2022
DOI: 10.1101/2022.02.16.479923
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Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients

Abstract: Local T cell responses are required for optimal protection of the lungs against airborne pathogens. This localized protection is mediated by various immune cells, including resident memory T cells (TRM). While human lung CD8+ TRM line the epithelium and are enriched for recognition of respiratory viruses, we found CD4+ TRM to exhibit more heterogeneous localization patterns, surrounding airways, forming clusters in the lung parenchyma, and lining the epithelium. This heterogeneity was also reflected functional… Show more

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