Polyfunctional Nanosystems on Amphiphilic and Hybrid Platform: Self-Assembly, Mesogenic Properties and Application

Zhil’tsova, E. P.; Ibatullina, M. R.; Mirgorodskaya, A. B.; Gainanova, G. A.; Kuznetsova, Darya A.; Kashapov, Ruslan R.; Zakharova, L. Ya.

doi:10.18083/lcappl.2020.3.5

Cited by 2 publications

(2 citation statements)

References 132 publications

(184 reference statements)

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“…From the viewpoint of biomedical application, a further avenue for research would be to focus on the design of versatile amphiphilic platforms with stimuli-responsive functions and targeted moieties responsible for the construction of surface-active agents with controlled morphological behavior and addressed biological function. In this context, surfactants with the pHdependent group, macrocyclic derivatives, metallosurfactants, and amphiphilic peptides are of special interest [5,24].…”

Section: Discussionmentioning

confidence: 99%

“…An effective way to enhance the therapeutic effect of drugs is via the application of nanocontainers, which solve a variety of serious problems connected with drug toxicity and side effects, low biocompatibility and bioavailability, premature drug degradation upon storage and in biological fluids, overcoming biological barriers, etc. Currently, many different types of drug delivery systems are documented that are classified in terms of the nanocarrier material used, the administration route, the biological target, and the drug loaded [1][2][3][4][5]. In this review, special attention is devoted to amphiphilic nanocarriers, with the role of synthetic surfactants emphasized.…”

Section: Introductionmentioning

confidence: 99%

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Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

et al. 2021

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This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.

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Section: Discussionmentioning

confidence: 99%