Polygenic scores of diabetes-related traits in subgroups of type 2 diabetes in India: a cohort study

Yajnik, Chittaranjan S; Wagh, Rucha; Kunte, Pooja; Asplund, Olof; Ahlqvist, Emma; Bhat, Dattatray; Shukla, Sharvari; Prasad, Rashmi B.

doi:10.1016/j.lansea.2023.100182

Cited by 8 publications

(1 citation statement)

References 64 publications

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“…Recent studies that have used data-driven cluster analysis based on six clinical variables to identify specific diabetes subgroups in adult populations with diabetes have also described an insulin-deficient cluster of T2D, termed severe insulin-deficient diabetes (SIDD). 31 – 36 The only study that has used the data-driven cluster analysis in an adult African population was conducted on Ghanaians with adult-onset diabetes. The SIDD cluster was identified in 6.5% of the participants.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic characterization of nonautoimmune diabetes in adult Ugandans with low body mass index

Kibirige,

Sekitoleko,

Lumu

et al. 2024

Therapeutic Advances in Endocrinology

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Background: Type 2 diabetes is common in relatively lean individuals in sub-Saharan Africa. It is unclear whether phenotypic differences exist between underweight and normal-weight African patients with type 2 diabetes. This study compared specific characteristics between underweight (body mass index <18.5 kg/m2) and normal-weight (body mass index of 18.5–24.9 kg/m2) adult Ugandans with new-onset nonautoimmune diabetes. Methods: We collected the demographic, clinical, anthropometric, and metabolic characteristics of 160 participants with nonobese new-onset type 2 diabetes (defined as diabetes diagnosed <3 months, body mass index <25 kg/m2, and absence of islet-cell autoimmunity). These participants were categorized as underweight and normal weight, and their phenotypic characteristics were compared. Results: Of the 160 participants with nonobese new-onset type 2 diabetes, 18 participants (11.3%) were underweight. Compared with those with normal weight, underweight participants presented with less co-existing hypertension (5.6% versus 28.2%, p = 0.04) and lower median visceral fat levels [2 (1–3) versus 6 (4–7), p < 0.001], as assessed by bioimpedance analysis. Pathophysiologically, they presented with a lower median 120-min post-glucose load C-peptide level [0.29 (0.13–0.58) versus 0.82 (0.39–1.50) nmol/l, p = 0.04] and a higher prevalence of insulin deficiency (66.7% versus 31.4%, p = 0.003). Conclusion: This study demonstrates that nonautoimmune diabetes occurs in underweight individuals in sub-Saharan Africa and is characterized by the absence of visceral adiposity, reduced late-phase insulin secretion, and greater insulin deficiency. These findings necessitate further studies to inform how the prevention, identification, and management of diabetes in such individuals can be individualized.

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