Polyfunctional pyrazoles 6.* Convenient method for the synthesis of 1-aryl-1H-pyrazole-3,4-dicarboxylic acids

Братенко, М. К.; Барус, М. М.; Вовк, М. В.

doi:10.1007/s10593-010-0491-4

Cited by 2 publications

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“…Bratenko et al . developed a convenient method for the synthesis of 1‐aryl‐1 H ‐pyrazole‐3,4‐di‐carboxylic acids (50) via alkaline hydrolysis and oxidation of 1‐aryl‐4‐formyl‐1 H ‐pyrazole‐3‐carboxylic esters (49) with hydrogen peroxide in an aqueous medium (Scheme ) .…”

Section: Synthesis and Applications Of Ethyl 4‐formyl‐1‐aryl‐1h‐pyrazmentioning

confidence: 99%

4‐Formyl‐Pyrazole‐3‐Carboxylate: A Useful Aldo‐X Bifunctional Precursor for the Syntheses of Pyrazole‐fused/Substituted Frameworks

Devi

Shankar

Singh

2017

Journal of Heterocyclic Chem

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Pyrazole, a privileged class of heterocyclic compounds, constitute an interesting template for medicinal chemistry and is represented by several commercial drugs like Sildenafil, Zometapin, Celebrex, and Rimonabant. The presence of two functionalities with different reactivity in pyrazole moiety may open new avenues for insertion of diversity in pyrazole frameworks which may be of high medicinal significance. Ethyl 4‐formyl‐1H‐pyrazole‐3‐carboxylate is a potential Aldo‐X bifunctional building block (AXB3) which may be explored for generating complex pyrazole based molecular frameworks by using various organic transformations. The present manuscript is assimilation of literature pertaining to the synthesis and application of ethyl 4‐formyl‐1H‐pyrazole‐3‐carboxylates and similar AXB3 for the development of pyrazole substituted and fused derivatives.

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Section: Synthesis and Applications Of Ethyl 4‐formyl‐1‐aryl‐1h‐pyrazmentioning

confidence: 99%

4‐Formyl‐Pyrazole‐3‐Carboxylate: A Useful Aldo‐X Bifunctional Precursor for the Syntheses of Pyrazole‐fused/Substituted Frameworks

Devi

Shankar

Singh

2017

Journal of Heterocyclic Chem

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ChemInform Abstract: Polyfunctional Pyrazoles. Part 6. Convenient Method for the Synthesis of 1‐Aryl‐1H‐pyrazole‐3,4‐dicarboxylic Acids.

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Polyfunctional pyrazoles 6.* Convenient method for the synthesis of 1-aryl-1H-pyrazole-3,4-dicarboxylic acids

Cited by 2 publications

References 11 publications

4‐Formyl‐Pyrazole‐3‐Carboxylate: A Useful Aldo‐X Bifunctional Precursor for the Syntheses of Pyrazole‐fused/Substituted Frameworks

4‐Formyl‐Pyrazole‐3‐Carboxylate: A Useful Aldo‐X Bifunctional Precursor for the Syntheses of Pyrazole‐fused/Substituted Frameworks

ChemInform Abstract: Polyfunctional Pyrazoles. Part 6. Convenient Method for the Synthesis of 1‐Aryl‐1H‐pyrazole‐3,4‐dicarboxylic Acids.

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