2023
DOI: 10.1182/bloodadvances.2023010562
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Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism

Abstract: Major depessive disorder (MDD), bipolar disorder (BD) and schizophrenia (SCZ) are accompanied by an increased risk of cardiovascular diseases including venous thromboembolism (VTE). Reasons for this are complex, and include obesity, smoking and use of hormone and psychotropic medications. Genetic studies increasingly provide evidence of shared genetic risk of psychiatric and cardiometabolic illness. This study aimed to determine whether genetic predisposition to MDD, BD or SCZ was associated with an increased … Show more

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Cited by 7 publications
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“…The lifetime risk of SCZ is approximately 1%, accompanied by significant morbidity and mortality. Additionally, this condition imposes substantial economic burdens on both families and society [ 2 , 3 , 4 ]. Despite the accessibility of Western medicine for schizophrenia, a significant proportion of patients exhibit a poor response to these treatments [ 5 ].…”
Section: Introductionmentioning
confidence: 99%
“…The lifetime risk of SCZ is approximately 1%, accompanied by significant morbidity and mortality. Additionally, this condition imposes substantial economic burdens on both families and society [ 2 , 3 , 4 ]. Despite the accessibility of Western medicine for schizophrenia, a significant proportion of patients exhibit a poor response to these treatments [ 5 ].…”
Section: Introductionmentioning
confidence: 99%