Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

Thoday, J. M.; Thompson, James N.

doi:10.1038/hdy.1984.121

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…We performed similar selection with mutations in rhomboid (rho ve-1 ) and net (net 1 ) genes. Mutations with similar phenotypic consequences are present in low frequencies in natural populations (33) and previous selection experiments with these have produced rapid phenotypic response by artificial selection (24,(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

Chari

Marier

Porter

et al. 2017

Preprint

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Abstract:Populations are constantly exposed to deleterious alleles, most of which are purged via natural selection. However, deleterious fitness effects of alleles can also be suppressed by compensatory adaptation. Compensatory mutations can act directly to reduce deleterious effects of an allele. Alternatively, compensation may also occur by altering other aspects of an organisms' phenotype or performance, without suppressing the phenotypic effects of the deleterious allele. Moreover, the origin of allelic variation contributing to compensatory adaptation remains poorly understood. Compensatory evolution driven by mutations that arise during the selective process are well studied. However less is known about the role standing (cryptic) genetic variation plays in compensatory adaptation. To address these questions, we examined evolutionary trajectories of natural populations of Drosophila melanogaster fixed for mutations that disrupt wing morphology, resulting in deleterious effects on several components of fitness. Lineages subjected only to natural selection, evolved modifications to courtship behavior and several life history traits without compensation in wing morphology. Yet, we observed rapid phenotypic compensation of wing morphology under artificial selection, consistent with segregating variation for compensatory alleles. We show that alleles contributing to compensation of wing morphology have deleterious effects on other fitness components. These results demonstrate the potential for multiple independent avenues for rapid compensatory adaptation from standing genetic variation, which ultimately may reveal novel adaptive trajectories.

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Section: Discussionmentioning

confidence: 99%

Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

Chari

Marier

Porter

et al. 2017

Preprint

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“…The importance of modifiers of mutant expression with respect to phenomena such as evolution of dominance (see Sved and Mayo, 1970), canalization and development (Rendel, 1979;Thompson and Woodruff, 1982) and mimicry (Turner, 1977) has been widely discussed. Nowadays, however, there is very little information about the extent of genetic variation for modifiers of mutant expression in natural populations although some efforts have been addressed to this subject (Alvarez et a!., 1980;Thoday and Thompson, 1984;Thompson and Spivey, 1984).…”

Section: Introductionmentioning

confidence: 99%

Genetic variation in a modifier system affecting the expression of Bare mutant of Drosophila subobscura

Álvarez

Martı́nez

1990

Heredity

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Genetic variation affecting the expression of Bare (Ba), a morphological mutant of Drosophila subobscura that reduces the number of bristles and is located on the 0 chromosome of this species, is reported. Our results show that 0 chromosomes extracted from a natural population (El Pedroso, Santiago de Compostela, Spain) show considerable genetic variation in modifier effect upon Ba expression. The amount of modifier variability is dependent on the chromosomal arrangement (OsT and 03÷4+7), since modifier variation is higher in °ST than in 03÷4+7 chromosomes. Investigations of the genetic architecture of this modifier system on the 0 chromosome carried out using biometrical methods indicate that a relatively small number of genetic "factors" can explain the differences in modifier effect between a wild 0 chromosome of high modifier effect and a marker chromosome of low score. In addition, the modifier effects show a non-uniform distribution along the 0 chromosome and some indication of clustering of modifier "factors" around the major locus (Ba) is also observed.

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Measuring selective effects of modifier gene polymorphisms on the Bare locus of Drosophila subobscura

Álvarez

1996

Heredity

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An attempt to quantify the effects of modifier gene polymorphisms on the operation of natural selection on a major locus has been carried out. The modifier system we have investigated is constituted by a set of polygenic modifier loci affecting the morphological expression of the Bare (Ba) bristle mutant of Drosophila subobscura. Ba is a dominant mutant that is lethal in homozygous condition and both the polygenic modifiers and Ba are located on the 0 chromosome of this species. Experimental populations were founded with Ba! + individuals and two different types of populations were started according to their modifier genetic background: populations with wild 0 chromosomes of either high or low modifier effect (cages H and L, respectively). Fitness estimates (total fitness, viability and fertility) for genotypes of the Ba locus were obtained under the two different modifier backgrounds. In the populations with high modifier background the total fitness of the Ba! + heterozygote was very similar to that of the +/+ homozygote (fitness equal to 1). However, in cages with low modifier background a strong selection against the Ba! + heterozygote was detected (average of total fitnesses over generations was 0.66±0.10), and fertility appears to be the fitness component responsible for this effect (mean fertility was 0.55 0.08). These findings demonstrate that modifier gene polymorphisms affecting the expression of the Ba mutant may be associated with large selective effects on the major locus.

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Polygene polymorphism affecting wing vein formation in a natural population of Drosophila melanogaster

Cited by 3 publications

References 14 publications

Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

Genetic variation in a modifier system affecting the expression of Bare mutant of Drosophila subobscura

Measuring selective effects of modifier gene polymorphisms on the Bare locus of Drosophila subobscura

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