2017
DOI: 10.15288/jsad.2017.78.442
|View full text |Cite
|
Sign up to set email alerts
|

Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study

Abstract: ABSTRACT. Objective: Alcohol use problems are common during adolescence and can predict serious negative outcomes in adulthood, including substance dependence and psychopathology. The current study examines the notion that alcohol use problems are driven by polygenic influences and that genetic influences may indirectly affect alcohol use problems through multiple pathways of risk, including variations in personality. Method: We used a genome-wide approach to examine associations between genetic risk for alcoh… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

3
28
0

Year Published

2018
2018
2021
2021

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 32 publications
(31 citation statements)
references
References 66 publications
3
28
0
Order By: Relevance
“…To determine whether the mediation models could be explained by other factors, sensitivity analyses were conducted by examining the indirect effects of the phenotypic and polygenic models of ADHD on externalizing trajectories via the effects of adolescent sensation seeking , a key marker of risk for adult substance use and externalizing outcomes and a putative intermediate phenotype (Li et al., ). Controlling for the same covariates, the models were completely consistent with the main findings.…”
Section: Resultsmentioning
confidence: 99%
“…To determine whether the mediation models could be explained by other factors, sensitivity analyses were conducted by examining the indirect effects of the phenotypic and polygenic models of ADHD on externalizing trajectories via the effects of adolescent sensation seeking , a key marker of risk for adult substance use and externalizing outcomes and a putative intermediate phenotype (Li et al., ). Controlling for the same covariates, the models were completely consistent with the main findings.…”
Section: Resultsmentioning
confidence: 99%
“…In young adulthood, genetic influences on alcohol use vary as a function of romantic relationship status and social support networks (Barr et al, 2017). We have extended these studies to include measured polygenetic risk scores, characterizing the mediating pathways by which genetic risk is operating, and the environments that moderate associations of polygenic risk scores with adverse outcomes (Barr et al, 2019;Li et al, 2017;Salvatore et al, 2014;Salvatore et al, 2018;Savage, Salvatore et al, 2018). These studies underscore the important role of multiple environmental contexts in exacerbating or buffering the impact of genetic influences on alcohol use outcomes emerging during early adulthood.…”
Section: Genetic and Environmental Influences On Alcohol Outcomesmentioning
confidence: 99%
“…Substance use outcomes encompass nearly all of the many challenges inherent in studying complex behavioral disorders and outcomes. At the population level, they have a significant genetic component, but are also strongly influenced by the environment, 23,24,34,35 and twin studies provide further evidence that the heritability can vary considerably as a function of the environment [52][53][54][55][56][57][58][59] An environmental exposure is necessary for the development of disorder (access to and ingestion of a substance), making it a rich area for the study of gene-environment interaction (GxE). Substance use disorders are phenotypically heterogeneous, with multiple pathways of risk 60 and manifestations of the disorder.…”
Section: The Potential Of Gene Finding For Psychiatric Outcomesmentioning
confidence: 99%
“…and aggregate polygenic risk scores may impact AUDs by influencing one's subjective response to alcohol, 101 functional differences in brain reward systems 102 and personality traits like impulsivity. 57,58,103 Functional annotation of the genetic and biological processes implicated by GWAS variants 104,105 can also serve to improve our understanding of the many mechanisms leading from genes to complex behaviors.…”
Section: Understanding Mechanismmentioning
confidence: 99%
See 1 more Smart Citation