid (PLGA) nanoparticles conjugated with tumor-homing bacteria facilitate high intensity focused ultrasound-mediated tumor ablation

Cited by 10 publications

References 21 publications

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

PLGA Particles in Immunotherapy

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

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